MADD_MOUSE - dbPTM
MADD_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MADD_MOUSE
UniProt AC Q80U28
Protein Name MAP kinase-activating death domain protein
Gene Name Madd {ECO:0000312|MGI:MGI:2444672}
Organism Mus musculus (Mouse).
Sequence Length 1577
Subcellular Localization Membrane . Cytoplasm.
Protein Description Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis)..
Protein Sequence MVQKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHPEFPLPPDVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRMPKEKVEGGAGPRGKEGAHTSGASEEAATGSSESGSTLQPPSADSTPDINQSPWGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLQDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQQALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPSNYAFQRIHNNTFDPALIGDKPKWYAHQLQPIHYRVYDGNSQLAEALSVPPERDSDSDPTEDSGSDSQDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDASEVEIDELQPQKEGEEPGPDSENSQENPPLRSSSSTTASSSPSTVVHSAHSEAADSTEMGDKATAGISKPLPPVPPSICKSTVDRRQTETGEGSVCQRTYDNPYFEPQYGFPPEEDEEEQGESYTPRFSQHVSGSRAQKLLRPNSLKLASDSDAESDSRASSPNSTVSNNSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKTTPFPSLKVFGLNTLMEIVTEAGPGSGEGNRRALVDQKSSVIKHSPTVKREPSSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRAVQSEDDARQDVIQDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTENVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFVASVELWNKHQEVKKQKALEKQRPEGIKPVFDLGETEEKKSQMSADSGVSLTSASQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGADSDLSSNAGDGPGGEGSAHLASSRATLSDSEIETNSATSAIFGKAHSLKPKEKPAGSPIRSSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSLSKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQVNEVLDQLNSLNGRDLSIRSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHNQFLKLKKW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
23PhosphorylationIVGARHPSSDSVAQT
EECCCCCCCCCCCCC		40.4229899451
26PhosphorylationARHPSSDSVAQTPEL
CCCCCCCCCCCCHHH		22.6929899451
30PhosphorylationSSDSVAQTPELLRRY
CCCCCCCCHHHHHCC		14.70-
155PhosphorylationSTPDINQSPWGKRRA
CCCCCCCCCCCHHHH		20.3820531401
227PhosphorylationDTMWRIFTGSLLVEE
HHHHHHHHCCHHHCC		24.4022324799
229PhosphorylationMWRIFTGSLLVEEKS
HHHHHHCCHHHCCHH		18.5722324799
256PhosphorylationWIYRLLRSPVPVSGQ
HHHHHHCCCCCCCCC		30.1630482847
261PhosphorylationLRSPVPVSGQKRVDI
HCCCCCCCCCCCEEE		29.4530482847
466PhosphorylationRPSNDLQSTPSTEFN
CCCCCCCCCCCCCCC		49.9729899451
467PhosphorylationPSNDLQSTPSTEFNP
CCCCCCCCCCCCCCC		14.3229899451
470PhosphorylationDLQSTPSTEFNPLIY
CCCCCCCCCCCCCCC		45.88-
540UbiquitinationRQTPFAEKLARTQAV
CCCCHHHHHHHCHHH		43.98-
688PhosphorylationGEEPGPDSENSQENP
CCCCCCCCCCCCCCC		41.64-
691PhosphorylationPGPDSENSQENPPLR
CCCCCCCCCCCCCCC		34.52-
699PhosphorylationQENPPLRSSSSTTAS
CCCCCCCCCCCCCCC		42.1026643407
700PhosphorylationENPPLRSSSSTTASS
CCCCCCCCCCCCCCC		23.1326643407
701PhosphorylationNPPLRSSSSTTASSS
CCCCCCCCCCCCCCC		32.7126643407
702PhosphorylationPPLRSSSSTTASSSP
CCCCCCCCCCCCCCC		31.5526643407
703PhosphorylationPLRSSSSTTASSSPS
CCCCCCCCCCCCCCC		28.4726643407
703 (in isoform 11)Phosphorylation-28.4722871156
703 (in isoform 7)Phosphorylation-28.4722871156
704PhosphorylationLRSSSSTTASSSPST
CCCCCCCCCCCCCCC		26.8726643407
706PhosphorylationSSSSTTASSSPSTVV
CCCCCCCCCCCCCEE		29.2926643407
707PhosphorylationSSSTTASSSPSTVVH
CCCCCCCCCCCCEEE		43.7524925903
