PKHG5_MOUSE - dbPTM
PKHG5_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PKHG5_MOUSE
UniProt AC Q66T02
Protein Name Pleckstrin homology domain-containing family G member 5
Gene Name Plekhg5
Organism Mus musculus (Mouse).
Sequence Length 1073
Subcellular Localization Cytoplasm . Cytoplasm, perinuclear region . Cell membrane . Cell junction . Cell projection, lamellipodium . Predominantly cytoplasmic, however when endothelial cells are stimulated with lysophosphatidic acid, PLEKHG5 is found in perinuclear regions
Protein Description Guanine nucleotide exchange factor that activates RHOA and maybe the NF-kappa-B signaling pathway. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis..
Protein Sequence MGTGPGVSGRRAAARPSSELPSPDSQLLWVGGHAHSSDSQVCHHADCQQLHHRGPLNLCETCDSKFHSTLHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAADLEEEEEGCTDGKGDRKSAGLKISKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAKPGDEGKVEQGVKDSKSLSLPALRPSGAGPPVSERVDPQSRRESSLDILAPGRRRKNMSEFLGEAGIPGHEPPAPSSCSLPVGSSGGTSSGINESWKNRAASRFSGFFSSSPSTSAFSREVDKMEQLESKLHAYSLFGLPRMPRRLRFDHDSWEEEEEDDEEDEESSGLRLEDSWRELTDGHEKLTRRQCHQQEAVWELLHTEVSYIRKLRVITNLFLCCLLNLQESGLLCEVEAERLFSNIPEIAKLHRGLWGSVMVPVLEKARRTRALLQPSDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYVTWAEKHQQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTDDPRTKEAIVTMISSVERFIHHVNTCMRQRQERQRLAGVVSRIDAYEVVEGSNDEVDKLLKEFLHLDLTAPMPGTSPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTKVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASSQALCRSWVDTIYNAQNQLQQLRAQLSAQEHPGSQHLQSLEEEEDEQEEEGEESGTSAASSPTILRKSSNSLDSEHCTSDGSTETLAMVVVEPGATLSSPEFEGGPVSSQSDESSLSNTASSVTPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPHPVVEPAPVPQTPSPQPSPRLRRRTPVQLLPRPPRLLKSKSEASLLQLLSGTPAARGVPPAPSRSLSELCLISVAPGVRTQRPLQEGGPGWNGPGMCDPCHGPQLSESENRPSHMTGGPADSARRRCREMPSGTMSRVQSEPPSGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMGTGPGVSGRRAAAR
CCCCCCCCCCCCCCC		32.2819854140
92PhosphorylationSVLARNVSTRSCPPR
CEEEEECCCCCCCCC		22.9623684622
93PhosphorylationVLARNVSTRSCPPRT
EEEEECCCCCCCCCC		23.4823684622
95PhosphorylationARNVSTRSCPPRTSP
EEECCCCCCCCCCCC		30.9423684622
128PhosphorylationKSAGLKISKKKARRR
HHCCCCCCHHHHHHH		36.5129514104
137PhosphorylationKKARRRHTDDPSKEC
HHHHHHCCCCCCCCC		40.0421659605
232PhosphorylationQGVKDSKSLSLPALR
CCCCCCCCCCCCCCC		27.4326643407
234PhosphorylationVKDSKSLSLPALRPS
CCCCCCCCCCCCCCC		39.1227180971
241PhosphorylationSLPALRPSGAGPPVS
CCCCCCCCCCCCCHH		34.5426804993
248PhosphorylationSGAGPPVSERVDPQS
CCCCCCHHHCCCCCC		26.0126804993
259PhosphorylationDPQSRRESSLDILAP
CCCCHHHHHCCHHCC		34.1026824392
260PhosphorylationPQSRRESSLDILAPG
CCCHHHHHCCHHCCC		25.8826643407
291PhosphorylationGHEPPAPSSCSLPVG
CCCCCCCCCCCEECC		46.1926643407
292PhosphorylationHEPPAPSSCSLPVGS
CCCCCCCCCCEECCC		13.4826643407
294PhosphorylationPPAPSSCSLPVGSSG
CCCCCCCCEECCCCC		37.3426643407
299PhosphorylationSCSLPVGSSGGTSSG
CCCEECCCCCCCCCC		26.5026643407
300PhosphorylationCSLPVGSSGGTSSGI
CCEECCCCCCCCCCC		35.0026643407
