MTMR5_MOUSE - dbPTM
MTMR5_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MTMR5_MOUSE
UniProt AC Q6ZPE2
Protein Name Myotubularin-related protein 5
Gene Name Sbf1
Organism Mus musculus (Mouse).
Sequence Length 1867
Subcellular Localization Nucleus.
Protein Description Probable pseudophosphatase. Lacks several amino acids in the catalytic pocket which renders it catalytically inactive as a phosphatase. The pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts. Alternatively proposed to function as a guanine nucleotide exchange factor (GEF) activating RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity)..
Protein Sequence MARLADYFVLVAFGPHPRGSGEGQGQILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPERNPPTFFVAVLTDINSERHYCACLTFWEPVESTQEVVCTDNATEKEEEADGGGQARLSSTAPAQPGQLFAPKTLVLVSRLDHAEVFRNSLGLIYAIHVEGLNVSLENVIGNLLTCTVPLAGGSQRTISLGAGDRQVIQTPLVDSLPVSRCSVALLFRQLGITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAETQELLDVIVADLDGGTVTVPECVHIPPLPEPLQSQTHNVLSMVLDPELELADLAFPPPTTSASSLKMQDKELRAVFLRLFAQLLQGYRWCLHIVRIHPEPVIRFHKAAFLGQRGLVEDDFLMKVLEGMAFAGFVSERGVPYRATDLFDELVAHEVARMRADESHPHRVLRHVQELAEQLYKNENPYPAVAMHKVQRPGEASHLRRTHRPFPRLDEGTIQWIVDQAAAKMQGAPPAVKAERRSTVPSGPPMTAILERCSGPHINSARRLEVVRNCISYVFEGKMLEAKKLLPAVLRALKGRAARRCLAHELHLHVQQNRAVLDHQQFDFVVRMMNCCLQDCTSLDEHGIASALLPLVTAFCRKLSPGVTQFAYSCVQEHVVWSTPQFWEAMFYGDVQTHIRALYLEPSDGVSPTQETGEAQSQDDERSALDVASEQRRLWPTLSREKQQELVQKEESTVFSQAIHYANRMSYLLLPLDSSKSRLLRERAGLGDLESASNSLVTNSMAGSVAESYDTESGFEDAETCDVAGAVVRFINRFVDKVCTESGVTSDHLKGLHVMVPDIVQMHIETLEAVHRESKRLPPIQKPKLLRPRLLPGEECVLDGLRVYLLPDGREEGVGGSGGGPALLPAEGAVFLTTYRVIFTGMPTDPLVGEQVVVRSFPVAALTKEKRISVQTPVDQLLQDGLQLRSCTFQLLKMAFDEEVGSDSAELFRKQLHKLRYPPDIRATFAFTLGSAHTPGRPPRVTKDKGPSFRTLSRNLMKNAKKTIGRQYVTRKKYNPPGWEHRGQPPPEDQEDEISVSEELEPSTLTPSSALKPSDRMTMSSLVERACCRDYQRLGLGTLSSSLSRAKSEPFRISPVNRMYAICRSYPGLLIVPQSIQDNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRSGGLHGKGVVGLFKAQNTPSPGQAQADSSSLEQEKYLQAVVSSMPRYADSSGRNTLSSFSSAHMGGHGKWSSVRASGRSSGLGSDVGSRLAGRDLLSTPHTNGAPPDSGFLRPQRAALYIIGDKAQLKGVRPDPLQQWELVPIEVFEARQVKASFKKLLKACVPGCPATEPSPASFLRSLEDSEWLIQIHKLLQISVLVVELLDSGSSVLVSLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAGQSSGFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHTSRRFRTFLLDSDYERIELGLLYEEKGERRGQLACKSVWEYVDRLSKRTPMFYNYTYAPEDTEVLRPYSNVSNLKVWDFYTEETLAEGPPYDWELAQGPPEPPEEERPDGGAPQSRRRVVWPCYDSRPRVQPDAISRLLEELQRLETELGRPSERWKDTWDRVKAAQRLESRQDGRGTPSSLLVSAVPHHRRSLGVYLQEGPVGSTLSLSLDSDQSSGSTTSSSRQAARRSTSTLYSQFQTAESENRSYEGILYKKGAFMKPWKARWFVLDKTKHQLRYYDHRMDTECKGVIDLAEVEAVAPGTPTIGAPKTVDEKAFFDVKTTRRVYNFCAQDVPSAQQWVDRIQSCLSDA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
20PhosphorylationFGPHPRGSGEGQGQI
ECCCCCCCCCCCCCH		34.6428833060
64PhosphorylationCPERNPPTFFVAVLT
CCCCCCCCEEEEEEE		30.8426239621
71PhosphorylationTFFVAVLTDINSERH
CEEEEEEECCCCCCC		28.3826239621