708PhosphorylationSSTTASSSPSTVVHS
CCCCCCCCCCCEEEE		22.0024925903
708 (in isoform 11)Phosphorylation-22.0022871156
708 (in isoform 7)Phosphorylation-22.0022871156
710PhosphorylationTTASSSPSTVVHSAH
CCCCCCCCCEEEECC		35.4624925903
710 (in isoform 11)Phosphorylation-35.4622871156
710 (in isoform 7)Phosphorylation-35.4622871156
711PhosphorylationTASSSPSTVVHSAHS
CCCCCCCCEEEECCC		29.9024925903
715PhosphorylationSPSTVVHSAHSEAAD
CCCCEEEECCCCCCC		18.9629899451
748PhosphorylationVPPSICKSTVDRRQT
CCHHHCCCCCCCCCC		29.2929899451
755PhosphorylationSTVDRRQTETGEGSV
CCCCCCCCCCCCCCC		33.4324759943
757PhosphorylationVDRRQTETGEGSVCQ
CCCCCCCCCCCCCCC		43.8724759943
800PhosphorylationPRFSQHVSGSRAQKL
CCHHHHCCCHHHHHH		29.0028066266
802PhosphorylationFSQHVSGSRAQKLLR
HHHHCCCHHHHHHHC		19.5528066266
812PhosphorylationQKLLRPNSLKLASDS
HHHHCCCCCEECCCC		29.5725521595
817PhosphorylationPNSLKLASDSDAESD
CCCCEECCCCCCCCC		48.3525521595
819PhosphorylationSLKLASDSDAESDSR
CCEECCCCCCCCCCC		35.9025521595
823PhosphorylationASDSDAESDSRASSP
CCCCCCCCCCCCCCC		42.4825521595
825PhosphorylationDSDAESDSRASSPNS
CCCCCCCCCCCCCCC		38.7428833060
828PhosphorylationAESDSRASSPNSTVS
CCCCCCCCCCCCCCC		45.2626643407
829PhosphorylationESDSRASSPNSTVSN
CCCCCCCCCCCCCCC		27.4126643407
832PhosphorylationSRASSPNSTVSNNST
CCCCCCCCCCCCCCC		33.3026643407
833PhosphorylationRASSPNSTVSNNSTE
CCCCCCCCCCCCCCC		34.2925293948
835PhosphorylationSSPNSTVSNNSTEGF
CCCCCCCCCCCCCCC		30.3125293948
838PhosphorylationNSTVSNNSTEGFGGI
CCCCCCCCCCCCCHH		31.8926643407
839PhosphorylationSTVSNNSTEGFGGIM
CCCCCCCCCCCCHHH		42.1025293948
856 (in isoform 10)Phosphorylation-24.3727841257
856 (in isoform 12)Phosphorylation-24.3727841257
856 (in isoform 5)Phosphorylation-24.3727841257
856 (in isoform 6)Phosphorylation-24.3727841257
856 (in isoform 9)Phosphorylation-24.3727841257
857PhosphorylationSSLYRNHSTSFSLSN
HHHHHCCCCCCEECC		29.3325266776
858PhosphorylationSLYRNHSTSFSLSNL
HHHHCCCCCCEECCC		26.6625266776
859PhosphorylationLYRNHSTSFSLSNLT
HHHCCCCCCEECCCC		18.8225521595
861PhosphorylationRNHSTSFSLSNLTLP
HCCCCCCEECCCCCC		30.5621454597
862 (in isoform 11)Phosphorylation-3.5627841257
863PhosphorylationHSTSFSLSNLTLPTK
CCCCCEECCCCCCCC		28.7029899451
866PhosphorylationSFSLSNLTLPTKGAR
CCEECCCCCCCCCCC		34.6429472430
869PhosphorylationLSNLTLPTKGAREKT
ECCCCCCCCCCCCCC		45.2629472430
881PhosphorylationEKTTPFPSLKVFGLN
CCCCCCCCCEEECHH		41.0028833060
881 (in isoform 13)Phosphorylation-41.0027841257
881 (in isoform 14)Phosphorylation-41.0027841257
881 (in isoform 3)Phosphorylation-41.0027841257
881 (in isoform 8)Phosphorylation-41.0027841257
915PhosphorylationALVDQKSSVIKHSPT
HHHCCCCHHCCCCCC		34.5929899451
920PhosphorylationKSSVIKHSPTVKREP
CCHHCCCCCCCCCCC		19.7722324799
922PhosphorylationSVIKHSPTVKREPSS
HHCCCCCCCCCCCCC		41.4922324799
928PhosphorylationPTVKREPSSPQGRSS
CCCCCCCCCCCCCCC		50.3125521595
929PhosphorylationTVKREPSSPQGRSSN
CCCCCCCCCCCCCCC		31.7725521595
934PhosphorylationPSSPQGRSSNSSENQ
CCCCCCCCCCCHHHH		40.4726643407
935PhosphorylationSSPQGRSSNSSENQQ
CCCCCCCCCCHHHHH		39.0926643407
937PhosphorylationPQGRSSNSSENQQFL
CCCCCCCCHHHHHHH		40.7626643407
938PhosphorylationQGRSSNSSENQQFLK
CCCCCCCHHHHHHHH		44.8326643407
981UbiquitinationLRVFVLSKLNRAVQS
HHHHHHHHHHHHHCC		45.69-
1003PhosphorylationVIQDVEISRKVYKGM
