dbPTM

PYGO1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PYGO1_MOUSE
UniProt AC	Q9D0P5
Protein Name	Pygopus homolog 1
Gene Name	Pygo1
Organism	Mus musculus (Mouse).
Sequence Length	417
Subcellular Localization	Nucleus .
Protein Description	Involved in signal transduction through the Wnt pathway..
Protein Sequence	MSAEQDKEPIALKRVRGGDSGLDGLGGPNIQLGSPDKKKRKANTQGSSFPPLSEYAPPPNPNSDHLVAANPFDDSYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCGPYSLRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSNFGNPPYNNVLTQDINMPGQHFRQGSAENFSQIPPQNVGQVSNPDLASNFAPGNNSNFTSPLETNHSFIPPPNAFGQAKAPLPKQDFTQGATKTPNQNSSTHPPHLNMEDPVNQSNVELKNVNRNNVVQENSRSGSAEATNNHANGTQNKPRQPRGAADLCTPDKSRKFSLLPSRHGHSSSDPVYPCGICTNEVNDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTREAFGPPAVGGDA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Acetylation	-MSAEQDKEPIALKR -CCHHHCCCCCCCEE	66.15	23236377
13	Acetylation	DKEPIALKRVRGGDS CCCCCCCEECCCCCC	39.56	23236377
34	Phosphorylation	GPNIQLGSPDKKKRK CCCCCCCCCCHHHCC	38.22	27180971
290	Phosphorylation	QENSRSGSAEATNNH CCCCCCCCCCCCCCC	24.96	23684622
294	Phosphorylation	RSGSAEATNNHANGT CCCCCCCCCCCCCCC	28.23	-
301	Phosphorylation	TNNHANGTQNKPRQP CCCCCCCCCCCCCCC	28.86	-
404	Phosphorylation	KDVQLMRTREAFGPP CCHHHHHHHHHHCCC	20.92	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PYGO1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PYGO1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PYGO1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CERS2_MOUSE	Cers2	physical	20211142
ISL2_MOUSE	Isl2	physical	20211142

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PYGO1_MOUSE

Related Literatures of Post-Translational Modification