75PhosphorylationAVLTDINSERHYCAC
EEEECCCCCCCEEEE		36.0226239621
131UbiquitinationPGQLFAPKTLVLVSR
CCCCCCCCEEEEEEC		51.5722790023
131UbiquitinationPGQLFAPKTLVLVSR
CCCCCCCCEEEEEEC		51.5722790023
187PhosphorylationGGSQRTISLGAGDRQ
CCCCEEEECCCCCCE		21.8225338131
203PhosphorylationIQTPLVDSLPVSRCS
EECCCCCCCCCCHHH		27.39-
308UbiquitinationDVIVADLDGGTVTVP
HEEEEECCCCEEECC		54.7627667366
401UbiquitinationEPVIRFHKAAFLGQR
CCCHHHHHHHHHCCC		38.4022790023
401UbiquitinationEPVIRFHKAAFLGQR
CCCHHHHHHHHHCCC		38.4022790023
409UbiquitinationAAFLGQRGLVEDDFL
HHHHCCCCCCCHHHH		26.6227667366
496PhosphorylationVQRPGEASHLRRTHR
CCCCCCHHHHCCCCC		20.8220531401
512PhosphorylationFPRLDEGTIQWIVDQ
CCCCCHHCHHHHHHH		14.1429899451
537PhosphorylationAVKAERRSTVPSGPP
CCHHHHHCCCCCCCC		39.7225338131
538PhosphorylationVKAERRSTVPSGPPM
CHHHHHCCCCCCCCC		34.3225521595
553PhosphorylationTAILERCSGPHINSA
CHHHHHCCCCCCCHH		62.67-
559PhosphorylationCSGPHINSARRLEVV
CCCCCCCHHHHHHHH		23.6625521595
698PhosphorylationQTHIRALYLEPSDGV
HHHEEEEEECCCCCC		14.1830635358
702PhosphorylationRALYLEPSDGVSPTQ
EEEEECCCCCCCCCC		37.3124925903
706PhosphorylationLEPSDGVSPTQETGE
ECCCCCCCCCCCCCC		27.9725521595
708PhosphorylationPSDGVSPTQETGEAQ
CCCCCCCCCCCCCCC		31.3725521595
711PhosphorylationGVSPTQETGEAQSQD
CCCCCCCCCCCCCCC		30.4230635358
716PhosphorylationQETGEAQSQDDERSA
CCCCCCCCCCHHHHH		42.5024925903
728PhosphorylationRSALDVASEQRRLWP
HHHHHHHHHHHHHHH		33.8329899451
775UbiquitinationLLPLDSSKSRLLRER
EEECCCHHHHHHHHH		43.4722790023
775UbiquitinationLLPLDSSKSRLLRER
EEECCCHHHHHHHHH		43.4722790023
788UbiquitinationERAGLGDLESASNSL
HHCCCCCHHHHHHHH		5.4827667366
881UbiquitinationKRLPPIQKPKLLRPR
CCCCCCCCCCCCCCC		44.8527667366
889UbiquitinationPKLLRPRLLPGEECV
CCCCCCCCCCCCEEE		8.1927667366
968PhosphorylationLTKEKRISVQTPVDQ
CCCCCCCCCCCCHHH		16.5322324799
971PhosphorylationEKRISVQTPVDQLLQ
CCCCCCCCCHHHHHH		24.1120415495
1027PhosphorylationIRATFAFTLGSAHTP
HHHEEEEECCCCCCC		27.1226643407
1030PhosphorylationTFAFTLGSAHTPGRP
EEEEECCCCCCCCCC		21.7126643407
1033PhosphorylationFTLGSAHTPGRPPRV
EECCCCCCCCCCCCC		27.4426643407
1047 (in isoform 2)Phosphorylation-35.7124719451
1047PhosphorylationVTKDKGPSFRTLSRN
CCCCCCCCHHHHCHH		35.7122324799
1050PhosphorylationDKGPSFRTLSRNLMK
CCCCCHHHHCHHHHH		27.3729514104
1067PhosphorylationKKTIGRQYVTRKKYN
HHHHCCHHCCCCCCC		11.4829514104
1094PhosphorylationEDQEDEISVSEELEP
CCCCCCCCCCCCCCC		19.9723140645
1117PhosphorylationLKPSDRMTMSSLVER
CCCCCCCCHHHHHHH		18.1323737553
1119PhosphorylationPSDRMTMSSLVERAC
CCCCCCHHHHHHHHH		16.0223737553
1120PhosphorylationSDRMTMSSLVERACC
CCCCCHHHHHHHHHC		26.1323737553
1137PhosphorylationYQRLGLGTLSSSLSR
HHHHCHHHHCHHHHH		28.6325521595
1139PhosphorylationRLGLGTLSSSLSRAK
HHCHHHHCHHHHHHC		20.0922942356
1140PhosphorylationLGLGTLSSSLSRAKS
HCHHHHCHHHHHHCC		38.1126824392
1141PhosphorylationGLGTLSSSLSRAKSE
CHHHHCHHHHHHCCC		27.3023527152
