LDB1_MOUSE - dbPTM
LDB1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LDB1_MOUSE
UniProt AC P70662
Protein Name LIM domain-binding protein 1
Gene Name Ldb1
Organism Mus musculus (Mouse).
Sequence Length 411
Subcellular Localization Nucleus . Colocalizes with SLK at leading edges (PubMed:19675209).
Protein Description Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state..
Protein Sequence MSVGCACPGCSSKSFKLYSPKEPPNGNAFPPFHPGTMLDRDVGPTPMYPPTYLEPGIGRHTPYGNQTDYRIFELNKRLQNWTEECDNLWWDAFTTEFFEDDAMLTITFCLEDGPKRYTIGRTLIPRYFRSIFEGGATELYYVLKHPKEAFHSNFVSLDCDQGSMVTQHGKPMFTQVCVEGRLYLEFMFDDMMRIKTWHFSIRQHRELIPRSILAMHAQDPQMLDQLSKNITRCGLSNSTLNYLRLCVILEPMQELMSRHKTYSLSPRDCLKTCLFQKWQRMVAPPAEPARQQPSKRRKRKMSGGSTMSSGGGNTNNSNSKKKSPASTFALSSQVPDVMVVGEPTLMGGEFGDEDERLITRLENTQFDAANGIDDEDSFNNSPALGANSPWNSKPPSSQESKSENPTSQASQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSVGCACPG
------CCCCCCCCC		27.50-
2Phosphorylation------MSVGCACPG
------CCCCCCCCC		27.5030482847
18PhosphorylationSSKSFKLYSPKEPPN
CCCCEEEECCCCCCC		24.4222817900
19PhosphorylationSKSFKLYSPKEPPNG
CCCEEEECCCCCCCC		39.6722817900
45PhosphorylationLDRDVGPTPMYPPTY
CCCCCCCCCCCCCCC		18.1125777480
48PhosphorylationDVGPTPMYPPTYLEP
CCCCCCCCCCCCCCC		13.7825777480
51PhosphorylationPTPMYPPTYLEPGIG
CCCCCCCCCCCCCCC		35.9122817900
52PhosphorylationTPMYPPTYLEPGIGR
CCCCCCCCCCCCCCC		18.1625777480
61PhosphorylationEPGIGRHTPYGNQTD
CCCCCCCCCCCCHHH		19.4923684622
63PhosphorylationGIGRHTPYGNQTDYR
CCCCCCCCCCHHHHH		29.8421183079
67PhosphorylationHTPYGNQTDYRIFEL
CCCCCCHHHHHHHHH		38.7125777480
69PhosphorylationPYGNQTDYRIFELNK
CCCCHHHHHHHHHHH		14.7025777480
127PhosphorylationGRTLIPRYFRSIFEG
CCCHHHHHHHHHHCC		9.6721149613
130PhosphorylationLIPRYFRSIFEGGAT
HHHHHHHHHHCCCCE		23.0221149613
195AcetylationFDDMMRIKTWHFSIR
HHHHHHHHHHCEEHH		34.8922826441
261PhosphorylationELMSRHKTYSLSPRD
HHHHHCCCCCCCHHH		16.5325777480
262PhosphorylationLMSRHKTYSLSPRDC
HHHHCCCCCCCHHHH		16.6525777480
263PhosphorylationMSRHKTYSLSPRDCL
HHHCCCCCCCHHHHH		27.8328066266
265PhosphorylationRHKTYSLSPRDCLKT
HCCCCCCCHHHHHHH		16.3722817900
277UbiquitinationLKTCLFQKWQRMVAP
HHHHHHHHHHHHCCC		37.6522790023
302PhosphorylationKRRKRKMSGGSTMSS
HHCCCCCCCCCCCCC		42.9325521595
305PhosphorylationKRKMSGGSTMSSGGG
CCCCCCCCCCCCCCC		25.1823684622
306PhosphorylationRKMSGGSTMSSGGGN
CCCCCCCCCCCCCCC		25.0927087446
308PhosphorylationMSGGSTMSSGGGNTN
CCCCCCCCCCCCCCC		26.3927087446
309PhosphorylationSGGSTMSSGGGNTNN
CCCCCCCCCCCCCCC		30.5425521595
314PhosphorylationMSSGGGNTNNSNSKK
CCCCCCCCCCCCCCC		38.7729899451
323PhosphorylationNSNSKKKSPASTFAL
CCCCCCCCCHHHHHH		34.2822817900
326PhosphorylationSKKKSPASTFALSSQ
CCCCCCHHHHHHCCC		27.6919060867
327PhosphorylationKKKSPASTFALSSQV
CCCCCHHHHHHCCCC		18.2921082442
331PhosphorylationPASTFALSSQVPDVM
CHHHHHHCCCCCCEE		18.4625338131
332PhosphorylationASTFALSSQVPDVMV
HHHHHHCCCCCCEEE		35.73-
381PhosphorylationDEDSFNNSPALGANS
CHHHCCCCCCCCCCC		16.8029899451
388PhosphorylationSPALGANSPWNSKPP
CCCCCCCCCCCCCCC		30.6629514104
392PhosphorylationGANSPWNSKPPSSQE
CCCCCCCCCCCCCCC		42.5425338131
393AcetylationANSPWNSKPPSSQES
CCCCCCCCCCCCCCC		58.7023236377
396PhosphorylationPWNSKPPSSQESKSE
CCCCCCCCCCCCCCC		53.8625338131
410PhosphorylationENPTSQASQ------
CCCCCCCCC------		28.8729899451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseRlimQ9WTV7
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LDB1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LDB1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LHX1_MOUSELhx1physical
20211142
LHX2_MOUSELhx2physical
20211142
LHX4_MOUSELhx4physical
20211142
LHX5_MOUSELhx5physical
20211142
LHX9_MOUSELhx9physical
20211142
RBTN2_MOUSELmo2physical
20211142
LMO4_MOUSELmo4physical
20211142
LMX1B_MOUSELmx1bphysical
20211142
SSBP2_MOUSESsbp2physical
20211142
ZN593_MOUSEZfp593physical
20211142
PYGO1_MOUSEPygo1physical
20211142
SSBP3_MOUSESsbp3physical
20211142
ISL2_MOUSEIsl2physical
20211142
CSDC2_MOUSECsdc2physical
20211142
LMO3_MOUSELmo3physical
20211142
RBTN1_MOUSELmo1physical
20211142
LMX1A_MOUSELmx1aphysical
20211142
TADBP_MOUSETardbpphysical
20211142
PITX2_MOUSEPitx2physical
12464179
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LDB1_MOUSE

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Related Literatures of Post-Translational Modification

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