dbPTM

PDE1B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PDE1B_MOUSE
UniProt AC	Q01065
Protein Name	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Gene Name	Pde1b
Organism	Mus musculus (Mouse).
Sequence Length	535
Subcellular Localization	Cytoplasm.
Protein Description	Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate (By similarity)..
Protein Sequence	MELSPRSPPEMLESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEVNIEELKKNLEYTASLLEAVYIDETRQILDTEDELRELRSDAVPSEVRDWLASTFTQQTRAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVHNCLKNLDLWCFDVFSLNRAADDHALRTIVFELLTRHSLISRFKIPTVFLMSFLEALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSECAILYNDRSVLENHHISSVFRMMQDDEMNIFINLTKDEFAELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKSKALSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLADDDSKPKSQPSFQWRQPSLDVDVGDPNPDVVSFRATWTKYIQENKQKWKERAASGITNQMSIDELSPCEEEAPSSPAEDEHNQNGNLD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MELSPRSPPEM ----CCCCCCCCHHH	12.64	24719451
7	Phosphorylation	-MELSPRSPPEMLES -CCCCCCCCHHHHHC	48.46	25521595
14	Phosphorylation	SPPEMLESDCPSPLE CCHHHHHCCCCCCCC	40.32	22817900
18	Phosphorylation	MLESDCPSPLELKSA HHHCCCCCCCCCCCC	48.74	22817900
406	Phosphorylation	AELGLPFSPLCDRTS CHHCCCCCCCCCCCC	18.28	22817900
465	Phosphorylation	SFQWRQPSLDVDVGD CCCCCCCCCCCCCCC	28.94	25521595
504	Phosphorylation	ERAASGITNQMSIDE HHHHCCCCCCCCHHH	23.95	29899451
508	Phosphorylation	SGITNQMSIDELSPC CCCCCCCCHHHCCCC	19.68	22817900
513	Phosphorylation	QMSIDELSPCEEEAP CCCHHHCCCCCCCCC	26.00	25521595
521	Phosphorylation	PCEEEAPSSPAEDEH CCCCCCCCCCCCCCC	56.87	19060867
522	Phosphorylation	CEEEAPSSPAEDEHN CCCCCCCCCCCCCCC	27.37	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PDE1B_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PDE1B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PDE1B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PDE1B_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PDE1B_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-465, AND MASSSPECTROMETRY.	15345747 [Abstract]