FOXO_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FOXO_CAEEL
• UniProt AC: O16850
• Protein Name: Forkhead box protein O {ECO:0000305}
• Gene Name: daf-16 {ECO:0000312|WormBase:R13H8.1h}
• Organism: Caenorhabditis elegans.
• Sequence Length: 541
• Subcellular Localization: Nucleus . Cytoplasm . Shuttles between cytoplasm and nucleus (PubMed:11381260, PubMed:17894411). Nuclear translocation is inhibited by phosphorylation by AKT proteins (PubMed:11381260, PubMed:11747825, PubMed:21531333). Association with ftt-2 sequest
• Protein Description: Forkhead-type transcription factor. [PubMed: 9360933 Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region]
• Protein Sequence: MQLEQKSSLHCSKCRNFLQKFSQDMQAWNCRELDSPLPSDITLHNLEPARPDSGMSFSTDFDDDFFNLDLHQQERSASFGGVTQYSQQFLREKCSFSPYFHTSLETVDSGRTSLYGSNEQCGQLGGASSNGSTAMLHTPDGSNSHQTSFPSDFRMSESPDDTVSGKKTTTRRNAWGNMSYAELITTAIMASPEKRLTLAQVYEWMVQNVPYFRDKGDSNSSAGWKNSIRHNLSLHSRFMRIQNEGAGKSSWWVINPDAKPGRNPRRTRERSNTIETTTKAQLEKSRRGAKKRIKERALMGSLHSTLNGNSIAGSIQTISHDLYDDDSMQGAFDNVPSSFRPRTQSNLSIPGSSSRVSPAIGSDIYDDLEFPSWVGESVPAIPSDIVDRTDQMRIDATTHIGGVQIKQESKPIKTEPIAPPPSYHELNSVRGSCAQNPLLRNPIVPSTNFKPMPLPGAYGNYQNGGITPINWLSTSNSSPLPGIQSCGIVAAQHTVASSSALPIDLENLTLPDQPLMDTMDVDALIRHELSQAGGQHIHFDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	Phosphorylation	DLHQQERSASFGGVT CHHHHHHHHHCCCCH	27.75	19060867
78	Phosphorylation	HQQERSASFGGVTQY HHHHHHHHCCCCHHH	26.18	28854356
227	Phosphorylation	SSAGWKNSIRHNLSL CCHHHHHHHHHHHHH	19.78	16751106
271	Phosphorylation	PRRTRERSNTIETTT CCCCCHHCCCCCHHH	33.31	19530675
273	Phosphorylation	RTRERSNTIETTTKA CCCHHCCCCCHHHHH	22.80	11381260
319	Phosphorylation	AGSIQTISHDLYDDD CCEEEEECCCCCCCC	17.84	9353126
343	Phosphorylation	PSSFRPRTQSNLSIP CHHCCCCCCCCCCCC	38.75	18806794
345	Phosphorylation	SFRPRTQSNLSIPGS HCCCCCCCCCCCCCC	38.84	11381260
348	Phosphorylation	PRTQSNLSIPGSSSR CCCCCCCCCCCCCCC	30.87	19060867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
319	S	Phosphorylation	Kinase	CAMK2	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FOXO_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FOXO_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BAR1_CAEEL	bar-1	physical	15905404
RLE1_CAEEL	rle-1	physical	17276341

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.