CAMP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAMP2_MOUSE
• UniProt AC: Q8C1B1
• Protein Name: Calmodulin-regulated spectrin-associated protein 2 {ECO:0000305}
• Gene Name: Camsap2 {ECO:0000312|MGI:MGI:1922434}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1461
• Subcellular Localization: Cytoplasm, cytoskeleton . Golgi apparatus . Associated with the minus-end of microtubules and also detected at the centrosomes. Decorates the minus-end of microtubules by decreasing the rate of tubulin incorporation and remaining bound. The length of
• Protein Description: Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. [PubMed: 23169647 Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (By similarity Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (By similarity In addition, it also reduces the velocity of microtubule polymerization (By similarity Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (By similarity Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (By similarity Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (By similarity Through the microtubule cytoskeleton, regulates the autophagosome transport (By similarity]
• Protein Sequence: MGDAADPREMRRTFIVPAIKPFDHYDFSRAKIACNLAWLVAKAFGTENVPEELGDPFYTDQYDQEHIKPPVVNLLLSAELYCRAGSLILKSDAAKPLLGHDAVIQALAQKGLYVTDQEKLVTERDLHKKPIQMSAHLAMIDTLMMAYTVEMISIEKVIACAQQYSAFFQATDLPYDIEDAVMYWMNKVNEHLKDIMEQEQKSKEHHPAEAPGGQKARYRKEQTLLKQLPCIPLVENLLKDGTDGCALAALIHFYCPAVVRLEDICLKETMSLADSLYNLQLIQEFCQEYLNHCCHFSLEDMLYAASSIKSNYLVFMAELFWWFEVVKPSFVQPRVVRPQGAEPAKDVPSVPVLNAAKRNIRDSSSSSDFSSRYTRPQTHSSASGGIRRSSSMSYVDGFIGTWPKEKRTSVHGVSFDISFDKEDSAQSSTPNRGIIRSVSNEGLTLNNSRASKHIRKNLSFKPVNGEEEESIEEELHVDPHGDLQSPMPLNTNELNSNESTHYKLPNGALQNRVLLDEFGNQIETPSIEEALQIIHDTERPPHTPRPDQIANGFFLHGQDLSILNSNIKLNQSSPDNLTDTKGALSPITDTTEVDTGIHVPSEDIPETMDEDSSLRDYTVSLDSDMDDASKLLQDYDLRASNPREALSPCPSTISTKSQPGSSASSSSGVKMTSFAEQKFRKLNHTDGKSSGSSSQKTTPEGSELNIPHVVSWAQIPEEAGVAPGRDTTQLLASEMVHLRMRLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGEGISPLREEAAGAEDEKVYTDRAKERESQKMDGQRSKSLADIKESMETPPGRWLKSPTTPVDPERQWNLTSPSEETLNEGEILEYTKSIEKLNSSLHFLQQEMQRLSLQQEMLMQMREQQAWVISPPQPSPQKQIRDFKPRQAGLSSAAAPFSSDSPRPTHPSPQSSTRKSASFSVKNQRTPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPSQVPIQTRSFVCFGDDGEPQKEPKQKEEIKKEPSECKGTLGPCDHNPGEKEIKPVESTVSEVLSQPITETVCVTPNEDQLSQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVSVEKLDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQAAKQKKQRPKSIHRDHIESPKTPIKGPPVSSLSLASLNTGDSESVHSGKRTPRSESVEGFLSPSRCGSRNGEKDWENASTTSSVASGTEYTGPKLYKEPSAKSNKHIIQNALAHCCLAGKVNEGQKKKILEEMEKSDANNFLILFRDSGCQFRSLYTYCPETEEINKLTGIGPKSITKKMIEGLYKYNSDRKQFSHIPAKTLSASVDAITIHSHLWQTKRPVTPKKLLPTKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Ubiquitination	TFIVPAIKPFDHYDF HEEECCCCCCCCCCH	41.56	-
