| UniProt ID | MPP5_MOUSE | |
|---|---|---|
| UniProt AC | Q9JLB2 | |
| Protein Name | MAGUK p55 subfamily member 5 | |
| Gene Name | Mpp5 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 675 | |
| Subcellular Localization |
Cell membrane Peripheral membrane protein. Endomembrane system Peripheral membrane protein. Cell junction, tight junction. Localized to the tight junctions of epithelial cells and a subset of intracellular vesicles. Localized to the Purkinje cell b |
|
| Protein Description | May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton.. | |
| Protein Sequence | MTTSYMNGHVTEESDSGIKNLDLASPEEYPKHREMAVDCPGDLGTRMMPVRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPIFDTEEGIVLESPHYAVNILDVEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNRDFQNAFKIHNAVTVHMSKASPPFPLIANVQDLVQEVQTVLKPVHQKEGQELTALLNAPHIQALLLAHDKVAEQEMQLEPITDERVYESIGHYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRNRRDHEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTEPQWVPSTWLR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 14 | Phosphorylation | NGHVTEESDSGIKNL CCCCCCCCCCCCCCC | 30.74 | - | |
| 25 | Phosphorylation | IKNLDLASPEEYPKH CCCCCCCCHHHCCCC | 39.89 | 25521595 | |
| 29 | Phosphorylation | DLASPEEYPKHREMA CCCCHHHCCCCCHHC | 18.87 | 26239621 | |
| 53 | Phosphorylation | RMMPVRRSAQLERIR CCCCCHHHHHHHHHH | 15.14 | 22324799 | |
| 83 | Phosphorylation | KQELDLNSSMRLKKL HHHCCCCHHHHHHHH | 32.58 | 25619855 | |
| 84 | Phosphorylation | QELDLNSSMRLKKLA HHCCCCHHHHHHHHH | 13.57 | 26824392 | |
| 243 | Phosphorylation | PITDERVYESIGHYG CCCCHHHHHHHCCCC | 15.35 | 29233185 | |
| 245 | Phosphorylation | TDERVYESIGHYGGE CCHHHHHHHCCCCCC | 19.04 | 29514104 | |
| 372 | Phosphorylation | PCRELGLSFQKGDIL CHHHHCCEECCCCEE | 24.67 | 28066266 | |
| 528 | Phosphorylation | HEVAGRDYHFVSRQA CCCCCCCCEEECHHH | 8.87 | - | |
| 544 | Ubiquitination | EADIAAGKFIEHGEF HHHHHCCCCCCCCCC | 38.14 | - | |
| 553 | Ubiquitination | IEHGEFEKNLYGTSI CCCCCCCCCCCCCCH | 58.53 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MPP5_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MPP5_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MPP5_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| YAP1_MOUSE | Yap1 | physical | 21145499 | |
| WWTR1_MOUSE | Wwtr1 | physical | 21145499 | |
| AMOT_HUMAN | AMOT | physical | 18824598 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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