MTMR1_MOUSE - dbPTM
MTMR1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MTMR1_MOUSE
UniProt AC Q9Z2C4
Protein Name Myotubularin-related protein 1
Gene Name Mtmr1
Organism Mus musculus (Mouse).
Sequence Length 669
Subcellular Localization Cell membrane
Peripheral membrane protein
Cytoplasmic side . Cytoplasm .
Protein Description Lipid phosphatase that has high specificity for phosphatidylinositol 3-phosphate and has no activity with phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. [PubMed: 12217958). Activity with phosphatidylinositol (3]
Protein Sequence MDRPVAAAAAASAASCEGAGGPGPGPGASWRPSRVAGGASASSRHPSIETLDSPTGSHVEWCKQLIAATISSQISGSVTSENVSRDYKALRDGNKLAQMEEAPLFPGESIKAIVKDVIYICPFMGAVSGTLTVTDFKMYFKNVERDPHFVLDVPLGVISRVEKIGAQSHGDNSCGIEIVCKDMRNLRLAYKQEEQRKLGIFENLNKHAFPLSNGQVLFAFNYKEKFPVNGWKVYDPVSEYKRQGLPNESWKISKINSNYEFCDTYPAIIVVPTSVKDDDLSKVAAFRAKGRVPVLSWIHPESQATITRCSQPLVGPNDKRCKEDEKYLQTIMDANAQSHKLTIFDARQNSVADTNKAKGGGYENESAYPNAELIFLEIHNIHVMRESLRKLKEIVYPSIDESHWLSNVDGTHWLEYIRVLLAGAVRIADKIESGKTSVVIHCSDGWDRTSQLTSLAMLMLDSYYRTIKGFEALIEKEWISFGHRFALRVGHGDDNHADADRSPIFLQFIDCVWQMTRQFPSAFEFNELFLITILDHLYSCLFGTFLCNCEQQRIKEDVYTNTISLWSYINSQLDEFSNPFFVNYENHVLYPVASMSHLELWVNYYVRWNPRMRPQMPIHQNLKELLAIKAELQKRVEDLQREMATRTISSSSERGSSPTHSATPVHTSV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MDRPVAAA
-------CCHHHHHH		9.95-
29PhosphorylationPGPGPGASWRPSRVA
CCCCCCCCCCHHHCC		29.5417242355
40PhosphorylationSRVAGGASASSRHPS
HHCCCCCCCCCCCCC		31.7726745281
42PhosphorylationVAGGASASSRHPSIE
CCCCCCCCCCCCCCC		25.9626745281
43PhosphorylationAGGASASSRHPSIET
CCCCCCCCCCCCCCC		34.0326745281
47PhosphorylationSASSRHPSIETLDSP
CCCCCCCCCCCCCCC		27.2525521595
50PhosphorylationSRHPSIETLDSPTGS
CCCCCCCCCCCCCCH		33.9124925903
53PhosphorylationPSIETLDSPTGSHVE
CCCCCCCCCCCHHHH		27.7224925903
55PhosphorylationIETLDSPTGSHVEWC
CCCCCCCCCHHHHHH		56.0924925903
57PhosphorylationTLDSPTGSHVEWCKQ
CCCCCCCHHHHHHHH		27.1722324799
143UbiquitinationFKMYFKNVERDPHFV
HHHHHCCCCCCCCEE		7.0427667366
225UbiquitinationFAFNYKEKFPVNGWK
EEEECCCCCCCCCEE		51.3022790023
241UbiquitinationYDPVSEYKRQGLPNE
ECCHHHHHHCCCCCC		33.9127667366
249UbiquitinationRQGLPNESWKISKIN
HCCCCCCCCEEEECC		40.0727667366
258UbiquitinationKISKINSNYEFCDTY
EEEECCCCCCCCCCC		35.5527667366
266UbiquitinationYEFCDTYPAIIVVPT
CCCCCCCCEEEEEEC		21.0527667366
275UbiquitinationIIVVPTSVKDDDLSK
EEEEECCCCCCCHHH		9.6727667366
305PhosphorylationIHPESQATITRCSQP
ECHHHCCCEEECCCC		18.4227180971
307PhosphorylationPESQATITRCSQPLV
HHHCCCEEECCCCCC		22.6727180971
443PhosphorylationTSVVIHCSDGWDRTS
EEEEEECCCCCCHHH		25.6228059163
449PhosphorylationCSDGWDRTSQLTSLA
CCCCCCHHHHHHHHH		20.5328059163
647PhosphorylationQREMATRTISSSSER
HHHHHHHHCCCCCCC		22.3623984901
649PhosphorylationEMATRTISSSSERGS
HHHHHHCCCCCCCCC		24.4526160508
650PhosphorylationMATRTISSSSERGSS
HHHHHCCCCCCCCCC		33.7526160508
651PhosphorylationATRTISSSSERGSSP
HHHHCCCCCCCCCCC		29.4526160508
652PhosphorylationTRTISSSSERGSSPT
HHHCCCCCCCCCCCC		33.0126160508
656PhosphorylationSSSSERGSSPTHSAT
CCCCCCCCCCCCCCC		39.0924925903
657PhosphorylationSSSERGSSPTHSATP
CCCCCCCCCCCCCCC		36.3224925903
659PhosphorylationSERGSSPTHSATPVH
CCCCCCCCCCCCCCC		30.3424925903
661PhosphorylationRGSSPTHSATPVHTS
CCCCCCCCCCCCCCC		35.9924925903
663PhosphorylationSSPTHSATPVHTSV-
CCCCCCCCCCCCCC-		28.9424925903
667PhosphorylationHSATPVHTSV-----
CCCCCCCCCC-----		31.2728833060
667O-linked_GlycosylationHSATPVHTSV-----
CCCCCCCCCC-----		31.2755472697
668PhosphorylationSATPVHTSV------
CCCCCCCCC------		15.7928833060
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MTMR1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MTMR1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MTMR1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MTMR1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MTMR1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47, AND MASSSPECTROMETRY.

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