PADI2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PADI2_MOUSE
• UniProt AC: Q08642
• Protein Name: Protein-arginine deiminase type-2
• Gene Name: Padi2
• Organism: Mus musculus (Mouse).
• Sequence Length: 673
• Subcellular Localization: Cytoplasm.
• Protein Description: Catalyzes the deimination of arginine residues of proteins..
• Protein Sequence: MQPPIRENMLRERTVRLQYGSRVEAVYVLGTQLWTDVYSAAPAGAKTFSLKHSEGVKVEVVRDGEAEEVVTNGKQRWALSPSSTLRLSMAQASTEASSDKVTVNYYEEEGSAPIDQAGLFLTAIEISLDVDADRDGEVEKNNPKKASWTWGPEGQGAILLVNCDRDTPWLPKEDCSDEKVYSKQDLQDMSQMILRTKGPDRLPAGYEIVLYISMSDSDKVGVFYVENPFFGQRYIHILGRQKLYHVVKYTGGSAELLFFVEGLCFPDESFSGLVSIHVSLLEYMAEGIPLTPIFTDTVMFRIAPWIMTPNILPPVSVFVCCMKDNYLFLKEVKNLVEKTNCELKVCFQYMNRGDRWIQDEIEFGYIEAPHKGFPVVLDSPRDGNLKDFPIKQLLGPDFGYVTREPLFETVTSLDSFGNLEVSPPVTVNGKEYPLGRILIGSSFPLSGGRRMTKVVRDFLQAQQVQAPVELYSDWLTVGHVDEFMTFIPIPGKKEFRLLMASTSACYQLFREKQKAGHGEAVMFKGLGGMSSKRITINKILSNESLTQENQYFQRCLDWNRDILKRELALTEKDIIDLPALFKMDENHQARAFFPNMVNMIVLDKDLGIPKPFGPQVEEECCLETHVRGLLEPLGLACTFIDDISAYHKFLGEVHCGTNVRRKPFTFKWWHMVP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MQPPIREN -------CCCCHHHH	14.07	8354274
80	Phosphorylation	GKQRWALSPSSTLRL CCEEEEECCHHHHHH	18.26	28059163
98	Phosphorylation	QASTEASSDKVTVNY HHHCCCCCCCEEEEE	48.80	24759943
183	Ubiquitination	SDEKVYSKQDLQDMS CCCCCCCHHHHHHHH	30.09	22790023
352	Citrullination	VCFQYMNRGDRWIQD EHHHHCCCCCCEEEE	31.68	-
352	Citrullination	VCFQYMNRGDRWIQD EHHHHCCCCCCEEEE	31.68	8354274
386	Ubiquitination	SPRDGNLKDFPIKQL CCCCCCCCCCCHHHH	62.41	22790023
532	Acetylation	GLGGMSSKRITINKI CCCCCCCCEEEHHHH	40.28	7613093
541	Phosphorylation	ITINKILSNESLTQE EEHHHHHCCCCCCCH	41.86	21454597
544	Phosphorylation	NKILSNESLTQENQY HHHHCCCCCCCHHHH	40.75	28464351
546	Phosphorylation	ILSNESLTQENQYFQ HHCCCCCCCHHHHHH	43.02	21454597
551	Phosphorylation	SLTQENQYFQRCLDW CCCCHHHHHHHHHHC	17.17	21454597
582	Ubiquitination	IDLPALFKMDENHQA CCHHHHHCCCCCHHH	46.41	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PADI2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PADI2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PADI2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PADI2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"cDNA nucleotide sequence and primary structure of mouse uterinepeptidylarginine deiminase. Detection of a 3'-untranslated nucleotidesequence common to the mRNA of transiently expressed genes and rapidturnover of this enzyme's mRNA in the estrous cycle.";
Tsuchida M., Takahara H., Minami N., Arai T., Kobayashi Y.,Tsujimoto H., Fukazawa C., Sugawara K.;
Eur. J. Biochem. 215:677-685(1993).
Cited for: NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
PubMed: 8354274

Citrullination

"cDNA nucleotide sequence and primary structure of mouse uterinepeptidylarginine deiminase. Detection of a 3'-untranslated nucleotidesequence common to the mRNA of transiently expressed genes and rapidturnover of this enzyme's mRNA in the estrous cycle.";
Tsuchida M., Takahara H., Minami N., Arai T., Kobayashi Y.,Tsujimoto H., Fukazawa C., Sugawara K.;
Eur. J. Biochem. 215:677-685(1993).
Cited for: NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
PubMed: 8354274