dbPTM

AT2B2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AT2B2_MOUSE
UniProt AC	Q9R0K7
Protein Name	Plasma membrane calcium-transporting ATPase 2
Gene Name	Atp2b2
Organism	Mus musculus (Mouse).
Sequence Length	1198
Subcellular Localization	Cell junction, synapse . Cell membrane Multi-pass membrane protein .
Protein Description	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. Plays a role in maintaining balance and hearing..
Protein Sequence	MGDMTNSDFYSKNQRNESSHGGEFGCTMEELRSLMELRGTEAVVKIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGESNEGCATAQGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQIKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKAKQQDGAAAMEMQPLKSAEGGDADDKKKANMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWLTECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINAKTLELLVNAIAINSAYTTKILPPEKEGALPRQVGNKTECGLLGFVLDLRQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTVIKMPDESFRMYSKGASEIVLKKCCKILSGAGEARVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLTLIFTLLFVGEKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTSRLKFLKEAGRLTQKEEIPEEELNEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDLEEDAALKQNSSPPSSLNKNNSAIDSGINLTTDTSKSATSSSPGSPIHSLETSL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MGDMTNSDFYSKNQ -CCCCCHHHHHCCCC	21.67	-
12	Ubiquitination	TNSDFYSKNQRNESS CHHHHHCCCCCCCCC	45.80	-
18	Phosphorylation	SKNQRNESSHGGEFG CCCCCCCCCCCCCCC	31.05	25521595
19	Phosphorylation	KNQRNESSHGGEFGC CCCCCCCCCCCCCCC	21.70	22324799
45	Ubiquitination	RGTEAVVKIKETYGD HCCEEEEEEEHHHCC	41.27	-
47	Ubiquitination	TEAVVKIKETYGDTE CEEEEEEEHHHCCHH	37.98	-
49	Phosphorylation	AVVKIKETYGDTEAI EEEEEEHHHCCHHHH	28.00	25367039
50	Phosphorylation	VVKIKETYGDTEAIC EEEEEHHHCCHHHHH	17.69	25367039
53	Phosphorylation	IKETYGDTEAICRRL EEHHHCCHHHHHHHH	23.97	25367039
61	Ubiquitination	EAICRRLKTSPVEGL HHHHHHHCCCCCCCC	45.18	-
62	Phosphorylation	AICRRLKTSPVEGLP HHHHHHCCCCCCCCC	42.74	29899451
63	Phosphorylation	ICRRLKTSPVEGLPG HHHHHCCCCCCCCCC	25.92	29899451
77	Ubiquitination	GTAPDLEKRKQIFGQ CCCCCHHHHHHHHCC	72.67	-
191	Ubiquitination	SRIEQEQKFTVVRAG HHHHHHCCEEEEECC	42.10	-
218	Phosphorylation	GDIAQIKYGDLLPAD CCHHHCCCCCEECCC	19.94	29899451
239	Phosphorylation	NDLKIDESSLTGESD CCEEECHHHCCCCCH	27.22	25521595
240	Phosphorylation	DLKIDESSLTGESDQ CEEECHHHCCCCCHH	28.09	20415495
242	Phosphorylation	KIDESSLTGESDQVR EECHHHCCCCCHHHH	40.63	29899451
245	Phosphorylation	ESSLTGESDQVRKSV HHHCCCCCHHHHHHC	34.39	29899451
254	Ubiquitination	QVRKSVDKDPMLLSG HHHHHCCCCCCCCCC	62.67	-
262	Phosphorylation	DPMLLSGTHVMEGSG CCCCCCCCEEECCCC	14.12	-
268	Phosphorylation	GTHVMEGSGRMVVTA CCEEECCCCCEEEEE	15.21	-
282	Phosphorylation	AVGVNSQTGIIFTLL EEEECCCCCEEEEEE	30.12	28059163
304	Ubiquitination	EKKDKKAKQQDGAAA HHHHHHHHHHCCCHH	58.32	-
318	Ubiquitination	AMEMQPLKSAEGGDA HHHCCCCCCCCCCCC	55.06	-
319	Phosphorylation	MEMQPLKSAEGGDAD HHCCCCCCCCCCCCC	38.96	29899451
431	Ubiquitination	YSVKKMMKDNNLVRH HHHHHHHCCCCHHHH	54.53	-
456	Phosphorylation	TAICSDKTGTLTTNR EEEECCCCCCEECCC	40.15	25521595
458	Phosphorylation	ICSDKTGTLTTNRMT EECCCCCCEECCCEE	26.60	22324799
460	Phosphorylation	SDKTGTLTTNRMTVV CCCCCCEECCCEEEE	23.12	22324799
477	Ubiquitination	YVGDVHYKEIPDPSS EECCEECCCCCCHHH	34.00	-
512	Ubiquitination	TKILPPEKEGALPRQ CCCCCCCCCCCCCCC	68.19	-
526	S-nitrosylation	QVGNKTECGLLGFVL CCCCCCCCCHHHHHH	5.87	22588120
550	Ubiquitination	RSQMPEEKLYKVYTF HHCCCHHHHHEEEEH	56.29	-
553	Ubiquitination	MPEEKLYKVYTFNSV CCHHHHHEEEEHHHH	38.92	-
555	Phosphorylation	EEKLYKVYTFNSVRK HHHHHEEEEHHHHCH	11.06	25195567
559	Phosphorylation	YKVYTFNSVRKSMST HEEEEHHHHCHHHCC	21.07	29899451
569	Ubiquitination	KSMSTVIKMPDESFR HHHCCEEECCCHHHC	39.79	-
