| UniProt ID | AT2B1_MOUSE | |
|---|---|---|
| UniProt AC | G5E829 | |
| Protein Name | Plasma membrane calcium-transporting ATPase 1 {ECO:0000303|PubMed:12209837} | |
| Gene Name | Atp2b1 {ECO:0000312|MGI:MGI:104653} | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 1220 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . Cell junction, synapse . Colocalizes with SV2A in photoreceptor synaptic terminals. |
|
| Protein Description | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Involved in bone homeostasis. Has a role in osteoclastogenesis where it regulates RANKL-induced calcium oscillation, a key step in the differentiation process. Also promotes survival of mature osteoclasts, probably by preventing toxic accumulation of intracellular calcium.. | |
| Protein Sequence | MGDMANNSVAYSGVKNSLKEANHDGDFGITLTELRALMELRSTDALRKIQESYGDVYGICTKLKTSPNEGLSGNPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEVSVGEEEGEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDEKKKEKKNKKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGDEKDKKKANLPKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYKKVPEPEAIPPNILSYLVTGISVNCAYTSKILPPEKEGGLPRHVGNKTECALLGFLLDLKRDYQDVRNEIPEEALYKVYTFNSVRKSMSTVLKNSDGSFRIFSKGASEIILKKCFKILSANGEAKVFRPRDRDDIVKTVIEPMASEGLRTICLAFRDFPAGEPEPEWDNENDVVTGLTCIAVVGIEDPVRPEVPEAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPLHAPPSEHYTIVFNTFVLMQLFNEINARKIHGERNVFEGIFNNAIFCTIVLGTFVVQIIIVQFGGKPFSCSELSIEQWLWSIFLGMGTLLWGQLISTIPTSRLKFLKEAGHGTQKEEIPEEELAEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVNAFRSSLYEGLEKPESRSSIHNFMTHPEFRIEDSEPHIPLIDDTDAEDDAPTKRNSSPPPSPNKNNNAVDSGIHLTIEMNKSATSSSPGSPLHSLETSL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MGDMANNSV ------CCCCCCCCH | - | ||
| 8 | Phosphorylation | MGDMANNSVAYSGVK CCCCCCCCHHHHCHH | 20415495 | ||
| 11 | Phosphorylation | MANNSVAYSGVKNSL CCCCCHHHHCHHHHH | 26643407 | ||
| 12 | Phosphorylation | ANNSVAYSGVKNSLK CCCCHHHHCHHHHHH | 26824392 | ||
| 17 | Phosphorylation | AYSGVKNSLKEANHD HHHCHHHHHHHCCCC | 26824392 | ||
| 19 | Ubiquitination | SGVKNSLKEANHDGD HCHHHHHHHCCCCCC | 22790023 | ||
| 30 | Phosphorylation | HDGDFGITLTELRAL CCCCCCEEHHHHHHH | 29899451 | ||
| 32 | Phosphorylation | GDFGITLTELRALME CCCCEEHHHHHHHHH | 25159016 | ||
| 42 | Phosphorylation | RALMELRSTDALRKI HHHHHHHCHHHHHHH | 29899451 | ||
| 48 | Ubiquitination | RSTDALRKIQESYGD HCHHHHHHHHHHHCH | 22790023 | ||
| 52 | Phosphorylation | ALRKIQESYGDVYGI HHHHHHHHHCHHHHH | 29899451 | ||
| 62 | Ubiquitination | DVYGICTKLKTSPNE HHHHHEEECCCCCCC | 22790023 | ||
| 64 | Ubiquitination | YGICTKLKTSPNEGL HHHEEECCCCCCCCC | 22790023 | ||
| 72 | Phosphorylation | TSPNEGLSGNPADLE CCCCCCCCCCHHHHH | - | ||
| 87 | Ubiquitination | RREAVFGKNFIPPKK HHHHHHCCCCCCCCC | 27667366 | ||
| 93 | Ubiquitination | GKNFIPPKKPKTFLQ CCCCCCCCCCHHHHH | 27667366 | ||
| 94 | Ubiquitination | KNFIPPKKPKTFLQL CCCCCCCCCHHHHHH | 27667366 | ||
| 193 | Ubiquitination | SRIEQEQKFTVIRGG HHHHHHCCEEEEECC | 22790023 | ||
| 220 | Phosphorylation | GDIAQVKYGDLLPAD CCCEECCCCCEECCC | 29899451 | ||
| 242 | Phosphorylation | DLKIDESSLTGESDH CEEECHHHCCCCCHH | 27841257 | ||
| 247 | Phosphorylation | ESSLTGESDHVKKSL HHHCCCCCHHHHHHC | 29899451 | ||
| 251 | Ubiquitination | TGESDHVKKSLDKDP CCCCHHHHHHCCCCC | 22790023 | ||
| 256 | Ubiquitination | HVKKSLDKDPLLLSG HHHHHCCCCCEEEEC | 22790023 | ||
| 264 | Phosphorylation | DPLLLSGTHVMEGSG CCEEEECCEEEECCC | - | ||
| 270 | Phosphorylation | GTHVMEGSGRMVVTA CCEEEECCCCEEEEE | - | ||
| 284 | Phosphorylation | AVGVNSQTGIIFTLL EEEECCCCCEEEEEE | 28059163 | ||
| 312 | Ubiquitination | KKEKKNKKQDGAIEN HHHHHHHHHHCHHHC | 27667366 | ||
| 324 | Ubiquitination | IENRNKAKAQDGAAM HHCHHHHHHCCCCCC | 22790023 | ||
| 337 | Ubiquitination | AMEMQPLKSEEGGDG CCCCCCCCCCCCCCC | 27667366 | ||
| 338 | Phosphorylation | MEMQPLKSEEGGDGD CCCCCCCCCCCCCCC | 19144319 | ||
| 452 | Ubiquitination | YSVKKMMKDNNLVRH HHHHHHHCCCCHHHH | 27667366 | ||
| 512 | Phosphorylation | AIPPNILSYLVTGIS CCCCCHHHHHHHCEE | 29899451 | ||
| 533 | Ubiquitination | SKILPPEKEGGLPRH CCCCCCHHCCCCCCC | 22790023 | ||
| 574 | Ubiquitination | IPEEALYKVYTFNSV CCHHHHHHHHCHHHH | - | ||
| 580 | Phosphorylation | YKVYTFNSVRKSMST HHHHCHHHHHHHHHH | 20415495 | ||
| 590 | Ubiquitination | KSMSTVLKNSDGSFR HHHHHHHHCCCCCEE | 22790023 | ||
| 604 | Phosphorylation | RIFSKGASEIILKKC EEECCCCHHHHHHHH | 24719451 | ||
| 613 | Ubiquitination | IILKKCFKILSANGE HHHHHHHHHHHCCCC | 22790023 | ||
| 622 | Ubiquitination | LSANGEAKVFRPRDR HHCCCCCEECCCCCH | 22790023 | ||
| 634 | Ubiquitination | RDRDDIVKTVIEPMA CCHHHHHHHHHHHHH | 22790023 | ||
| 703 | Phosphorylation | KCQRAGITVRMVTGD HHHHCCCEEEEECCC | 28059163 | ||
| 708 | Phosphorylation | GITVRMVTGDNINTA CCEEEEECCCCHHHH | 22802335 | ||
| 714 | Phosphorylation | VTGDNINTARAIATK ECCCCHHHHHHHHHH | 28059163 | ||
| 720 | Phosphorylation | NTARAIATKCGILHP HHHHHHHHHCCCCCC | 22802335 | ||
| 721 | Ubiquitination | TARAIATKCGILHPG HHHHHHHHCCCCCCC | 22790023 | ||
| 737 | Ubiquitination | DFLCLEGKDFNRRIR CEEEEECCHHHHHHH | 22790023 | ||
| 747 | Ubiquitination | NRRIRNEKGEIEQER HHHHHCCCCCCCHHH | 27667366 | ||
| 757 | Ubiquitination | IEQERIDKIWPKLRV CCHHHHHHHHHHHHH | 27667366 | ||
| 769 | Phosphorylation | LRVLARSSPTDKHTL HHHHHCCCCCCHHHH | - | ||
| 773 | Ubiquitination | ARSSPTDKHTLVKGI HCCCCCCHHHHHHHH | 27667366 | ||
| 778 | Ubiquitination | TDKHTLVKGIIDSTV CCHHHHHHHHHCCCC | 22790023 | ||
| 786 | Phosphorylation | GIIDSTVSEQRQVVA HHHCCCCCCCCCEEE | 20415495 | ||
| 799 | Phosphorylation | VAVTGDGTNDGPALK EEEECCCCCCCHHHH | 20415495 | ||
| 806 | Ubiquitination | TNDGPALKKADVGFA CCCCHHHHHCCCCEE | 27667366 | ||
| 806 | Acetylation | TNDGPALKKADVGFA CCCCHHHHHCCCCEE | 19846815 | ||
| 807 | Ubiquitination | NDGPALKKADVGFAM CCCHHHHHCCCCEEH | - | ||
| 826 | Phosphorylation | TDVAKEASDIILTDD CHHHHHHHCEEECCC | - | ||
| 837 | Phosphorylation | LTDDNFTSIVKAVMW ECCCCHHHHHHHHHC | 29899451 | ||