303PhosphorylationPVGSSGGTSSGINES
ECCCCCCCCCCCCHH		24.2026643407
304PhosphorylationVGSSGGTSSGINESW
CCCCCCCCCCCCHHH		29.8226643407
305PhosphorylationGSSGGTSSGINESWK
CCCCCCCCCCCHHHH		43.4626643407
310PhosphorylationTSSGINESWKNRAAS
CCCCCCHHHHHHHHH		38.5726643407
320PhosphorylationNRAASRFSGFFSSSP
HHHHHHHCCCCCCCC		33.3126643407
324PhosphorylationSRFSGFFSSSPSTSA
HHHCCCCCCCCCCCH		27.8729514104
325PhosphorylationRFSGFFSSSPSTSAF
HHCCCCCCCCCCCHH		40.9026643407
326PhosphorylationFSGFFSSSPSTSAFS
HCCCCCCCCCCCHHH		22.9826643407
328PhosphorylationGFFSSSPSTSAFSRE
CCCCCCCCCCHHHHH		36.6226643407
329PhosphorylationFFSSSPSTSAFSREV
CCCCCCCCCHHHHHH		27.7126643407
330PhosphorylationFSSSPSTSAFSREVD
CCCCCCCCHHHHHHH		31.4926643407
602MethylationVNTCMRQRQERQRLA
HHHHHHHHHHHHHHH		29.9318967797
605MethylationCMRQRQERQRLAGVV
HHHHHHHHHHHHHHH		20.6918967805
791PhosphorylationQEEEGEESGTSAASS
HHHHHHCCCCCCCCC		42.9725338131
793PhosphorylationEEGEESGTSAASSPT
HHHHCCCCCCCCCCC		25.1922817900
794PhosphorylationEGEESGTSAASSPTI
HHHCCCCCCCCCCCE		25.9325338131
797PhosphorylationESGTSAASSPTILRK
CCCCCCCCCCCEECC		36.2525338131
798PhosphorylationSGTSAASSPTILRKS
CCCCCCCCCCEECCC		22.7222817900
806PhosphorylationPTILRKSSNSLDSEH
CCEECCCCCCCCCCC		33.21-
909PhosphorylationEPAPVPQTPSPQPSP
CCCCCCCCCCCCCCC		21.4726643407
911PhosphorylationAPVPQTPSPQPSPRL
CCCCCCCCCCCCCCC		39.2826643407
915PhosphorylationQTPSPQPSPRLRRRT
CCCCCCCCCCCCCCC		19.8726643407
922PhosphorylationSPRLRRRTPVQLLPR
CCCCCCCCCCHHCCC		26.4627180971
936PhosphorylationRPPRLLKSKSEASLL
CCCCCCCCCCHHHHH		41.1925521595
938PhosphorylationPRLLKSKSEASLLQL
CCCCCCCCHHHHHHH		45.5526824392
941PhosphorylationLKSKSEASLLQLLSG
CCCCCHHHHHHHHHC		26.0926824392
947PhosphorylationASLLQLLSGTPAARG
HHHHHHHHCCCCCCC		49.5725777480
949PhosphorylationLLQLLSGTPAARGVP
HHHHHHCCCCCCCCC		13.3325777480
960PhosphorylationRGVPPAPSRSLSELC
CCCCCCCCCCHHHHH		36.2924759943
962PhosphorylationVPPAPSRSLSELCLI
CCCCCCCCHHHHHHE		40.3521082442
964PhosphorylationPAPSRSLSELCLISV
CCCCCCHHHHHHEEC		29.7526824392
970PhosphorylationLSELCLISVAPGVRT
HHHHHHEECCCCCCC		10.1625159016
1037PhosphorylationGTMSRVQSEPPSGVS
CCCCCCCCCCCCCCC		49.5725338131
1041PhosphorylationRVQSEPPSGVSAQHR
CCCCCCCCCCCHHHH		63.6421183079
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
92SPhosphorylationKinasePRKD1Q15139
PSP
806SPhosphorylationKinasePRKD1Q15139
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PKHG5_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PKHG5_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GIPC1_MOUSEGipc1physical
16467373
AMOT_HUMANAMOTphysical
18824598
MPDZ_MOUSEMpdzphysical
18824598
MPP5_MOUSEMpp5physical
18824598
LIN7C_MOUSELin7cphysical
18824598
MYO1C_MOUSEMyo1cphysical
18824598
ACTG_MOUSEActg1physical
18824598
GIPC1_MOUSEGipc1physical
18824598
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PKHG5_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-936; SER-938 ANDSER-964, AND MASS SPECTROMETRY.

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