GIPC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GIPC1_MOUSE
• UniProt AC: Q9Z0G0
• Protein Name: PDZ domain-containing protein GIPC1
• Gene Name: Gipc1
• Organism: Mus musculus (Mouse).
• Sequence Length: 333
• Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein.
• Protein Description: Inhibits endothelial cell migration (in vitro). May be involved in G protein-linked signaling (By similarity)..
• Protein Sequence: MPLGLGRRKKAPPLVENEEAEPSRSGLGVGEPGPLGGSAAGESQMGLPPPPAALRPRLVFHTQLAHGSPTGRIEGFTNVKELYGKIAEAFRLPAAEVMFCTLNTHKVDMDKLLGGQIGLEDFIFAHVKGQRKEVEVFKSEEALGLTITDNGAGYAFIKRIKEGSVIDHIQLISVGDMIEAINGQSLLGCRHYEVARLLKELPRGRTFTLKLTEPRKAFDMISQRSAGGHPGSGPQLGTGRGTLRLRSRGPATVEDLPSAFEEKAIEKVDDLLESYMGIRDTELAATMVELGKDKRNPDELAEALDERLGDFAFPDEFVFDVWGAIGDAKVGRY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
68	Phosphorylation	HTQLAHGSPTGRIEG EEECCCCCCCCCEEC	14.93	-
80	Ubiquitination	IEGFTNVKELYGKIA EECCCCHHHHHHHHH	44.03	22790023
222	Phosphorylation	RKAFDMISQRSAGGH HHHHHHHHHCCCCCC	16.95	-
225	Phosphorylation	FDMISQRSAGGHPGS HHHHHHCCCCCCCCC	24.51	30635358
232	Phosphorylation	SAGGHPGSGPQLGTG CCCCCCCCCCCCCCC	52.32	24719451
238	Phosphorylation	GSGPQLGTGRGTLRL CCCCCCCCCCCEEEE	32.09	26824392
240	Dimethylation	GPQLGTGRGTLRLRS CCCCCCCCCEEEEEC	34.46	-
240	Methylation	GPQLGTGRGTLRLRS CCCCCCCCCEEEEEC	34.46	-
242	Phosphorylation	QLGTGRGTLRLRSRG CCCCCCCEEEEECCC	13.82	26239621
247	Phosphorylation	RGTLRLRSRGPATVE CCEEEEECCCCCCHH	46.29	29899451
252	Phosphorylation	LRSRGPATVEDLPSA EECCCCCCHHHCCHH	27.80	29514104
258	Phosphorylation	ATVEDLPSAFEEKAI CCHHHCCHHHHHHHH	53.54	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GIPC1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GIPC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GIPC1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PKHG5_MOUSE	Plekhg5	physical	16467373

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.