TRPC4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRPC4_MOUSE
• UniProt AC: Q9QUQ5
• Protein Name: Short transient receptor potential channel 4
• Gene Name: Trpc4
• Organism: Mus musculus (Mouse).
• Sequence Length: 974
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Cell membrane; Multi-pass membrane protein.
• Protein Description: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. Trpc4 deficient mice lack a store-operated calcium entry in endothelial cells..
• Protein Sequence: MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLSCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLVKWIWTHLCKKKMRRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAAMIREAKTEEGLTEENVKELKQDISSFRFEVLGLLRGSKLSTIQSANAASSADSDEKSQSEGNGKDKRKNLSLFDLTTLIHPRSAAIASERHNLSNGSALVVQEPPREKQRKVNFVADIKNFGLFHRRSKQNAAEQNANQIFSVSEEITRQQAAGALERNIELESKGLASRGDRSIPGLNEQCVLVDHRERNTDTLGLQVGKRVCSTFKSEKVVVEDTVPIIPKEKHAHEEDSSIDYDLSPTDTAAHEDYVTTRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
497	Phosphorylation	LRLISLFTANSHLGP HHHHHHHHCCCCCCH	30.17	20139300
688	Phosphorylation	KMRRKPESFGTIGRR HHHCCCHHCCHHHHH	37.19	28059163
691	Phosphorylation	RKPESFGTIGRRAAD CCCHHCCHHHHHHHH	20.46	-
717	Phosphorylation	MRNLVKRYVAAMIRE HHHHHHHHHHHHHHH	6.68	-
956	Phosphorylation	EEDSSIDYDLSPTDT CCCCCCCCCCCCCCC	19.67	-
959	Phosphorylation	SSIDYDLSPTDTAAH CCCCCCCCCCCCCCC	23.90	-
963	Phosphorylation	YDLSPTDTAAHEDYV CCCCCCCCCCCHHHC	28.37	-
969	Phosphorylation	DTAAHEDYVTTRL-- CCCCCHHHCCCCC--	9.19	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
956	Y	Phosphorylation	Kinase	FYN	P39688	Uniprot
969	Y	Phosphorylation	Kinase	FYN	P39688	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRPC4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRPC4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ITPR1_MOUSE	Itpr1	physical	17416589
ITPR3_MOUSE	Itpr3	physical	17416589
TRPC1_MOUSE	Trpc1	physical	17416589
CAV1_MOUSE	Cav1	physical	17416589

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.