1143PhosphorylationGTLSSSLSRAKSEPF
HHHCHHHHHHCCCCC		31.9422942356
1222MethylationKGVVGLFKAQNTPSP
CCEEEEEECCCCCCC		54.85-
1226PhosphorylationGLFKAQNTPSPGQAQ
EEEECCCCCCCCCCC		17.0528066266
1228PhosphorylationFKAQNTPSPGQAQAD
EECCCCCCCCCCCCC		39.3628066266
1236PhosphorylationPGQAQADSSSLEQEK
CCCCCCCCCHHHHHH		25.4928066266
1237PhosphorylationGQAQADSSSLEQEKY
CCCCCCCCHHHHHHH		39.2228066266
1238PhosphorylationQAQADSSSLEQEKYL
CCCCCCCHHHHHHHH		39.6228066266
1244PhosphorylationSSLEQEKYLQAVVSS
CHHHHHHHHHHHHHC		11.8625777480
1250PhosphorylationKYLQAVVSSMPRYAD
HHHHHHHHCCCCCCC		17.8325777480
1251PhosphorylationYLQAVVSSMPRYADS
HHHHHHHCCCCCCCC		22.6125777480
1263 (in isoform 2)Phosphorylation-27.02-
1263PhosphorylationADSSGRNTLSSFSSA
CCCCCCCCHHHCCCC		27.02-
1269 (in isoform 2)Phosphorylation-21.8627681418
1278 (in isoform 2)Phosphorylation-10.6329514104
1285 (in isoform 2)Phosphorylation-32.2929514104
1287 (in isoform 2)Phosphorylation-32.0829514104
1288PhosphorylationVRASGRSSGLGSDVG
CCCCCCCCCCCCCHH		36.3529899451
1306 (in isoform 2)Phosphorylation-21.0429514104
1310 (in isoform 2)Phosphorylation-41.4129514104
1314 (in isoform 2)Phosphorylation-48.1129514104
1583PhosphorylationDTEVLRPYSNVSNLK
CCCCCCCCCCCCCCE		13.3724759943
1584PhosphorylationTEVLRPYSNVSNLKV
CCCCCCCCCCCCCEE		33.1824759943
1587PhosphorylationLRPYSNVSNLKVWDF
CCCCCCCCCCEEEEE		40.4724759943
1693PhosphorylationSRQDGRGTPSSLLVS
HCCCCCCCCHHHHHH		20.7321743459
1695PhosphorylationQDGRGTPSSLLVSAV
CCCCCCCHHHHHHCC		33.1921743459
1696PhosphorylationDGRGTPSSLLVSAVP
CCCCCCHHHHHHCCC		27.2521743459
1746PhosphorylationSRQAARRSTSTLYSQ
HHHHHHHHHHHHHHH		22.5825521595
1747PhosphorylationRQAARRSTSTLYSQF
HHHHHHHHHHHHHHH		24.7423737553
1748PhosphorylationQAARRSTSTLYSQFQ
HHHHHHHHHHHHHHH		20.0525521595
1749PhosphorylationAARRSTSTLYSQFQT
HHHHHHHHHHHHHHC		29.7825521595
1751PhosphorylationRRSTSTLYSQFQTAE
HHHHHHHHHHHHCCC		10.6626160508
1752PhosphorylationRSTSTLYSQFQTAES
HHHHHHHHHHHCCCC		27.8627600695
1756PhosphorylationTLYSQFQTAESENRS
HHHHHHHCCCCCCCC		33.4123737553
1764PhosphorylationAESENRSYEGILYKK
CCCCCCCEEEEEEEC		18.22-
1769PhosphorylationRSYEGILYKKGAFMK
CCEEEEEEECCCCCC		14.56-
1770UbiquitinationSYEGILYKKGAFMKP
CEEEEEEECCCCCCC		41.0922790023
1770UbiquitinationSYEGILYKKGAFMKP
CEEEEEEECCCCCCC		41.0922790023
1819PhosphorylationVEAVAPGTPTIGAPK
EEEECCCCCCCCCCC		19.0526745281
1821PhosphorylationAVAPGTPTIGAPKTV
EECCCCCCCCCCCCC		31.7026745281
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MTMR5_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MTMR5_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MTMR5_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MTMR5_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MTMR5_MOUSE

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1749, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory