dbPTM

RFIP5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RFIP5_MOUSE
UniProt AC	Q8R361
Protein Name	Rab11 family-interacting protein 5
Gene Name	Rab11fip5
Organism	Mus musculus (Mouse).
Sequence Length	645
Subcellular Localization	Cytoplasm. Recycling endosome membrane Peripheral membrane protein . Early endosome membrane Peripheral membrane protein . Golgi apparatus membrane Peripheral membrane protein . Cytoplasmic vesicle, secretory vesicle membrane Peripheral membrane p
Protein Description	Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis..
Protein Sequence	MALVRDPEPAAGSSRWLPTHVQVTVLRASGLRGKSSGAGSTSDAYTVIQVGREKYSTSVVEKTQGCPEWCEECSFELPPGALDGLLRAQEADAGPAPWASGPNAACELVLTTMHRSLIGVDKFLGRATVALDEVFRAGRAQHTQWYRLHSKPGKKEKERGEIQVTIQFTRNNLSASMFDLSMKDKPRSPFSKLKDRVKGKKKYDLESASAILPSSALEDPELGSLGKMGKAKGFFLRNKLRKSSLTQSNTSLGSDSTLSSTSGSLVYQGPGAELLTRSPSHSSWLSTEGGRDSIQSPKLLTHKRTYSDEASQLRAAPPRALLELQGHLDGASRSSLCVNGSHVYNEEPQPPLRHRSSISGPFPPSSSLHSVPPRSSEEGSRSSDDSWGRGSHGTSSSEAVPGQEELSKQAKGASCSGEEEGARLPEGKPVQVATPMVASSEAVAAEKDRKPRMGLFHHHHHQGLSRSEQGRRGSVGEKGSPSLGASPHHSSTGEEKAKSSWFGLRESKEPTQKPSPHPVKPLTAAPVEASPDRKQPRTSLSTALSSGLERLKTVTSGGIQSVLPASQLGSSVDTKRPKDSAVLDQSAKYYHLTHDELIGLLLQRERELSQRDEHVQELESYIDRLLVRIMETSPTLLQISPGPPK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
116	Phosphorylation	VLTTMHRSLIGVDKF HHHHHHHHHHCHHHH	15.06	27180971
174	Phosphorylation	QFTRNNLSASMFDLS EEECCCCCHHHHEEC	22.03	25619855
176	Phosphorylation	TRNNLSASMFDLSMK ECCCCCHHHHEECCC	19.33	25521595
181	Phosphorylation	SASMFDLSMKDKPRS CHHHHEECCCCCCCC	26.15	25619855
188	Phosphorylation	SMKDKPRSPFSKLKD CCCCCCCCCCHHHHH	38.53	26824392
191	Phosphorylation	DKPRSPFSKLKDRVK CCCCCCCHHHHHHHC	40.23	22324799
203	Phosphorylation	RVKGKKKYDLESASA HHCCCCCCCHHHHHC	34.34	25619855
207	Phosphorylation	KKKYDLESASAILPS CCCCCHHHHHCCCCH	34.52	26824392
209	Phosphorylation	KYDLESASAILPSSA CCCHHHHHCCCCHHH	25.73	25521595
214	Phosphorylation	SASAILPSSALEDPE HHHCCCCHHHHCCCC	25.46	25619855
215	Phosphorylation	ASAILPSSALEDPEL HHCCCCHHHHCCCCC	34.63	25619855
224	Phosphorylation	LEDPELGSLGKMGKA HCCCCCCCCCCHHHH	46.72	25619855
243	Phosphorylation	LRNKLRKSSLTQSNT HHHHHHHHCCCCCCC	24.93	25619855
244	Phosphorylation	RNKLRKSSLTQSNTS HHHHHHHCCCCCCCC	38.17	25619855
246	Phosphorylation	KLRKSSLTQSNTSLG HHHHHCCCCCCCCCC	31.72	25619855
248	Phosphorylation	RKSSLTQSNTSLGSD HHHCCCCCCCCCCCC	36.52	25619855
250	Phosphorylation	SSLTQSNTSLGSDST HCCCCCCCCCCCCCC	30.49	25619855
251	Phosphorylation	SLTQSNTSLGSDSTL CCCCCCCCCCCCCCC	34.68	25619855
254	Phosphorylation	QSNTSLGSDSTLSST CCCCCCCCCCCCCCC	33.41	25619855
256	Phosphorylation	NTSLGSDSTLSSTSG CCCCCCCCCCCCCCC	32.71	25619855
257	Phosphorylation	TSLGSDSTLSSTSGS CCCCCCCCCCCCCCC	35.33	25619855
259	Phosphorylation	LGSDSTLSSTSGSLV CCCCCCCCCCCCCEE	31.49	25619855
260	Phosphorylation	GSDSTLSSTSGSLVY CCCCCCCCCCCCEEE	29.70	25619855
261	Phosphorylation	SDSTLSSTSGSLVYQ CCCCCCCCCCCEEEE	33.46	25619855