583	Phosphorylation	RMYSKGASEIVLKKC CHHCCCCHHHHHHHH	36.20	28464351
588	Acetylation	GASEIVLKKCCKILS CCHHHHHHHHHHHHC	32.63	19860257
613	Ubiquitination	RDRDEMVKKVIEPMA CCHHHHHHHHHHHHH	39.76	-
614	Ubiquitination	DRDEMVKKVIEPMAC CHHHHHHHHHHHHHC	36.71	-
681	Phosphorylation	KCQRAGITVRMVTGD HHHHCCCEEEEECCC	10.92	28059163
692	Phosphorylation	VTGDNINTARAIAIK ECCCCHHHHHHHHHH	17.45	28059163
699	Ubiquitination	TARAIAIKCGIIHPG HHHHHHHHCCEECCC	19.86	-
715	Ubiquitination	DFLCLEGKEFNRRIR CEEEECCHHHHHHHH	50.16	-
725	Ubiquitination	NRRIRNEKGEIEQER HHHHHCCCCCCCHHH	66.45	-
735	Ubiquitination	IEQERIDKIWPKLRV CCHHHHHHHHHHHHH	44.28	-
747	Phosphorylation	LRVLARSSPTDKHTL HHHHHCCCCCCHHHH	26.68	-
777	Phosphorylation	VAVTGDGTNDGPALK EEEECCCCCCCHHHH	34.57	20415495
784	Acetylation	TNDGPALKKADVGFA CCCCHHHHHCCCEEE	48.28	19847399
784	Ubiquitination	TNDGPALKKADVGFA CCCCHHHHHCCCEEE	48.28	-
785	Ubiquitination	NDGPALKKADVGFAM CCCHHHHHCCCEEEH	51.15	-
804	Phosphorylation	TDVAKEASDIILTDD CHHHHHHHHEEECCC	30.36	29899451
814	Phosphorylation	ILTDDNFSSIVKAVM EECCCCHHHHHHHHH	25.96	20415495
815	Phosphorylation	LTDDNFSSIVKAVMW ECCCCHHHHHHHHHC	27.54	20415495
1056	Ubiquitination	EAGRLTQKEEIPEEE HHCCCCCCHHCCHHH	52.67	-
1087	Methylation	RGQILWFRGLNRIQT HCCEEEEECCCHHHH	36.79	-
1087	Dimethylation	RGQILWFRGLNRIQT HCCEEEEECCCHHHH	36.79	-
1094	Phosphorylation	RGLNRIQTQIRVVKA ECCCHHHHHHHHHHH	24.48	29899451
1104	Phosphorylation	RVVKAFRSSLYEGLE HHHHHHHHHHHHCCC	20.45	25521595
1105	Phosphorylation	VVKAFRSSLYEGLEK HHHHHHHHHHHCCCC	30.62	27742792
1107	Phosphorylation	KAFRSSLYEGLEKPE HHHHHHHHHCCCCCC	15.20	25159016
1112	Ubiquitination	SLYEGLEKPESRTSI HHHHCCCCCCCCCCH	60.16	-
1112	Acetylation	SLYEGLEKPESRTSI HHHHCCCCCCCCCCH	60.16	7632155
1115	Phosphorylation	EGLEKPESRTSIHNF HCCCCCCCCCCHHHH	49.76	25521595
1117	Phosphorylation	LEKPESRTSIHNFMA CCCCCCCCCHHHHCC	41.11	25521595
1118	Phosphorylation	EKPESRTSIHNFMAH CCCCCCCCHHHHCCC	22.27	25521595
1133	Phosphorylation	PEFRIEDSQPHIPLI CCEECCCCCCCCCCC	32.59	25521595
1143	Phosphorylation	HIPLIDDTDLEEDAA CCCCCCCCCHHHHHH	38.44	25521595
1155	Phosphorylation	DAALKQNSSPPSSLN HHHHHCCCCCCHHHC	41.55	25521595
1156	Phosphorylation	AALKQNSSPPSSLNK HHHHCCCCCCHHHCC	48.67	25521595
1159	Phosphorylation	KQNSSPPSSLNKNNS HCCCCCCHHHCCCCC	51.33	25521595
1160	Phosphorylation	QNSSPPSSLNKNNSA CCCCCCHHHCCCCCC	41.56	25521595
1166	Phosphorylation	SSLNKNNSAIDSGIN HHHCCCCCCCCCCCC	35.67	20415495
1170	Phosphorylation	KNNSAIDSGINLTTD CCCCCCCCCCCCCCC	35.14	25521595
1179	Phosphorylation	INLTTDTSKSATSSS CCCCCCCCCCCCCCC	27.67	25521595
1181	Phosphorylation	LTTDTSKSATSSSPG CCCCCCCCCCCCCCC	36.22	25619855
1183	Phosphorylation	TDTSKSATSSSPGSP CCCCCCCCCCCCCCC	35.91	25619855
1184	Phosphorylation	DTSKSATSSSPGSPI CCCCCCCCCCCCCCC	28.65	25619855
1185	Phosphorylation	TSKSATSSSPGSPIH CCCCCCCCCCCCCCC	35.88	24925903
1186	Phosphorylation	SKSATSSSPGSPIHS CCCCCCCCCCCCCCC	32.80	24925903
1189	Phosphorylation	ATSSSPGSPIHSLET CCCCCCCCCCCCCCC	24.86	25521595
1193	Phosphorylation	SPGSPIHSLETSL-- CCCCCCCCCCCCC--	28.72	25521595
1196	Phosphorylation	SPIHSLETSL----- CCCCCCCCCC-----	40.39	25521595
1197	Phosphorylation	PIHSLETSL------ CCCCCCCCC------	23.78	24925903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1094	T	Phosphorylation	Kinase	PKC	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AT2B2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AT2B2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of AT2B2_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AT2B2_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1197, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1189 AND THR-1196, ANDMASS SPECTROMETRY.	17114649 [Abstract]