HHHHHHHHHHHHHHH		16.7322942356
1058PhosphorylationEPDKRKRSPTENVNT
CCCCCCCCCCCCCCC		38.9325521595
1060PhosphorylationDKRKRSPTENVNTPV
CCCCCCCCCCCCCCC		41.2525521595
1065PhosphorylationSPTENVNTPVGKDPG
CCCCCCCCCCCCCCC		18.3128833060
1107PhosphorylationKGPKELDTRSLKEEN
CCCCCCCCCCHHHHC		34.4829899451
1109PhosphorylationPKELDTRSLKEENFV
CCCCCCCCHHHHCCH		45.9829899451
1118PhosphorylationKEENFVASVELWNKH
HHHCCHHHHHHHHHH		15.7220415495
1126 (in isoform 5)Phosphorylation-59.8025293948
1127 (in isoform 5)Phosphorylation-56.9025293948
1128 (in isoform 5)Phosphorylation-8.2625293948
1131 (in isoform 5)Phosphorylation-30.4525293948
1132 (in isoform 11)Phosphorylation-64.9125293948
1133 (in isoform 11)Phosphorylation-20.6125293948
1134 (in isoform 11)Phosphorylation-12.4525293948
1134 (in isoform 5)Phosphorylation-12.4525293948
1135 (in isoform 5)Phosphorylation-52.5925293948
1137 (in isoform 11)Phosphorylation-57.7025293948
1138 (in isoform 5)Phosphorylation-42.1625293948
1140 (in isoform 11)Phosphorylation-75.6125293948
1140 (in isoform 5)Phosphorylation-75.6125293948
1141 (in isoform 11)Phosphorylation-35.5825293948
1144 (in isoform 11)Phosphorylation-30.0425293948
1144 (in isoform 5)Phosphorylation-30.0425293948
1146 (in isoform 11)Phosphorylation-9.7125293948
1150 (in isoform 11)Phosphorylation-61.4125293948
1151 (in isoform 8)Phosphorylation-47.8725293948
1152 (in isoform 7)Phosphorylation-64.6125293948
1152 (in isoform 8)Phosphorylation-64.6125293948
1153 (in isoform 7)Phosphorylation-73.5325293948
1153 (in isoform 8)Phosphorylation-73.5325293948
1154 (in isoform 7)Phosphorylation-52.0425293948
1156 (in isoform 8)Phosphorylation-42.0325293948
1157 (in isoform 7)Phosphorylation-38.4425293948
1159 (in isoform 8)Phosphorylation-22.6825293948
1160 (in isoform 7)Phosphorylation-15.0525293948
1160 (in isoform 8)Phosphorylation-15.0525293948
1161 (in isoform 7)Phosphorylation-38.3225293948
1163 (in isoform 8)Phosphorylation-17.3625293948
1164 (in isoform 7)Phosphorylation-4.9925293948
1165 (in isoform 8)Phosphorylation-29.4725293948
1166 (in isoform 7)Phosphorylation-3.9925293948
1169 (in isoform 14)Phosphorylation-12.4025293948
1169 (in isoform 3)Phosphorylation-12.4025293948
1169 (in isoform 8)Phosphorylation-12.4025293948
1170 (in isoform 14)Phosphorylation-21.6925293948
1170 (in isoform 3)Phosphorylation-21.6925293948
1170 (in isoform 7)Phosphorylation-21.6925293948
1171 (in isoform 14)Phosphorylation-52.5925293948
1171 (in isoform 3)Phosphorylation-52.5925293948
1171 (in isoform 4)Phosphorylation-52.5925293948
1172 (in isoform 4)Phosphorylation-37.4625293948
1173 (in isoform 4)Phosphorylation-30.3025293948
1174 (in isoform 14)Phosphorylation-53.1025293948
1174 (in isoform 3)Phosphorylation-53.1025293948
1176 (in isoform 4)Phosphorylation-47.9125293948
1177PhosphorylationSQRTDQDSVIGVSPA
HHCCCCCCCCEECCE		15.2529899451
1177 (in isoform 14)Phosphorylation-15.2525293948
1177 (in isoform 3)Phosphorylation-15.2525293948
1178 (in isoform 14)Phosphorylation-6.2525293948
1178 (in isoform 3)Phosphorylation-6.2525293948
1179 (in isoform 4)Phosphorylation-5.3725293948
1180 (in isoform 4)Phosphorylation-16.2225293948
1181 (in isoform 14)Phosphorylation-4.2125293948
1181 (in isoform 3)Phosphorylation-4.2125293948
