ITPR3_MOUSE - dbPTM
ITPR3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ITPR3_MOUSE
UniProt AC P70227
Protein Name Inositol 1,4,5-trisphosphate receptor type 3
Gene Name Itpr3
Organism Mus musculus (Mouse).
Sequence Length 2670
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium..
Protein Sequence MNEMSSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPMNRYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGSVIQLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVGDKVILNPVNAGQPLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDVVRLFHAEQEKFLTCDEYRGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGLYRFKHLATGNYLAAEENPSYKGDVSDPKAAGLGAQGRTGRRNAGEKIKYRLVAVPHGNDIASLFELDPTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNAPIDVEEERPIRLMLGTCPTKEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLEDLVFFVSDVPNNGQNVLDIMVTKPNRERQKLMREQNILKQIFGILKAPFRDKGGEGPLVRLEELSDQKNAPYQYMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNNRKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNRIAIPVTQELICKCVLDPKNSDILIQTELRPVKEMAQSHEYLSIEYSEEEVWLTWTDRNNEHHEKSVRQLAQEARAGNAHDENVLSYYRYQLKLFARMCLDRQYLAIDEISKQLGVELLFLCMADEMLPFDLRASFCHLMLHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDSNLNASRDDKKNKFASTMEFVEDYLNNVVSEAVPFANDEKNILTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCIQAPAAMLQAYEEPGGKNVRRSIQGVGHMMSTMVLSRKQSVFGASSLPAGVGVPEQLDRSKFEDNEHTVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPMQDSGADGTAPAFDSSTATMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLLHLTMHDYPSLVSGALQLLFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWVDKKGSVKGEEVEAGATKDKKERPSDEEGFLQPHGEKSSENYQIVKGILERLNKMCGVGEQMRKKQQRLLKNMDAHKVMLDLLQIPYDKSDNKMLEILRYTHQFLQKFCAGNPGNQALLHKHLQLFLTPGLLEAETMQHIFLNNYQLCSEISEPVLQHFVHLLATHGRHVQYLDFLHTVIKAEGKYVKKCQDMIMTELTNAGDDVVVFYNDKASLAHLLDMMKAARDGVEDHSPLMYHISLVDLLAACAEGKNVYTEIKCTSLLPLEDVVTVVTHEDCITEVKMAYVNFVNHCYVDTEVEMKEIYTSNHIWTLFENFTLDMALVCNKREKRLSDPTLEKYVLTVVLDTISAFFSSPFSENSTSLQTHQTIVVQLLQSTTRLLECPWLQQQHKGSVEACVRTLAMVAKSRAILLPMDLDAHMSALLSSGGSCSAAAQRSAANYKTATRTFPRVIPTANQWDYKNIIEKLQDIIMALEERLKPLVQAELSVLVDMLHWPELLFPEGSEAYQRCESGGFLSKLIRHTKGLMESEEKLCVKVLRTLQQMLLKKSKFGDRGNQLRKMLLQNYLQNRKSGARGELTDPTGSGLDQDWSAIAATQCRLDKEGATKLVCDLITSTKNEKIFQESIGLAIRLLDGGNTEIQKSFYNLMTSDKKSERFFKVLHDRMKRAQQETKSTVAVNMSDLGSQPREDREPADPATKGRVSSFSMPSSSRYLLGLGLHRGHDMSERAQNNEMGTSVLIMRPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDIMCGSTTGGLGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQTCIVTHESNGIDIITALILNDISPLCKYRMDLVLQLKDNASKLLLALMESRHDSENAERILISLRPQELVDVIKKAYLQEEERENSEVSPREVGHNIYILALQLSRHNKQLQHLLKPVRRIQEEEAEGISSMLSLNNKQLSQMLKSSAPAQEEEEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPAICQFLTEETKHRLFTTTEQDEQGSKVSDFFDQSSFLHNEMEWQRRLRSMPLIYWFSRRMTLWGSISFNLAVFINIIIAFFYPYVEGASTGVLGSPLISLLFWILICFSIAALFTKRYSVRPLIVALILRSIYYLGIGPTLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVGYILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIVGFLFLKDDFILEVDRLPGNHSRASPLGMPHGAATFMGTCSGDKMDCVSEVSVPEILEEDEEPDSTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKLEHNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSGEGEGEQNEIRILQEKLGSTMKLVSHLTSQLNELKEQMTEQRKRRQRLGFVDVQNCMSR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
