PSD3_MOUSE - dbPTM
PSD3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PSD3_MOUSE
UniProt AC Q2PFD7
Protein Name PH and SEC7 domain-containing protein 3
Gene Name Psd3
Organism Mus musculus (Mouse).
Sequence Length 1037
Subcellular Localization Cell membrane . Cell projection, ruffle membrane . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . In interphase associated with the plasma membrane, in particular with membrane ruffling regions.
Protein Description Guanine nucleotide exchange factor for ARF6..
Protein Sequence MEGRNAAAEPFVWVNSASAHSQSVAKAKYEFLFGKSEEKTPDSSDHGGSTLLPPTVTNEFPEYGTMEEGGEGLRASLDFDAKSPPCRLPGQQAVHLLAGQDSILNSVTEGPNDAPQCHPQEQSLQPIDSLISALKATEARIASGTFQATKVLDKDANFSVYQVDKELSTASHKPQRAHRTFPVGPGKSPDIPLSAEVPTEENLSLHIQEDLSALLPEEAQAHRSQITNYRRQGPLRVPESACPVSSSSAGSHNPVDRVGALREQRSDLGREHPRGYDRGGSMGRQGRIKHVEFQGVEILWTGEEAESRHPPERTASPVSKEFAKRPSHSSPACGVCSTSTHLTGDVWDETCKAPSERPGTSAGTLSPMPLGESGEDDVFLRESKEHLEENFAIQGDKERILDQEEHLRGDDDILGPGYTEDSTDVYSSQFETILDNTSLYYSAESLETLYSEPDSYFSFEMPLTPMIQQRIKEGGQFLERTSVGGQHDVLSVSADGGIVMGYSAGITNGLHDSANSVYTRGPQEIAFWGSRDRCFAEGKTTGVDAGSEMGSTDILEKETTESLSNGTNSNVEAAKRLAKRLYHLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFLKAFSLVGETQERERVLIHFSNRYFSCNPDTITSKDGVHCLTCAMMLLNTDLHGHVNIGKKMTCQEFITNLQGVNEGGDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSEGTDEKANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKSLSDEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEIYVSVLKEGGKELLTTDGNEPVGLKKSHSSPSLNPDASPVTAKVKRNVSERKDHRPETPGIKQKVT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
29PhosphorylationQSVAKAKYEFLFGKS
HHHHHHHHHHHHCCC		19.4429514104
36PhosphorylationYEFLFGKSEEKTPDS
HHHHHCCCCCCCCCC		51.9029514104
43PhosphorylationSEEKTPDSSDHGGST
CCCCCCCCCCCCCCC		38.5824719451
76PhosphorylationGGEGLRASLDFDAKS
CCCCCEEEECCCCCC		23.2625521595
83PhosphorylationSLDFDAKSPPCRLPG
EECCCCCCCCCCCCC		35.4819060867
229PhosphorylationHRSQITNYRRQGPLR
HHHHCCCCHHCCCCC		9.8729514104
240PhosphorylationGPLRVPESACPVSSS
CCCCCCHHHCCCCCC		29.1515345747
245O-linked_GlycosylationPESACPVSSSSAGSH
CHHHCCCCCCCCCCC		15.0522517741
248PhosphorylationACPVSSSSAGSHNPV
HCCCCCCCCCCCCCC		38.3015345747
278MethylationEHPRGYDRGGSMGRQ
CCCCCCCCCCCCCCC		42.7858859187
283PhosphorylationYDRGGSMGRQGRIKH
CCCCCCCCCCCCEEE		22.0624719451
314PhosphorylationSRHPPERTASPVSKE
HCCCCCCCCCCCCHH		29.8023527152
316PhosphorylationHPPERTASPVSKEFA
CCCCCCCCCCCHHHH		25.8123527152
320AcetylationRTASPVSKEFAKRPS
CCCCCCCHHHHCCCC		58.0219852619
360PhosphorylationAPSERPGTSAGTLSP
CCCCCCCCCCCCCCC		20.3425338131
361PhosphorylationPSERPGTSAGTLSPM
CCCCCCCCCCCCCCC		30.5325338131
366PhosphorylationGTSAGTLSPMPLGES
CCCCCCCCCCCCCCC		20.9923984901
373PhosphorylationSPMPLGESGEDDVFL
CCCCCCCCCCCCCEE		45.7626643407
383PhosphorylationDDVFLRESKEHLEEN
CCCEECCCHHHHHHH		36.5930352176
551PhosphorylationDAGSEMGSTDILEKE
CCCCCCCCCCHHHHH		22.9229514104
590PhosphorylationHLDRFKRSDVAKHLG
CHHHHCHHHHHHHHC		36.7125338131
604UbiquitinationGKNNEFSKLVAEEYL
CCCCHHHHHHHHHHH		52.91-
717PhosphorylationKDLLKALYNSIKNEK
