RAI1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAI1_MOUSE
• UniProt AC: Q61818
• Protein Name: Retinoic acid-induced protein 1
• Gene Name: Rai1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1889
• Subcellular Localization: Cytoplasm. Nucleus. In neurons, localized to neurites.
• Protein Description: Transcriptional regulator of the circadian clock components: CLOCK, ARNTL/BMAL1, ARNTL2/BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation..
• Protein Sequence: MQSFRERCGFHGKQQNYPQTSQETSRLENYRQPGQAGLSCDRQRLLAKDYYSPQPYTGYEGGTGTPSGTVATAAADKYHRGSKSLQGRPAFPSYVQDSSPYPGRYSGEEGLQTWGGPQPPPPQPQPLPGAVSKYEENLMKKTVVPPPNRQYPEQGPQLPFRTHSLHVPPPQPQQPLAYPKLQRQKPQNDLASPLPFPQGSHFPQHSQSFPTSSTYAPTVQGGGQGAHSYKSCTAPSAQPHDRPMSANANLAPGQRVQNLHAYQPGRLGYEQQQQALQGRHHTQETLHYQNLAKYQHYGQQGQGYCPPDTAVRTPEQYYQTFSPSSSHSPARSVGRSPSYSSTPSPLMPNLENFPYSQQPLSTGAFPTGITDHSHFMPLLNPSPTDAASSVDPQAGNCKPLQKEKLPDNLLSDLSLQSLTALTSQVENISNTVQQLLLSKATMPQKKGVKNLVSRTPEQHKSQHCSPEGSGYSAEPAGTPLSEPPSSTPQSTHAEPQDTDYLSGSEDPLERSFLYCSQARGSPARVNSNSKAKPESVSTCSVTSPDDMSTKSDDSFQSLHSTLPLDSFSKFVAGERDCPRLLLSALAQEDLASEILGLQEAIVEKADKAWAEASSLPKDNGKPPFSLENHGACLDTVAKTSWSQPGEPETLPEPLQLDKGGSTKDFSPGLFEDPSVAFATTDPKKTSSPLSFGTKPLLGTATPDPTTAAFDCFPDTPTASSVDGANPFAWPEENLGDACPRWGLHPGELTKGLEQGAKASDGVGKADAHEASACMGFQEDHAIGKPAAALSGDFKQQEAEGVKEEVGGLLQCPEVAKANQWLEESRHCCSSTDFGDLPLLPPPGRKEDLEAEEEYSSLCELLGSPEQRPSLQDPLSPKAPLMCTKEEAEEALDTKAGWVSPCHLSGEPAVLLGPSVGAQSKVQSWFESSLSHMKPGEEGPEMERAPGSSGTSQGSLAPKPNKPAVPEGPIAKKEPVPRGKSLRSRRVHRGLPEAEDSPCRVPALPKDLLLPESCTGPPQGQAEGAGAPGRGLSEGLPRMCTRSLTALSEPQTPGPPGLTTTPTPPDKLGGKQRAAFKSGKRVGKPSPKAASSPSNPAALPVASDSSPMGSKTKEPDSPSMPGKDQRSMVLRSRTKPQQVFHAKRRRPSESRIPDCRATKKLPANNHLPTAYKVSSGPQKEGRMNQRVKVPKPGTGNKLSDRPLHTLKRKSAFMAPVPAKKRSLILRSNNGSGGDGREERAESSPGLLRRMASPQRARPRGSGEPPPPPPLEPPAACMGLSTQSSLPSAVRTKVLPPRKGRGLKLEAIVQKITSPGLKKLACRVAGAPPGTPRSPALPERRPGGSPAGAEEGLGGMGQMLPAASGADPLCRNPASRSLKGKLLNSKKLSSAADCPKAEAFMSPETLPSLGTARAPKKRSRKGRTGTLGPSKGPLEKRPCPGQPLLLAPHDRASSTQGGGEDNSSGGGKKPKTEELGPASQPPEGRPCQPQTRAQKQPGQASYSSYSKRKRLSRGRGKTAHASPCKGRATRRRQQQVLPLDPAEPEIRLKYISSCKRLRADSRTPAFSPFVRVEKRDAYTTICTVVNSPGDEPKPHWKPSSSAASSSTSSSSLEPAGASLTTFPGGSVLQQRPSLPLSSTMHLGPVVSKALSTSCLVCCLCQNPANFKDLGDLCGPYYPEHCLPKKKPKLKEKARLEGTLEEASLPLERTLKGLECSASTTAAAPTTATITTPTALGRLSRPDGPADPAKQGPLRTSARGLSRRLQSCYCCDGQGDGGEEVAQADKSRKHECSKEAPTEPGGDTQEHWVHEACAVWTSGVYLVAGKLFGLQEAMKVAVDMPCTSCHEPGATISCSYKGCIHTYHYPCANDTGCTFIEENFTLKCPKHKRLPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Phosphorylation	QRLLAKDYYSPQPYT HHHCHHCCCCCCCCC	12.72	26643407
51	Phosphorylation	RLLAKDYYSPQPYTG HHCHHCCCCCCCCCC	24.82	26643407
52	Phosphorylation	LLAKDYYSPQPYTGY HCHHCCCCCCCCCCC	15.72	26643407
56	Phosphorylation	DYYSPQPYTGYEGGT CCCCCCCCCCCCCCC	13.93	26643407
57	Phosphorylation	YYSPQPYTGYEGGTG CCCCCCCCCCCCCCC	39.71	26643407
59	Phosphorylation	SPQPYTGYEGGTGTP CCCCCCCCCCCCCCC	12.00	26643407
63	Phosphorylation	YTGYEGGTGTPSGTV CCCCCCCCCCCCCCH	49.06	26643407
320	Phosphorylation	TPEQYYQTFSPSSSH CHHHHHHHCCCCCCC	15.23	26643407
322	Phosphorylation	EQYYQTFSPSSSHSP HHHHHHCCCCCCCCC	27.53	26643407
324	Phosphorylation	YYQTFSPSSSHSPAR HHHHCCCCCCCCCCC	43.18	26643407
325	Phosphorylation	YQTFSPSSSHSPARS HHHCCCCCCCCCCCC	35.14	26643407
326	Phosphorylation	QTFSPSSSHSPARSV HHCCCCCCCCCCCCC	32.11	26643407
328	Phosphorylation	FSPSSSHSPARSVGR CCCCCCCCCCCCCCC	23.39	23684622
453	Phosphorylation	KGVKNLVSRTPEQHK HCHHCHHHCCHHHHH	33.33	23984901
455	Phosphorylation	VKNLVSRTPEQHKSQ HHCHHHCCHHHHHHC	24.54	26824392
511	Phosphorylation	SEDPLERSFLYCSQA CCCHHHHHHHHHHCC	15.38	26643407
514	Phosphorylation	PLERSFLYCSQARGS HHHHHHHHHHCCCCC	6.50	26643407
516	Phosphorylation	ERSFLYCSQARGSPA HHHHHHHHCCCCCCC	17.20	27600695
521	Phosphorylation	YCSQARGSPARVNSN HHHCCCCCCCCCCCC	15.16	26745281
527	Phosphorylation	GSPARVNSNSKAKPE CCCCCCCCCCCCCCC	39.36	26643407
529	Phosphorylation	PARVNSNSKAKPESV CCCCCCCCCCCCCCC	33.54	26643407
542	Phosphorylation	SVSTCSVTSPDDMST CCCCCEECCCCCCCC	20.46	25521595
543	Phosphorylation	VSTCSVTSPDDMSTK CCCCEECCCCCCCCC	24.95	25521595
551	Phosphorylation	PDDMSTKSDDSFQSL CCCCCCCCCCCHHHH	46.90	29550500
554	Phosphorylation	MSTKSDDSFQSLHST CCCCCCCCHHHHHHC	30.12	29550500