242	Phosphorylation	ENLLKDGTDGCALAA HHHHCCCCCHHHHHH	39.08	22817900
361	Methylation	NAAKRNIRDSSSSSD HHHHHCCCCCCCCCC	41.11	-
363	Phosphorylation	AKRNIRDSSSSSDFS HHHCCCCCCCCCCCH	23.44	25521595
365	Phosphorylation	RNIRDSSSSSDFSSR HCCCCCCCCCCCHHC	37.50	30352176
389	Phosphorylation	ASGGIRRSSSMSYVD CCCCCCCCCCCCEEC	19.54	24925903
390	Phosphorylation	SGGIRRSSSMSYVDG CCCCCCCCCCCEECC	28.40	24925903
391	Phosphorylation	GGIRRSSSMSYVDGF CCCCCCCCCCEECCC	17.00	25521595
393	Phosphorylation	IRRSSSMSYVDGFIG CCCCCCCCEECCCCC	24.77	24925903
394	Phosphorylation	RRSSSMSYVDGFIGT CCCCCCCEECCCCCC	8.23	24925903
401	Phosphorylation	YVDGFIGTWPKEKRT EECCCCCCCCCHHCE	33.50	24925903
408	Phosphorylation	TWPKEKRTSVHGVSF CCCCHHCEEEEEEEE	46.28	29899451
409	Phosphorylation	WPKEKRTSVHGVSFD CCCHHCEEEEEEEEE	19.02	22324799
414	Phosphorylation	RTSVHGVSFDISFDK CEEEEEEEEEEEECC	23.07	23375375
418	Phosphorylation	HGVSFDISFDKEDSA EEEEEEEEECCCCCC	29.27	22817900
429	Phosphorylation	EDSAQSSTPNRGIIR CCCCCCCCCCCCCCE	29.81	27841257
437	Phosphorylation	PNRGIIRSVSNEGLT CCCCCCEEECCCCCE	21.35	25521595
439	Phosphorylation	RGIIRSVSNEGLTLN CCCCEEECCCCCEEC	30.34	25521595
444	Phosphorylation	SVSNEGLTLNNSRAS EECCCCCEECCCHHH	37.99	25619855
448	Phosphorylation	EGLTLNNSRASKHIR CCCEECCCHHHHHHH	28.31	25619855
451	Phosphorylation	TLNNSRASKHIRKNL EECCCHHHHHHHHCC	24.53	29899451
572	Phosphorylation	SNIKLNQSSPDNLTD CCCCCCCCCCCCCCC	42.64	25521595
573	Phosphorylation	NIKLNQSSPDNLTDT CCCCCCCCCCCCCCC	26.89	25521595
578	Phosphorylation	QSSPDNLTDTKGALS CCCCCCCCCCCCCCC	48.12	22324799
580	Phosphorylation	SPDNLTDTKGALSPI CCCCCCCCCCCCCCC	26.58	20415495
585	Phosphorylation	TDTKGALSPITDTTE CCCCCCCCCCCCCCC	17.45	25619855
588	Phosphorylation	KGALSPITDTTEVDT CCCCCCCCCCCCCCC	30.58	25619855
590	Phosphorylation	ALSPITDTTEVDTGI CCCCCCCCCCCCCCC	19.06	25619855
620	Phosphorylation	SLRDYTVSLDSDMDD CCCCEEEECCCCCHH	20.75	22817900
623	Phosphorylation	DYTVSLDSDMDDASK CEEEECCCCCHHHHH	39.88	25521595
647	Phosphorylation	SNPREALSPCPSTIS CCHHHHHCCCCCCCC	31.35	25521595
651	Phosphorylation	EALSPCPSTISTKSQ HHHCCCCCCCCCCCC	45.12	29899451