HHHHHHHHHHHHCCC		16.2429899451
719PhosphorylationLLKALYNSIKNEKLE
HHHHHHHHHHCCCCC		22.7629899451
737PhosphorylationDDEEKKKSPSEGTDE
CHHHHHCCCCCCCCC		42.4018388127
742PhosphorylationKKSPSEGTDEKANGT
HCCCCCCCCCCCCCC		36.6129899451
753PhosphorylationANGTHPKTISRIGST
CCCCCCCCCHHCCCC		28.7429899451
755PhosphorylationGTHPKTISRIGSTTN
CCCCCCCHHCCCCCC		24.0729899451
759PhosphorylationKTISRIGSTTNPFLD
CCCHHCCCCCCCCCC		29.6825521595
760PhosphorylationTISRIGSTTNPFLDI
CCHHCCCCCCCCCCC		25.9425521595
761PhosphorylationISRIGSTTNPFLDIP
CHHCCCCCCCCCCCC		42.4625521595
776PhosphorylationHDPNAAVYKSGFLAR
CCCCCHHHHCCHHHH		8.4924925903
794PhosphorylationADMDGKKTPRGKRGW
ECCCCCCCCCCCCCH		23.0025338131
825PhosphorylationDEYKPEKSLSDEDLK
CCCCCCCCCCHHHHH		31.2925521595
827PhosphorylationYKPEKSLSDEDLKNA
CCCCCCCCHHHHHHH		46.1520415495
844UbiquitinationVHHALASKATDYEKK
HHHHHHHCCCCCCCC		50.10-
900PhosphorylationPFPAAIGSQKKFSRP
CCCCCCCCCCCCCCC		32.4829899451
905PhosphorylationIGSQKKFSRPLLPAT
CCCCCCCCCCCCCCC		41.7029899451
917PhosphorylationPATTTKLSQEEQLKS
CCCCCCCCHHHHHHH		36.7829899451
941PhosphorylationTELAEHRSYPPDKKV
HHHHHHCCCCCCCCC		43.8529514104
942PhosphorylationELAEHRSYPPDKKVK
HHHHHCCCCCCCCCC		20.8129514104
957UbiquitinationAKDVDEYKLKDHYLE
CCCCCHHHCHHHEEE		47.19-
968PhosphorylationHYLEFEKTRYEIYVS
HEEEEECCEEEEEEE		31.1424719451
982UbiquitinationSVLKEGGKELLTTDG
EEEECCCEEEEECCC		56.92-
986PhosphorylationEGGKELLTTDGNEPV
CCCEEEEECCCCCCC		35.1529899451
987PhosphorylationGGKELLTTDGNEPVG
CCEEEEECCCCCCCC		41.7129899451
996UbiquitinationGNEPVGLKKSHSSPS
CCCCCCCCCCCCCCC		46.42-
998PhosphorylationEPVGLKKSHSSPSLN
CCCCCCCCCCCCCCC		27.3225521595
1000PhosphorylationVGLKKSHSSPSLNPD
CCCCCCCCCCCCCCC		51.5425521595
1001PhosphorylationGLKKSHSSPSLNPDA
CCCCCCCCCCCCCCC		17.0625521595
1003PhosphorylationKKSHSSPSLNPDASP
CCCCCCCCCCCCCCC		42.6025521595
1009PhosphorylationPSLNPDASPVTAKVK
CCCCCCCCCCHHHHH		27.5525521595
1012PhosphorylationNPDASPVTAKVKRNV
CCCCCCCHHHHHCCH		24.9324925903
1020PhosphorylationAKVKRNVSERKDHRP
HHHHCCHHHCCCCCC		34.9223737553
1029PhosphorylationRKDHRPETPGIKQKV
CCCCCCCCCCCCCCC		29.5125521595
1037PhosphorylationPGIKQKVT-------
CCCCCCCC-------		39.6721454597
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PSD3_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PSD3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PSD3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PSD3_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PSD3_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1009, AND MASSSPECTROMETRY.
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-759, AND MASSSPECTROMETRY.
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations.";
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.;
Mol. Cell. Proteomics 5:914-922(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1009, AND MASSSPECTROMETRY.
"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1000; SER-1001 ANDSER-1009, AND MASS SPECTROMETRY.

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