LHX4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LHX4_MOUSE
• UniProt AC: P53776
• Protein Name: LIM/homeobox protein Lhx4
• Gene Name: Lhx4
• Organism: Mus musculus (Mouse).
• Sequence Length: 390
• Subcellular Localization: Nucleus .
• Protein Description: May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA (By similarity)..
• Protein Sequence: MMQSAAVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGGSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVTGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQTLRAMAGGPTSDLSTGSSVGYPDFPTSPASWLDEMDHPPF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Ubiquitination	ILDKFILKVLDRHWH HHHHHHHHHHHHHCH	35.62	22790023
70	Phosphorylation	QLADRCFSRAGSVYC HHHHHHHHCCCCEEE	25.50	26643407
74	Phosphorylation	RCFSRAGSVYCKEDF HHHHCCCCEEECHHH	14.66	26643407
234	Phosphorylation	FYKSVKRSRGGSKQE HHHHHHHHCCCCHHH	29.56	-
238	Phosphorylation	VKRSRGGSKQEKESS HHHHCCCCHHHHHCC	33.71	-
244	Phosphorylation	GSKQEKESSAEDCGV CCHHHHHCCHHHHCC	46.01	28066266
245	Phosphorylation	SKQEKESSAEDCGVS CHHHHHCCHHHHCCC	36.45	28066266
252	Phosphorylation	SAEDCGVSDSELSFR CHHHHCCCHHHHCCC	22.24	28066266
254	Phosphorylation	EDCGVSDSELSFRED HHHCCCHHHHCCCHH	32.69	28066266
257	Phosphorylation	GVSDSELSFREDQIL CCCHHHHCCCHHHHH	20.43	28066266
299	Phosphorylation	MDGTGQSYQDLRDGS ECCCCCCHHHCCCCC	9.73	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LHX4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LHX4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LHX4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ISL2_MOUSE	Isl2	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.