TRPC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRPC1_MOUSE
• UniProt AC: Q61056
• Protein Name: Short transient receptor potential channel 1
• Gene Name: Trpc1
• Organism: Mus musculus (Mouse).
• Sequence Length: 793
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion..
• Protein Sequence: MMAALYPSTDLSGVSSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENESLDILQLLLDYGCQSADALLVAIDSEVVGAVDILLNHRPKRSSRPTIVKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPRN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
89 (in isoform 2)	Phosphorylation	-	15.25	25777480
91 (in isoform 2)	Phosphorylation	-	16.93	25777480
96 (in isoform 2)	Phosphorylation	-	42.81	25777480
106 (in isoform 2)	Phosphorylation	-	21.55	25777480
279	Phosphorylation	LLAQARNSRELEVIL HHHHHHCCCCCCHHH	22.90	30482847
396	Phosphorylation	IHGASYFTFLLLLNL HCHHHHHHHHHHHHH	12.73	-
689	Acetylation	FNIIPSPKTICYMIS CCCCCCHHHHHHHHH	55.66	6597403

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRPC1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRPC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRPC1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TRPC1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.