CNTN4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CNTN4_MOUSE
• UniProt AC: Q69Z26
• Protein Name: Contactin-4
• Gene Name: Cntn4
• Organism: Mus musculus (Mouse).
• Sequence Length: 1026
• Subcellular Localization: Cell membrane; Lipid-anchor, GPI-anchor. Secreted.
• Protein Description: Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis..
• Protein Sequence: MRLPWELLVLQSFMLCLADDYTLHGPVFVQEPSHVMFPLDSEEKKVKLSCEVKGNPKPHIRWKINGTDVDIGMDFRYSVVDGSLLINNPNKTQDAGTYQCIATNSFGTIVSREAKLQFAYLENFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPAEKGTTVKLECFALGNPVPTILWRRADGKPIARKARRHKSNGILEIPNFQQEDAGSYECVAENSRGKNVAKGQLTFYAQPNWVQIINDIHVAMEESVFWECKANGRPKPTYRWLKNGDPLLTRDRIQIEQGTLNITIVNLSDAGMYQCVAENKHGVIFSSAELSVIAESPDFSRTLLKRVTLVKVGGEVVIECKPKASPRPVYTWRKGREILRENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNVIVKDPTKVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWTFNGHLIDFDKDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDKLSVAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVNTVPDLVDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPHGKMIWMLTVLASADASRYVFRNESVRPFSPFEVKVGVFNNKGEGPFSPTTLVYSAEEEPTKPPASIFARSLSATDIEVFWASPIGKNRGRIQGYEVKYWRHDDKEENAKKIRTVGNQTSTKITNLKGSALYHLSVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIRIPKISNSYARGSGASTSNACTLSAISTIMISLTARSSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	N-linked_Glycosylation	PHIRWKINGTDVDIG CCEEEEECCEEEECC	43.51	20133774
90	N-linked_Glycosylation	SLLINNPNKTQDAGT CEEECCCCCCCCCCE	63.23	20133774
191	N-linked_Glycosylation	VEKSDVGNYTCVVTN EEECCCCCEEEEEEE	28.87	20133774
370	N-linked_Glycosylation	QIEQGTLNITIVNLS EEECCEEEEEEEEHH	29.24	20133774
375	N-linked_Glycosylation	TLNITIVNLSDAGMY EEEEEEEEHHHCCCE	29.94	-
411	Phosphorylation	ESPDFSRTLLKRVTL CCCCHHHHHHHEEEE	34.93	-
466	N-linked_Glycosylation	DGNLRIINVTKSDAG CCCEEEEEEECCCCC	32.79	-
694	Phosphorylation	RPSEKRRTEEALPEV CHHHCCCCHHCCCCC	42.06	29899451
705	N-linked_Glycosylation	LPEVTPANVSGGGGS CCCCCCCCCCCCCCC	29.68	-
707	Phosphorylation	EVTPANVSGGGGSKS CCCCCCCCCCCCCCC	31.37	29899451
712	Phosphorylation	NVSGGGGSKSELVIT CCCCCCCCCCEEEEE	35.96	29899451
764	N-linked_Glycosylation	ASRYVFRNESVRPFS HHHHEECCCCCCCCC	34.14	-
858	N-linked_Glycosylation	KKIRTVGNQTSTKIT HEEEECCCCCCCEEE	37.31	-
865	Phosphorylation	NQTSTKITNLKGSAL CCCCCEEECCCCCEE	35.73	-
870	Phosphorylation	KITNLKGSALYHLSV EEECCCCCEEEEEEE	17.32	-
873	Phosphorylation	NLKGSALYHLSVKAY CCCCCEEEEEEEEEE	10.63	-
893	N-linked_Glycosylation	GPSSATVNVTTRKPP CCCCCEEEEEECCCC	22.51	-
911	N-linked_Glycosylation	PPGNIIWNSSDSKII CCCCEEECCCCCEEE	22.64	-
929	N-linked_Glycosylation	DQVKALDNESEVKGY HHEEECCCHHHHCCE	56.39	-
940	Phosphorylation	VKGYKVLYRWNRQSS HCCEEEEEEEECCCC	19.30	28978645
946	Phosphorylation	LYRWNRQSSTSVIET EEEEECCCCCEEEEC	32.14	28978645
947	Phosphorylation	YRWNRQSSTSVIETN EEEECCCCCEEEECC	19.16	28978645
948	Phosphorylation	RWNRQSSTSVIETNK EEECCCCCEEEECCC	32.06	28978645
954	N-linked_Glycosylation	STSVIETNKTSVELS CCEEEECCCCEEEEE	32.58	-
1000	GPI-anchor	SNSYARGSGASTSNA CCCCCCCCCCCCCCH	26.15	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CNTN4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CNTN4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CNTN4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CNTN4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.