652	Phosphorylation	ALSPCPSTISTKSQP HHCCCCCCCCCCCCC	12.23	22817900
654	Phosphorylation	SPCPSTISTKSQPGS CCCCCCCCCCCCCCC	29.85	22817900
655	Phosphorylation	PCPSTISTKSQPGSS CCCCCCCCCCCCCCC	30.75	21082442
657	Phosphorylation	PSTISTKSQPGSSAS CCCCCCCCCCCCCCC	41.52	-
697	Phosphorylation	SGSSSQKTTPEGSEL CCCCCCCCCCCCCCC	39.69	19060867
711	Phosphorylation	LNIPHVVSWAQIPEE CCCCCEEEHHHCCHH	18.66	21183079
784	Phosphorylation	KKKGEGISPLREEAA ECCCCCCCHHHHHHC	28.83	26824392
816	Phosphorylation	QKMDGQRSKSLADIK HHCCCCCCCCHHHHH	20.78	28066266
818	Phosphorylation	MDGQRSKSLADIKES CCCCCCCCHHHHHHH	30.00	22324799
825	Phosphorylation	SLADIKESMETPPGR CHHHHHHHHCCCCCC	19.54	29176673
836	Phosphorylation	PPGRWLKSPTTPVDP CCCCCCCCCCCCCCH	25.88	25521595
838	Phosphorylation	GRWLKSPTTPVDPER CCCCCCCCCCCCHHH	51.31	23684622
839	Phosphorylation	RWLKSPTTPVDPERQ CCCCCCCCCCCHHHC	25.38	21082442
850	Phosphorylation	PERQWNLTSPSEETL HHHCCCCCCCCHHHC	35.06	23984901
851	Phosphorylation	ERQWNLTSPSEETLN HHCCCCCCCCHHHCC	29.60	20415495
853	Phosphorylation	QWNLTSPSEETLNEG CCCCCCCCHHHCCCC	48.08	20415495
856	Phosphorylation	LTSPSEETLNEGEIL CCCCCHHHCCCCCHH	30.72	23984901
905	Phosphorylation	EQQAWVISPPQPSPQ HHHCEEECCCCCCHH	22.40	25521595
910	Phosphorylation	VISPPQPSPQKQIRD EECCCCCCHHHHHCC	34.41	25521595
926	Phosphorylation	KPRQAGLSSAAAPFS CHHHCCCCCCCCCCC	19.60	29472430
927	Phosphorylation	PRQAGLSSAAAPFSS HHHCCCCCCCCCCCC	27.28	29472430
933	Phosphorylation	SSAAAPFSSDSPRPT CCCCCCCCCCCCCCC	31.98	28066266
934	Phosphorylation	SAAAPFSSDSPRPTH CCCCCCCCCCCCCCC	42.35	28066266
936	Phosphorylation	AAPFSSDSPRPTHPS CCCCCCCCCCCCCCC	25.42	28066266
940	Phosphorylation	SSDSPRPTHPSPQSS CCCCCCCCCCCCCCC	47.93	28066266
943	Phosphorylation	SPRPTHPSPQSSTRK CCCCCCCCCCCCCCC	28.15	19060867
946	Phosphorylation	PTHPSPQSSTRKSAS CCCCCCCCCCCCCCE	36.74	28066266
947	Phosphorylation	THPSPQSSTRKSASF CCCCCCCCCCCCCEE	27.30	28066266
948	Phosphorylation	HPSPQSSTRKSASFS CCCCCCCCCCCCEEE	47.57	28066266
953	Phosphorylation	SSTRKSASFSVKNQR CCCCCCCEEEECCCC	25.75	29176673
955	Phosphorylation	TRKSASFSVKNQRTP CCCCCEEEECCCCCC	29.68	29899451
970	Phosphorylation	RPNELKITPLNRTLT CCCCCEEECCCCCCC	21.82	22871156
975	Phosphorylation	KITPLNRTLTPPRSV EEECCCCCCCCCCCC	33.63	24759943
977	Phosphorylation	TPLNRTLTPPRSVDS ECCCCCCCCCCCCCC	30.54	26643407
981	Phosphorylation	RTLTPPRSVDSLPRL CCCCCCCCCCCCCCH	35.73	-
984	Phosphorylation	TPPRSVDSLPRLRRF CCCCCCCCCCCHHCC	37.81	25777480
