KBP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KBP_MOUSE
• UniProt AC: Q6ZPU9
• Protein Name: KIF1-binding protein {ECO:0000250|UniProtKB:Q96EK5}
• Gene Name: Kif1bp {ECO:0000250|UniProtKB:Q96EK5}
• Organism: Mus musculus (Mouse).
• Sequence Length: 617
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Required for neuronal development and differentiation. Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development..
• Protein Sequence: MANAPGPEIREKFQAALALSRVELHKNPEKEPYKSKYGARALLEEVRALLGPAPEDEDEPAADDGPGDQALGAGEPREAEGPGAQRALRLAVVEFHLGVNHIDTEELSAGEEHLVRCLSLLRPYRLSLGCVSLYIQAQNNLGILWSEREEIETARTYLESSEALYSQYMKEIGSPPLDPTEHFLPEEEKLTEQERSKRFEKVYTHNLYYLAQVYQHMEMFEKAAHYCHSTLKRQLEHNAYHPMEWAINAATLSQFYINKLCFMEARHCLSAANVIFGQTGKIPATEDTPEVEGDVPELYHQRKGEIARCWIKYCLTLMQNAQLSMQDNIGELDLDKQSELRALRKKELDEEESVRKRAVQFGTGELCDAISAVEEKVRYLRPLDFEEARELFLLGQHYVCEAKEFFQIDGYVTDHIEVVQDHSALFKVLSFFEADMERRCKMHKRRIAMLEPLTVDLNPQYYLLVSRQIQFEIAHAYYDMMDLKVAIADKLRDPDSHIVKKINSLNKSALKYYQLFLDSLRDPNKVFPEHIGEDVLRPAMLAKFRVARLYGKIITADPKKELENLATSLEHYKFIVDYCETHPEAAQEIEVELELSKEMVSLLPTKMERFRAKMALT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
161	Phosphorylation	ARTYLESSEALYSQY HHHHHHCHHHHHHHH	19.95	-
166	Phosphorylation	ESSEALYSQYMKEIG HCHHHHHHHHHHHHC	18.71	-
168	Phosphorylation	SEALYSQYMKEIGSP HHHHHHHHHHHHCCC	12.29	-
174	Phosphorylation	QYMKEIGSPPLDPTE HHHHHHCCCCCCCCC	29.07	28066266
477	Phosphorylation	QFEIAHAYYDMMDLK HHHHHHHHHHHHHHH	7.07	28507225
490	Ubiquitination	LKVAIADKLRDPDSH HHHHHHHHCCCCCCH	36.08	22790023
496	Phosphorylation	DKLRDPDSHIVKKIN HHCCCCCCHHHHHHH	22.09	26824392
504	Phosphorylation	HIVKKINSLNKSALK HHHHHHHHCCHHHHH	36.47	25338131
507	Ubiquitination	KKINSLNKSALKYYQ HHHHHCCHHHHHHHH	42.26	27667366
543	Ubiquitination	LRPAMLAKFRVARLY HHHHHHHHHHHHHHH	29.73	22790023
552	Ubiquitination	RVARLYGKIITADPK HHHHHHCCEECCCCH	19.85	22790023
559	Ubiquitination	KIITADPKKELENLA CEECCCCHHHHHHHH	60.47	27667366
560	Ubiquitination	IITADPKKELENLAT EECCCCHHHHHHHHH	73.29	22790023
606	Ubiquitination	MVSLLPTKMERFRAK HHHHCCHHHHHHHHH	36.50	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KBP_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KBP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KBP_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACTB_HUMAN	ACTB	physical	26496610
AP2B1_HUMAN	AP2B1	physical	26496610
ERCC5_HUMAN	ERCC5	physical	26496610
MYL6_HUMAN	MYL6	physical	26496610
MYPT1_HUMAN	PPP1R12A	physical	26496610
SPG7_HUMAN	SPG7	physical	26496610
SPTN1_HUMAN	SPTAN1	physical	26496610
TAF1_HUMAN	TAF1	physical	26496610
TPM1_HUMAN	TPM1	physical	26496610
TPM4_HUMAN	TPM4	physical	26496610
AK17A_HUMAN	AKAP17A	physical	26496610
SC16A_HUMAN	SEC16A	physical	26496610
KIF14_HUMAN	KIF14	physical	26496610
TMOD3_HUMAN	TMOD3	physical	26496610
FEM1A_HUMAN	FEM1A	physical	26496610
MIER1_HUMAN	MIER1	physical	26496610
CHD9_HUMAN	CHD9	physical	26496610
KI18A_HUMAN	KIF18A	physical	26496610
KLC3_HUMAN	KLC3	physical	26496610
CA052_HUMAN	C1orf52	physical	26496610
MY18A_HUMAN	MYO18A	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.