GRID2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRID2_MOUSE
• UniProt AC: Q61625
• Protein Name: Glutamate receptor ionotropic, delta-2
• Gene Name: Grid2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1007
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex..
• Protein Sequence: MEVFPLLLFLSFCWSRTWDLATADSIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLNEVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFISEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSSLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVNGLTGDLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILKHKWWPKNGQCDLYSSVDAKQKGGALDIKSLAGVFCILAAGIVLSCLIAVLETWWSRRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSIDLTPLDIDTLPTRQALEQISDFRNTHITTTTFIPEQIQTLSRTLSAKAASGFAFGSVPEHRTGPFRHRAPNGGFFRSPIKTMSSIPYQPTPTLGLNLGNDPDRGTSI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
100	Phosphorylation	LVSSIGCTSAGSLQS HHHHCCCCCHHHHHH	19.19	-
101	Phosphorylation	VSSIGCTSAGSLQSL HHHCCCCCHHHHHHH	34.41	-
104	Phosphorylation	IGCTSAGSLQSLADA CCCCCHHHHHHHHHH	23.97	-
209	Phosphorylation	NNINKMITTLFDTMR HHHHHHHHHHHHHHC	17.59	25338131
210	Phosphorylation	NINKMITTLFDTMRI HHHHHHHHHHHHHCH	17.95	25338131
293	N-linked_Glycosylation	QTFPVPQNISQRCFR ECCCCCCCHHHHHHC	29.79	-
426	N-linked_Glycosylation	WNPVTGLNGSLTDKK CCCCCCCCCCCCHHH	39.08	-
527	Phosphorylation	GISALTITPDRENVV EEEEEEECCCCHHCC	17.57	28576409
544	Phosphorylation	TTRYMDYSVGVLLRR HHHHHCHHHHHHHHH	14.23	20139300
608	Phosphorylation	TSTTLYNSMWFVYGS CHHHHHHCCEEEHHH	12.11	-
663	Phosphorylation	LTITRIESSIQSLQD HHHHHHHHHHHHHHH	30.30	28464351
664	Phosphorylation	TITRIESSIQSLQDL HHHHHHHHHHHHHHH	16.32	28464351
667	Phosphorylation	RIESSIQSLQDLSKQ HHHHHHHHHHHHHHC	26.74	28464351
672	Phosphorylation	IQSLQDLSKQTDIPY HHHHHHHHHCCCCCC	30.89	28464351
713	N-linked_Glycosylation	SQMWRMINRSNGSEN HHHHHHHHCCCCCCC	31.80	-
716	N-linked_Glycosylation	WRMINRSNGSENNVL HHHHHCCCCCCCCCC	55.56	-
861	Phosphorylation	WWSRRKGSRVPSKED HHHHCCCCCCCCCCC	32.89	29899451
865	Phosphorylation	RKGSRVPSKEDDKEI CCCCCCCCCCCCCCC	45.91	22817900
883	Phosphorylation	HLHRRVNSLCTDDDS HHHHHHHHHCCCCCC	23.20	25521595
886	Phosphorylation	RRVNSLCTDDDSPHK HHHHHHCCCCCCCCC	47.99	22324799
890	Phosphorylation	SLCTDDDSPHKQFST HHCCCCCCCCCCCCC	35.58	22324799
896	Phosphorylation	DSPHKQFSTSSIDLT CCCCCCCCCCCCCCC	25.53	24925903
897	Phosphorylation	SPHKQFSTSSIDLTP CCCCCCCCCCCCCCC	27.99	24925903
898	Phosphorylation	PHKQFSTSSIDLTPL CCCCCCCCCCCCCCC	24.89	24925903
899	Phosphorylation	HKQFSTSSIDLTPLD CCCCCCCCCCCCCCC	21.88	25521595
903	Phosphorylation	STSSIDLTPLDIDTL CCCCCCCCCCCCCCC	20.32	24925903
909	Phosphorylation	LTPLDIDTLPTRQAL CCCCCCCCCCHHHHH	34.66	29899451
939	Phosphorylation	FIPEQIQTLSRTLSA CCHHHHHHHHHHHCH	28.47	29899451
945	Phosphorylation	QTLSRTLSAKAASGF HHHHHHHCHHHHCCC	27.40	16197524
947	Ubiquitination	LSRTLSAKAASGFAF HHHHHCHHHHCCCCC	40.90	22790023
956	Phosphorylation	ASGFAFGSVPEHRTG HCCCCCCCCCCCCCC	28.22	29899451
977	Phosphorylation	PNGGFFRSPIKTMSS CCCCCCCCCCCCCCC	26.31	25521595
992	Phosphorylation	IPYQPTPTLGLNLGN CCCCCCCCCCCCCCC	35.62	29899451
1005	Phosphorylation	GNDPDRGTSI----- CCCCCCCCCC-----	24.92	29899451
1006	Phosphorylation	NDPDRGTSI------ CCCCCCCCC------	29.17	24925903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
945	S	Phosphorylation	Kinase	PRKCA	P17252	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRID2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRID2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GRID2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.