1183 (in isoform 14)Phosphorylation-26.8525293948
1183 (in isoform 3)Phosphorylation-26.8525293948
1183 (in isoform 4)Phosphorylation-26.8525293948
1185 (in isoform 4)Phosphorylation-3.5825293948
1187 (in isoform 14)Phosphorylation-2.8825293948
1187 (in isoform 3)Phosphorylation-2.8825293948
1189PhosphorylationSPAVMIRSSSQDSEV
CCEEEEECCCCCCCC		24.3425338131
1189 (in isoform 2)Phosphorylation-24.3425293948
1189 (in isoform 4)Phosphorylation-24.3425293948
1190 (in isoform 2)Phosphorylation-23.3625293948
1191PhosphorylationAVMIRSSSQDSEVST
EEEEECCCCCCCCEE		38.9721183079
1191 (in isoform 2)Phosphorylation-38.9725293948
1194 (in isoform 2)Phosphorylation-32.0625293948
1197 (in isoform 2)Phosphorylation-21.0225293948
1198 (in isoform 2)Phosphorylation-32.8825293948
1201 (in isoform 2)Phosphorylation-35.5425293948
1203 (in isoform 2)Phosphorylation-44.9225293948
1207 (in isoform 2)Phosphorylation-4.6625293948
1218PhosphorylationSDLSSNAGDGPGGEG
CCCCCCCCCCCCCCC		44.6624719451
1235PhosphorylationHLASSRATLSDSEIE
HHHHCCCCCCHHHHC		26.1925521595
1237PhosphorylationASSRATLSDSEIETN
HHCCCCCCHHHHCCC		34.4325521595
1239PhosphorylationSRATLSDSEIETNSA
CCCCCCHHHHCCCHH		36.7825521595
1243PhosphorylationLSDSEIETNSATSAI
CCHHHHCCCHHHHHH		39.8825521595
1245PhosphorylationDSEIETNSATSAIFG
HHHHCCCHHHHHHHC		40.1028833060
1247PhosphorylationEIETNSATSAIFGKA
HHCCCHHHHHHHCCH		20.6428833060
1248PhosphorylationIETNSATSAIFGKAH
HCCCHHHHHHHCCHH		21.0528833060
1266PhosphorylationPKEKPAGSPIRSSED
CCCCCCCCCCCCCCC		21.1825521595
1270PhosphorylationPAGSPIRSSEDVSQR
CCCCCCCCCCCHHHH		38.5122324799
1271PhosphorylationAGSPIRSSEDVSQRV
CCCCCCCCCCHHHHH		28.1522324799
1350PhosphorylationEMIDRYLSLGEHDRK
HHHHHHHHCCHHHHH		25.9520415495
1406PhosphorylationSHIGLVYSQQVNEVL
CCHHHHHHHHHHHHH		13.4724719451
1410PhosphorylationLVYSQQVNEVLDQLN
HHHHHHHHHHHHHHH		29.3524719451
1429PhosphorylationRDLSIRSSGSRHMKK
CCCEECCCCCCCCCE		30.82-
1490 (in isoform 10)Phosphorylation-5.7422807455
1496 (in isoform 10)Phosphorylation-40.0325338131
1497 (in isoform 10)Phosphorylation-50.1722807455
1499PhosphorylationCLWRRNGSETQLNKF
EEEECCCCHHHHHHH		40.8120415495
1499 (in isoform 9)Phosphorylation-40.8122807455
1501PhosphorylationWRRNGSETQLNKFYT
EECCCCHHHHHHHHH		39.8020415495
1505 (in isoform 9)Phosphorylation-48.6325338131
1506 (in isoform 9)Phosphorylation-10.2222807455
1514 (in isoform 6)Phosphorylation-1.5822807455
1518 (in isoform 5)Phosphorylation-4.4522807455
1520 (in isoform 6)Phosphorylation-32.5925338131
1521 (in isoform 6)Phosphorylation-19.4722807455
1524 (in isoform 5)Phosphorylation-22.3825338131
1525 (in isoform 5)Phosphorylation-7.6822807455
1531PhosphorylationRAAARQQSIKPGPEL
HHHHHHCCCCCCCCC		25.0021183079
1620 (in isoform 14)Phosphorylation-22807455
1626 (in isoform 14)Phosphorylation-25338131
1627 (in isoform 14)Phosphorylation-22807455
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MADD_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MADD_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MADD_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MADD_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MADD_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1058 AND THR-1060, ANDMASS SPECTROMETRY.

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