992	Phosphorylation	LPRLRRFSPSQVPIQ CCCHHCCCCCCCCCC	23.10	25521595
994	Phosphorylation	RLRRFSPSQVPIQTR CHHCCCCCCCCCCCC	42.48	23684622
1000	Phosphorylation	PSQVPIQTRSFVCFG CCCCCCCCCEEEEEC	29.06	22705319
1104	Ubiquitination	EVSLSDLKPPEKADV EEEHHHCCCCCCCCC	64.61	-
1112	Phosphorylation	PPEKADVSVEKLDGE CCCCCCCCEEECCCC	25.71	25619855
1120	Phosphorylation	VEKLDGESDKEQFDD EEECCCCCCHHHCCC	60.56	25521595
1208	Phosphorylation	REFIRQEYMRRKQLK HHHHHHHHHHHHHHH	6.38	29514104
1222	Phosphorylation	KLMEDMDTVIKPRPQ HHHHCCHHHHCCCHH	19.93	26643407
1240	Phosphorylation	QKKQRPKSIHRDHIE HHHCCCCCCCHHHCC	26.72	25266776
1248	Phosphorylation	IHRDHIESPKTPIKG CCHHHCCCCCCCCCC	30.97	25521595
1251	Phosphorylation	DHIESPKTPIKGPPV HHCCCCCCCCCCCCC	33.36	25521595
1273	Phosphorylation	LNTGDSESVHSGKRT CCCCCCCCCCCCCCC	29.14	26060331
1276	Phosphorylation	GDSESVHSGKRTPRS CCCCCCCCCCCCCCC	43.80	29899451
1280	Phosphorylation	SVHSGKRTPRSESVE CCCCCCCCCCCCCCC	26.92	23984901
1283	Phosphorylation	SGKRTPRSESVEGFL CCCCCCCCCCCCCCC	35.11	24925903
1285	Phosphorylation	KRTPRSESVEGFLSP CCCCCCCCCCCCCCC	27.07	24925903
1291	Phosphorylation	ESVEGFLSPSRCGSR CCCCCCCCCCCCCCC	20.68	25521595
1293	Phosphorylation	VEGFLSPSRCGSRNG CCCCCCCCCCCCCCC	36.51	25521595
1308	Phosphorylation	EKDWENASTTSSVAS CCCHHHCCCCCCCCC	43.74	23375375
1309	Phosphorylation	KDWENASTTSSVASG CCHHHCCCCCCCCCC	28.43	23375375
1310	Phosphorylation	DWENASTTSSVASGT CHHHCCCCCCCCCCC	19.26	23375375
1311	Phosphorylation	WENASTTSSVASGTE HHHCCCCCCCCCCCC	23.93	23375375
1312	Phosphorylation	ENASTTSSVASGTEY HHCCCCCCCCCCCCC	21.43	23375375
1315	Phosphorylation	STTSSVASGTEYTGP CCCCCCCCCCCCCCC	44.06	25521595
1317	Phosphorylation	TSSVASGTEYTGPKL CCCCCCCCCCCCCCC	24.27	23375375
1407	Acetylation	IGPKSITKKMIEGLY CCCHHHHHHHHHHHH	38.38	19854219
1408	Acetylation	GPKSITKKMIEGLYK CCHHHHHHHHHHHHH	36.14	15609651
1452	Phosphorylation	WQTKRPVTPKKLLPT HCCCCCCCHHHHCCC	31.88	27149854

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAMP2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAMP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAMP2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CAMP2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1291, AND MASSSPECTROMETRY.
PubMed: 17114649

"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-573, AND MASSSPECTROMETRY.
PubMed: 15345747

"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1222, AND MASSSPECTROMETRY.
PubMed: 17203969