| UniProt ID | PP2BC_MOUSE | |
|---|---|---|
| UniProt AC | P48455 | |
| Protein Name | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform | |
| Gene Name | Ppp3cc | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 513 | |
| Subcellular Localization | ||
| Protein Description | Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32.. | |
| Protein Sequence | MSVRRPQFSTTERVIKAVPFPPTRRLTLKEVFENGKPKMDLLKNHLVKEGRVEEEVALKIINDGAAILKQEKTMIEVEAPITVCGDVHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTEYFTFKQECRIKYSEMVYDACMHTFDCLPLAALLNQQFLCVHGGMSPEITCLEDIRKLDRFSEPPAFGPVCDLLWSDPLEDYGSEKTLEHYTHNTVRGCSYFFSYPAVCEFLQNNSLLSIIRAHEAQDAGYRMYRKNQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDEEMNVTDEEGATTGRKEVIKNKIRAIGKMARVFTVLREESENVLTLKGLTPTGTLPLGVLSGGKQTIETAKQEAAEEREAIRGFTIAHRIRSFEEARGLDRINERMPPRKEASYHHDAGRMHSHSHPPHPQASRRTDHGKKAL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSVRRPQFS ------CCCCCCCCC | 25.08 | 29514104 | |
| 139 | Phosphorylation | LKINHPKTLFLLRGN CCCCCCCEEEEECCC | 27.48 | 29899451 | |
| 284 | Phosphorylation | HEAQDAGYRMYRKNQ HHHHHHCHHHHHHCC | 8.23 | 29899451 | |
| 319 | Ubiquitination | NNKAAVLKYENNVMN CCCEEEEEEECCEEC | 43.87 | - | |
| 386 | Acetylation | EGATTGRKEVIKNKI CCCCCCCHHHHHHHH | 58.64 | 22902405 | |
| 462 | Phosphorylation | TIAHRIRSFEEARGL HHHHHHHCHHHHCCC | 34.34 | 24704852 | |
| 483 | Phosphorylation | MPPRKEASYHHDAGR CCCCCCCCCCCCCCC | 26.54 | 29899451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PP2BC_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PP2BC_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PP2BC_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PP2BC_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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