| 921 | Ubiquitination | RKPYGRNKPLISRTM CCCCCCCCCCCCHHH | 27667366 | ||
| 1034 | Phosphorylation | GGKPFSCSELSIEQW CCCCCCCCHHCHHHH | - | ||
| 1078 | Ubiquitination | EAGHGTQKEEIPEEE HCCCCCCHHHCCHHH | 22790023 | ||
| 1109 | Methylation | RGQILWFRGLNRIQT HCCEEEEECCCHHHH | 16185825 | ||
| 1109 | Dimethylation | RGQILWFRGLNRIQT HCCEEEEECCCHHHH | - | ||
| 1116 | Phosphorylation | RGLNRIQTQIRVVNA ECCCHHHHHHHHHHH | 29899451 | ||
| 1126 | Phosphorylation | RVVNAFRSSLYEGLE HHHHHHHHHHHHCCC | 26824392 | ||
| 1127 | Phosphorylation | VVNAFRSSLYEGLEK HHHHHHHHHHHCCCC | 26824392 | ||
| 1129 | Phosphorylation | NAFRSSLYEGLEKPE HHHHHHHHHCCCCCC | 25159016 | ||
| 1134 | Ubiquitination | SLYEGLEKPESRSSI HHHHCCCCCCCCHHH | - | ||
| 1137 | Phosphorylation | EGLEKPESRSSIHNF HCCCCCCCCHHHHHH | 27742792 | ||
| 1139 | Phosphorylation | LEKPESRSSIHNFMT CCCCCCCHHHHHHCC | 26824392 | ||
| 1140 | Phosphorylation | EKPESRSSIHNFMTH CCCCCCHHHHHHCCC | 26824392 | ||
| 1146 | Phosphorylation | SSIHNFMTHPEFRIE HHHHHHCCCCCCCCC | 26239621 | ||
| 1155 | Phosphorylation | PEFRIEDSEPHIPLI CCCCCCCCCCCCCCC | 27087446 | ||
| 1165 | Phosphorylation | HIPLIDDTDAEDDAP CCCCCCCCCCCCCCC | 27087446 | ||
| 1173 | Phosphorylation | DAEDDAPTKRNSSPP CCCCCCCCCCCCCCC | 22324799 | ||
| 1174 | Ubiquitination | AEDDAPTKRNSSPPP CCCCCCCCCCCCCCC | 27667366 | ||
| 1177 | Phosphorylation | DAPTKRNSSPPPSPN CCCCCCCCCCCCCCC | 27087446 | ||
| 1178 | Phosphorylation | APTKRNSSPPPSPNK CCCCCCCCCCCCCCC | 27087446 | ||
| 1182 | Phosphorylation | RNSSPPPSPNKNNNA CCCCCCCCCCCCCCC | 26824392 | ||
| 1192 | Phosphorylation | KNNNAVDSGIHLTIE CCCCCCCCCEEEEEE | 22817900 | ||
| 1197 | Phosphorylation | VDSGIHLTIEMNKSA CCCCEEEEEEECCCC | 25367039 | ||
| 1203 | Ubiquitination | LTIEMNKSATSSSPG EEEEECCCCCCCCCC | 27667366 | ||
| 1203 | Phosphorylation | LTIEMNKSATSSSPG EEEEECCCCCCCCCC | 26643407 | ||
| 1205 | Phosphorylation | IEMNKSATSSSPGSP EEECCCCCCCCCCCC | 26239621 | ||
| 1206 | Phosphorylation | EMNKSATSSSPGSPL EECCCCCCCCCCCCC | 26239621 | ||
| 1207 | Phosphorylation | MNKSATSSSPGSPLH ECCCCCCCCCCCCCH | 26643407 | ||
| 1208 | Phosphorylation | NKSATSSSPGSPLHS CCCCCCCCCCCCCHH | 26643407 | ||
| 1211 | Phosphorylation | ATSSSPGSPLHSLET CCCCCCCCCCHHHCC | 25177544 | ||
| 1215 | Phosphorylation | SPGSPLHSLETSL-- CCCCCCHHHCCCC-- | 27717184 | ||
| 1218 | Phosphorylation | SPLHSLETSL----- CCCHHHCCCC----- | 26160508 | ||
| 1219 | Phosphorylation | PLHSLETSL------ CCHHHCCCC------ | 23984901 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 1116 | T | Phosphorylation | Kinase | PKC | - | Uniprot |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AT2B1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AT2B1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ITPR3_MOUSE | Itpr3 | physical | 16352659 | |
| AT2A2_MOUSE | Atp2a2 | physical | 16352659 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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