BORC5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BORC5_MOUSE
• UniProt AC: Q9D920
• Protein Name: BLOC-1-related complex subunit 5 {ECO:0000305}
• Gene Name: Borcs5 {ECO:0000312|MGI:MGI:1915024}
• Organism: Mus musculus (Mouse).
• Sequence Length: 195
• Subcellular Localization: Lysosome membrane ; Lipid-anchor ; Cytoplasmic side .
• Protein Description: As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Thereby, it may indirectly play a role in cell spreading and motility..
• Protein Sequence: MGSEQSAEAESRPGDLNASVTPSPAKHRAKMDDIVVVAQGSQASRNVSNDPDVIKLQEIPTFQPLLKGLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAFDQNALVKRIKEMDLSVETLFCFMQERQKRYAKYAEQIQKVNEMSAILRRIQMGIDQTVPLMERLNSMLPEAERLEPFSMKPERERH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGSEQSAEA ------CCCHHHHCH		-
19	Phosphorylation	RPGDLNASVTPSPAK CCCCCCCCCCCCHHH		20415495
21	Phosphorylation	GDLNASVTPSPAKHR CCCCCCCCCCHHHHC		28066266
23	Phosphorylation	LNASVTPSPAKHRAK CCCCCCCCHHHHCCC		23384938
30	Ubiquitination	SPAKHRAKMDDIVVV CHHHHCCCCCCEEEE		-
44	Phosphorylation	VAQGSQASRNVSNDP EECCCHHHCCCCCCC		21454597
71	Phosphorylation	PLLKGLLSGQTSPTN HHHHHHHCCCCCCCC		22324799
74	Phosphorylation	KGLLSGQTSPTNAKL HHHHCCCCCCCCHHH		25521595
75	Phosphorylation	GLLSGQTSPTNAKLE HHHCCCCCCCCHHHH		25521595
77	Phosphorylation	LSGQTSPTNAKLEKL HCCCCCCCCHHHHHC		25521595
166	Phosphorylation	IQMGIDQTVPLMERL HHHCCCCHHHHHHHH		24759943

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BORC5_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
2	G	Myristoylation	Myristoylation at Gly-2 mediates attachment to lysosome membranes.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BORC5_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of BORC5_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.