132PhosphorylationLHMKSNKYLTVNKRL
EECCCCCEEEECCCH		16.32-
134PhosphorylationMKSNKYLTVNKRLPA
CCCCCEEEECCCHHH		20.95-
145UbiquitinationRLPALLEKNAMRVTL
CHHHHHHHCCEEEEE		50.4027667366
208UbiquitinationLSDNAGCKEVNSVNC
CCCCCCCCCCCEECC		64.87-
246UbiquitinationDVVRLFHAEQEKFLT
CEEEEEECCCCCCCC		16.9127667366
328PhosphorylationPSYKGDVSDPKAAGL
CCCCCCCCCHHHCCC		53.5922802335
542PhosphorylationLVRLEELSDQKNAPY
EEEHHHHCCCCCCCH		41.0727180971
795PhosphorylationRDPQELVTPVKFARL
CCHHHCCCHHHHHHH		34.6821454597
804PhosphorylationVKFARLWTEIPTAIT
HHHHHHHCCCCCEEE		28.7321454597
916PhosphorylationGGKNVRRSIQGVGHM
CCHHHHHHHHHHHHH		14.5426824392
925PhosphorylationQGVGHMMSTMVLSRK
HHHHHHHHHHHHCCC		13.0328833060
926PhosphorylationGVGHMMSTMVLSRKQ
HHHHHHHHHHHCCCC		8.0628833060
930PhosphorylationMMSTMVLSRKQSVFG
HHHHHHHCCCCCCCC		26.4828833060
934PhosphorylationMVLSRKQSVFGASSL
HHHCCCCCCCCCCCC		23.5827087446
939PhosphorylationKQSVFGASSLPAGVG
CCCCCCCCCCCCCCC		32.5527742792
940PhosphorylationQSVFGASSLPAGVGV
CCCCCCCCCCCCCCC		37.5327087446
1133PhosphorylationLWVDKKGSVKGEEVE
CEECCCCCCCCEEEC		29.5426824392
1152PhosphorylationKDKKERPSDEEGFLQ
CCCCCCCCCCCCCCC		64.9721030605
1657PhosphorylationHTKGLMESEEKLCVK
HCCCCCCCHHHHHHH		36.7728464351
1700PhosphorylationNYLQNRKSGARGELT
HHHHCCCCCCCCCCC		34.1529514104
1707PhosphorylationSGARGELTDPTGSGL
CCCCCCCCCCCCCCC		35.31-
1813PhosphorylationVNMSDLGSQPREDRE
ECHHHCCCCCCCCCC		44.29-
1831PhosphorylationPATKGRVSSFSMPSS
CCCCCCCCCCCCCCC		25.0623684622
1832PhosphorylationATKGRVSSFSMPSSS
CCCCCCCCCCCCCCH		20.6225521595
1834PhosphorylationKGRVSSFSMPSSSRY
CCCCCCCCCCCCHHH		31.5625619855
1837PhosphorylationVSSFSMPSSSRYLLG
CCCCCCCCCHHHHHH		32.1025619855
1838PhosphorylationSSFSMPSSSRYLLGL
CCCCCCCCHHHHHHC		16.9925619855
1839PhosphorylationSFSMPSSSRYLLGLG
CCCCCCCHHHHHHCC		29.3125619855
2189PhosphorylationEWQRRLRSMPLIYWF
HHHHHHHHCCHHHHH		29.3722817900
2456PhosphorylationSTERACDTLLMCIVT
CHHHHHHHHHHHHHH		22.9828059163
2463PhosphorylationTLLMCIVTVMNHGLR
HHHHHHHHHHHCCCC		8.3028059163
2529UbiquitinationLRSEKQKKEEILKTT
HHCHHHHHHHHHHHH		59.0727667366
2608PhosphorylationFPRMRAMSLVSGEGE
HHHHHHHHCCCCCCC		25.3226239621
2656UbiquitinationMTEQRKRRQRLGFVD
HHHHHHHHHHHCCCC		29.0727667366
2669PhosphorylationVDVQNCMSR------
CCHHHHCCC------		36.7227087446
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ITPR3_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ITPR3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ITPR3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UBC_HUMANUBCphysical
12421829
CAV1_MOUSECav1physical
17416589
TRPC4_MOUSETrpc4physical
17416589
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ITPR3_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-934 AND SER-1152, ANDMASS SPECTROMETRY.

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