| UniProt ID | PFKAM_MOUSE | |
|---|---|---|
| UniProt AC | P47857 | |
| Protein Name | ATP-dependent 6-phosphofructokinase, muscle type {ECO:0000255|HAMAP-Rule:MF_03184} | |
| Gene Name | Pfkm | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 780 | |
| Subcellular Localization |
Cytoplasm . Isoform 2: Cell projection, cilium, flagellum . Principal piece region of the sperm flagellum. Isoform 3: Cell projection, cilium, flagellum . Principal piece region of the sperm flagellum. |
|
| Protein Description | Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.. | |
| Protein Sequence | MTHEEHHAAKTLGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGEHIREATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLNDLQKDGKITAEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIVEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKRFDEAIKLRGRSFMNNWEVYKLLAHVRPPVSKGGLHTVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKNLEQISANITKFNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSIGADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQVNVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVTELKDQTDFEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHISRKRSGEAAV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MTHEEHHAA ------CCHHHHHHH | 22210690 | ||
| 2 | Acetylation | ------MTHEEHHAA ------CCHHHHHHH | - | ||
| 107 | Ubiquitination | RAAHNLVKRGITNLC HHHHHHHHCCCCEEE | - | ||
| 114 | S-nitrosocysteine | KRGITNLCVIGGDGS HCCCCEEEEECCCCC | - | ||
| 133 | Phosphorylation | DTFRSEWSDLLNDLQ HHHHHHHHHHHHHHH | - | ||
| 141 | Ubiquitination | DLLNDLQKDGKITAE HHHHHHHHCCCCCHH | 22790023 | ||
| 170 | S-nitrosocysteine | GSIDNDFCGTDMTIG CCCCCCCCCCCCCCC | - | ||
| 194 | Phosphorylation | EIVDAITTTAQSHQR HHHHHHHHHCHHHHH | 28464351 | ||
| 198 | Phosphorylation | AITTTAQSHQRTFVL HHHHHCHHHHHEHHH | 29899451 | ||
| 304 | Phosphorylation | GHVQRGGTPSAFDRI EEHHHCCCHHHHHHH | 24899341 | ||
| 306 | Phosphorylation | VQRGGTPSAFDRILG HHHCCCHHHHHHHHH | 23737553 | ||
| 334 | S-nitrosocysteine | GTPDTPACVVSLSGN CCCCCCEEEEECCCC | - | ||
| 351 | S-nitrosocysteine | VRLPLMECVQVTKDV EEEEHHHHHHHCHHH | - | ||
| 372 | Ubiquitination | KRFDEAIKLRGRSFM HHHHHHHHHHCCHHH | 22790023 | ||
| 377 | Phosphorylation | AIKLRGRSFMNNWEV HHHHHCCHHHCCHHH | 25521595 | ||
| 476 | Malonylation | TKRTLPKKNLEQISA CCCCCCCCCHHHHHH | 26320211 | ||
| 486 | Phosphorylation | EQISANITKFNIQGL HHHHHCCEEEEEEEE | 28464351 | ||
| 530 | O-linked_Glycosylation | VVIPATVSNNVPGSD EEEEEECCCCCCCCC | - | ||
| 557 | Other | CTTCDRIKQSAAGTK HHHHHHHHHCCCCCC | - | ||
| 667 | Phosphorylation | GHMQQGGSPTPFDRN HCHHCCCCCCCCCHH | 25521595 | ||
| 669 | Phosphorylation | MQQGGSPTPFDRNFA HHCCCCCCCCCHHHH | 25521595 | ||
| 677 | Phosphorylation | PFDRNFATKMGAKAM CCCHHHHHHHHHHHH | 22324799 | ||
| 678 | Malonylation | FDRNFATKMGAKAMN CCHHHHHHHHHHHHH | 26320211 | ||
| 678 | Phosphoglycerylation | FDRNFATKMGAKAMN CCHHHHHHHHHHHHH | - | ||
| 678 | Ubiquitination | FDRNFATKMGAKAMN CCHHHHHHHHHHHHH | 27667366 | ||
| 682 | Malonylation | FATKMGAKAMNWMSG HHHHHHHHHHHHHCC | 26320211 | ||
| 682 | Ubiquitination | FATKMGAKAMNWMSG HHHHHHHHHHHHHCC | 27667366 | ||
| 692 | Ubiquitination | NWMSGKIKESYRNGR HHHCCCHHHHHHCCC | 27667366 | ||
| 704 | Phosphorylation | NGRIFANTPDSGCVL CCCCEECCCCCCCCC | 28464351 | ||
| 709 | S-nitrosocysteine | ANTPDSGCVLGMRKR ECCCCCCCCCCCCCE | - | ||
| 724 | Phosphorylation | ALVFQPVTELKDQTD EEEEEEECCCCCCCC | 28464351 | ||
| 748 | Ubiquitination | WWLKLRPILKILAKY HHHHHHHHHHHHHHC | 27667366 | ||
| 752 | Ubiquitination | LRPILKILAKYEIDL HHHHHHHHHHCCCCC | 27667366 | ||
| 762 | Ubiquitination | YEIDLDTSDHAHLEH CCCCCCCCCCHHHHH | 27667366 | ||
| 762 | Phosphorylation | YEIDLDTSDHAHLEH CCCCCCCCCCHHHHH | 27841257 | ||
| 771 | Phosphorylation | HAHLEHISRKRSGEA CHHHHHHHHCCCCCC | 28464351 | ||
| 775 | Phosphorylation | EHISRKRSGEAAV-- HHHHHCCCCCCCC-- | 25521595 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PFKAM_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PFKAM_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PFKAM_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PFKAM_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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