C1QA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: C1QA_MOUSE
• UniProt AC: P98086
• Protein Name: Complement C1q subcomponent subunit A
• Gene Name: C1qa
• Organism: Mus musculus (Mouse).
• Sequence Length: 245
• Subcellular Localization: Secreted.
• Protein Description: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes..
• Protein Sequence: METSQGWLVACVLTMTLVWTVAEDVCRAPNGKDGAPGNPGRPGRPGLKGERGEPGAAGIRTGIRGFKGDPGESGPPGKPGNVGLPGPSGPLGDSGPQGLKGVKGNPGNIRDQPRPAFSAIRQNPMTLGNVVIFDKVLTNQESPYQNHTGRFICAVPGFYYFNFQVISKWDLCLFIKSSSGGQPRDSLSFSNTNNKGLFQVLAGGTVLQLRRGDEVWIEKDPAKGRIYQGTEADSIFSGFLIFPSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	LTMTLVWTVAEDVCR HHHHHHHHHHHHHHC	11.45	20139300
39	Hydroxylation	KDGAPGNPGRPGRPG CCCCCCCCCCCCCCC	46.19	-
45	Hydroxylation	NPGRPGRPGLKGERG CCCCCCCCCCCCCCC	59.38	-
48	Hydroxylation	RPGRPGLKGERGEPG CCCCCCCCCCCCCCC	65.72	-
48	O-linked_Glycosylation	RPGRPGLKGERGEPG CCCCCCCCCCCCCCC	65.72	-
54	Hydroxylation	LKGERGEPGAAGIRT CCCCCCCCCCCCHHC	40.31	-
67	Hydroxylation	RTGIRGFKGDPGESG HCCCCCCCCCCCCCC	66.29	-
67	O-linked_Glycosylation	RTGIRGFKGDPGESG HCCCCCCCCCCCCCC	66.29	-
79	Hydroxylation	ESGPPGKPGNVGLPG CCCCCCCCCCCCCCC	45.57	-
85	Hydroxylation	KPGNVGLPGPSGPLG CCCCCCCCCCCCCCC	46.88	-
100	Hydroxylation	DSGPQGLKGVKGNPG CCCCCCCCCCCCCCC	69.36	-
100	O-linked_Glycosylation	DSGPQGLKGVKGNPG CCCCCCCCCCCCCCC	69.36	-
146	N-linked_Glycosylation	NQESPYQNHTGRFIC CCCCCCCCCCCCEEE	28.92	16944957

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of C1QA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of C1QA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of C1QA_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of C1QA_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Proteome-wide characterization of N-glycosylation events by diagonalchromatography.";
Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J.,Gevaert K.;
J. Proteome Res. 5:2438-2447(2006).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-146, AND MASSSPECTROMETRY.
PubMed: 16944957