262	Phosphorylation	DSTLSSTSGSLVYQG CCCCCCCCCCEEEEC	28.47	25619855
264	Phosphorylation	TLSSTSGSLVYQGPG CCCCCCCCEEEECCC	17.90	25619855
267	Phosphorylation	STSGSLVYQGPGAEL CCCCCEEEECCCCEE	17.04	25619855
278	Phosphorylation	GAELLTRSPSHSSWL CCEEEECCCCCCCCC	26.06	26824392
280	Phosphorylation	ELLTRSPSHSSWLST EEEECCCCCCCCCCC	36.93	26824392
282	Phosphorylation	LTRSPSHSSWLSTEG EECCCCCCCCCCCCC	27.78	27742792
283	Phosphorylation	TRSPSHSSWLSTEGG ECCCCCCCCCCCCCC	26.98	21082442
286	Phosphorylation	PSHSSWLSTEGGRDS CCCCCCCCCCCCCCC	20.39	25619855
287	Phosphorylation	SHSSWLSTEGGRDSI CCCCCCCCCCCCCCC	36.16	25619855
293	Phosphorylation	STEGGRDSIQSPKLL CCCCCCCCCCCCHHH	22.59	26643407
296	Phosphorylation	GGRDSIQSPKLLTHK CCCCCCCCCHHHCCC	23.49	27087446
301	Phosphorylation	IQSPKLLTHKRTYSD CCCCHHHCCCCCCCH	35.47	29514104
305	Phosphorylation	KLLTHKRTYSDEASQ HHHCCCCCCCHHHHH	31.98	25521595
306	Phosphorylation	LLTHKRTYSDEASQL HHCCCCCCCHHHHHH	20.39	23527152
307	Phosphorylation	LTHKRTYSDEASQLR HCCCCCCCHHHHHHH	28.50	18388127
311	Phosphorylation	RTYSDEASQLRAAPP CCCCHHHHHHHCCCH	27.92	25619855
332	Phosphorylation	QGHLDGASRSSLCVN CCCCCCCCCCCEEEC	37.92	26824392
334	Phosphorylation	HLDGASRSSLCVNGS CCCCCCCCCEEECCC	25.76	21082442
356	Phosphorylation	QPPLRHRSSISGPFP CCCCCCCCCCCCCCC	26.37	25619855
357	Phosphorylation	PPLRHRSSISGPFPP CCCCCCCCCCCCCCC	22.26	25619855
359	Phosphorylation	LRHRSSISGPFPPSS CCCCCCCCCCCCCCH	42.22	25619855
367	Phosphorylation	GPFPPSSSLHSVPPR CCCCCCHHCCCCCCC	34.14	-
375	Phosphorylation	LHSVPPRSSEEGSRS CCCCCCCCCCCCCCC	48.12	24719451
376	Phosphorylation	HSVPPRSSEEGSRSS CCCCCCCCCCCCCCC	40.73	24719451
380	Phosphorylation	PRSSEEGSRSSDDSW CCCCCCCCCCCCCCC	32.06	29899451
382	Phosphorylation	SSEEGSRSSDDSWGR CCCCCCCCCCCCCCC	39.55	29899451
383	Phosphorylation	SEEGSRSSDDSWGRG CCCCCCCCCCCCCCC	44.31	25338131
386	Phosphorylation	GSRSSDDSWGRGSHG CCCCCCCCCCCCCCC	36.10	25338131
391	Phosphorylation	DDSWGRGSHGTSSSE CCCCCCCCCCCCCCC	19.86	29899451
394	Phosphorylation	WGRGSHGTSSSEAVP CCCCCCCCCCCCCCC	21.73	24719451
395	Phosphorylation	GRGSHGTSSSEAVPG CCCCCCCCCCCCCCC	36.14	25338131
396	Phosphorylation	RGSHGTSSSEAVPGQ CCCCCCCCCCCCCCH	31.84	25338131
397	Phosphorylation	GSHGTSSSEAVPGQE CCCCCCCCCCCCCHH	29.37	30635358
407	Phosphorylation	VPGQEELSKQAKGAS CCCHHHHHHHHCCCC	26.46	30635358
416	Phosphorylation	QAKGASCSGEEEGAR HHCCCCCCCCHHCCC	46.90	29514104
474	Phosphorylation	SEQGRRGSVGEKGSP CCCCCCCCCCCCCCC	25.74	26824392
480	Phosphorylation	GSVGEKGSPSLGASP CCCCCCCCCCCCCCC	23.53	26824392
482	Phosphorylation	VGEKGSPSLGASPHH CCCCCCCCCCCCCCC	40.92	26824392
486	Phosphorylation	GSPSLGASPHHSSTG CCCCCCCCCCCCCCC	23.98	22324799
490	Phosphorylation	LGASPHHSSTGEEKA CCCCCCCCCCCCHHH	26.93	26160508
491	Phosphorylation	GASPHHSSTGEEKAK CCCCCCCCCCCHHHH	35.75	18846507
492	Phosphorylation	ASPHHSSTGEEKAKS CCCCCCCCCCHHHHH	52.18	29899451
523	Phosphorylation	PHPVKPLTAAPVEAS CCCCCCCCCCCCCCC	29.33	29899451
530	Phosphorylation	TAAPVEASPDRKQPR CCCCCCCCCCCCCCC	17.52	26824392
538	Phosphorylation	PDRKQPRTSLSTALS CCCCCCCHHHHHHHH	40.48	27742792
539	Phosphorylation	DRKQPRTSLSTALSS CCCCCCHHHHHHHHH	22.92	28725479
541	Phosphorylation	KQPRTSLSTALSSGL CCCCHHHHHHHHHHH	16.05	26160508
542	Phosphorylation	QPRTSLSTALSSGLE CCCHHHHHHHHHHHH	36.59	18779572
545	Phosphorylation	TSLSTALSSGLERLK HHHHHHHHHHHHHHC	21.64	26824392
546	Phosphorylation	SLSTALSSGLERLKT HHHHHHHHHHHHHCE	48.52	18779572
553	Phosphorylation	SGLERLKTVTSGGIQ HHHHHHCEECCCCHH	33.34	30635358
555	Phosphorylation	LERLKTVTSGGIQSV HHHHCEECCCCHHEE	27.21	30635358
556	Phosphorylation	ERLKTVTSGGIQSVL HHHCEECCCCHHEEE	30.59	30635358
561	Phosphorylation	VTSGGIQSVLPASQL ECCCCHHEEEEHHHC	24.57	30635358
575	Ubiquitination	LGSSVDTKRPKDSAV CCCCCCCCCCCCCHH	63.34	-
578	Ubiquitination	SVDTKRPKDSAVLDQ CCCCCCCCCCHHHHC	69.24	-
626	Phosphorylation	ESYIDRLLVRIMETS HHHHHHHHHHHHHHC	2.24	24719451
633	Phosphorylation	LVRIMETSPTLLQIS HHHHHHHCCCEEECC	11.55	25777480
635	Phosphorylation	RIMETSPTLLQISPG HHHHHCCCEEECCCC	39.61	25777480
640	Phosphorylation	SPTLLQISPGPPK-- CCCEEECCCCCCC--	15.73	27087446
693	Phosphorylation	------------------------------------------------------- -------------------------------------------------------		24719451
886	Phosphorylation	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		24719451
890	Phosphorylation	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		24719451
1212	Phosphorylation	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		24719451
1218	Phosphorylation	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		24719451
1229	Phosphorylation	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		24719451
1308	Phosphorylation	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		24719451
1313	Phosphorylation	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
188	S	Phosphorylation	Kinase	ERK-SUBFAMILY	-	GPS
307	S	Phosphorylation	Kinase	STK38	Q91VJ4	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
357	S	Phosphorylation		19335615
Phosphorylation at Ser-357 is PKA-dependent.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RFIP5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SNAG_MOUSE	Napg	physical	11278501

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RFIP5_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307, AND MASSSPECTROMETRY.	19131326 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Proteomic analysis of in vivo phosphorylated synaptic proteins."; Collins M.O., Yu L., Coba M.P., Husi H., Campuzano I.,Blackstock W.P., Choudhary J.S., Grant S.G.; J. Biol. Chem. 280:5972-5982(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307, AND MASSSPECTROMETRY.	15572359 [Abstract]
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-306, AND MASSSPECTROMETRY.	17114649 [Abstract]

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