557	Phosphorylation	KSDDSFQSLHSTLPL CCCCCHHHHHHCCCH	26.49	29550500
560	Phosphorylation	DSFQSLHSTLPLDSF CCHHHHHHCCCHHHH	36.61	29550500
561	Phosphorylation	SFQSLHSTLPLDSFS CHHHHHHCCCHHHHH	22.96	29550500
666	Phosphorylation	GGSTKDFSPGLFEDP CCCCCCCCCCCCCCC	28.35	26824392
674	Phosphorylation	PGLFEDPSVAFATTD CCCCCCCCEEEEECC	38.10	26239621
679	Phosphorylation	DPSVAFATTDPKKTS CCCEEEEECCCCCCC	25.86	-
680	Phosphorylation	PSVAFATTDPKKTSS CCEEEEECCCCCCCC	47.04	-
685	Phosphorylation	ATTDPKKTSSPLSFG EECCCCCCCCCCCCC	40.33	29550500
686	Phosphorylation	TTDPKKTSSPLSFGT ECCCCCCCCCCCCCC	38.55	26643407
687	Phosphorylation	TDPKKTSSPLSFGTK CCCCCCCCCCCCCCC	34.78	26643407
690	Phosphorylation	KKTSSPLSFGTKPLL CCCCCCCCCCCCCCC	25.64	23984901
693	Phosphorylation	SSPLSFGTKPLLGTA CCCCCCCCCCCCCCC	27.72	23984901
790	Phosphorylation	GKPAAALSGDFKQQE CCHHHHHCCCHHHHH	31.43	-
855	Phosphorylation	LEAEEEYSSLCELLG HHHHHHHHHHHHHHC	21.80	21183079
856	Phosphorylation	EAEEEYSSLCELLGS HHHHHHHHHHHHHCC	35.82	-
863	Phosphorylation	SLCELLGSPEQRPSL HHHHHHCCHHHCCCC	25.82	21183079
875	Phosphorylation	PSLQDPLSPKAPLMC CCCCCCCCCCCCCCC	29.73	28418008
899	Phosphorylation	DTKAGWVSPCHLSGE HCCCCCCCCCCCCCC	18.46	22942356
904	Phosphorylation	WVSPCHLSGEPAVLL CCCCCCCCCCCEEEE	19.90	26824392
951	Phosphorylation	APGSSGTSQGSLAPK CCCCCCCCCCCCCCC	35.75	27841257
983	Phosphorylation	PRGKSLRSRRVHRGL CCCCCHHHHCHHCCC	29.72	-
996	Phosphorylation	GLPEAEDSPCRVPAL CCCCCCCCCCCCCCC	19.87	28066266
1012	Phosphorylation	KDLLLPESCTGPPQG HHHCCCCCCCCCCCC	18.29	26239621
1014	Phosphorylation	LLLPESCTGPPQGQA HCCCCCCCCCCCCCC	63.10	26239621
1042	Phosphorylation	LPRMCTRSLTALSEP HHHHHCHHHHHCCCC	16.36	20047950
1044	Phosphorylation	RMCTRSLTALSEPQT HHHCHHHHHCCCCCC	27.14	26060331
1047	Phosphorylation	TRSLTALSEPQTPGP CHHHHHCCCCCCCCC	44.78	-
1051	Phosphorylation	TALSEPQTPGPPGLT HHCCCCCCCCCCCCC	40.71	26824392
1058	Phosphorylation	TPGPPGLTTTPTPPD CCCCCCCCCCCCCCH	34.24	20047950
1060	Phosphorylation	GPPGLTTTPTPPDKL CCCCCCCCCCCCHHC	21.67	26745281
1062	Phosphorylation	PGLTTTPTPPDKLGG CCCCCCCCCCHHCCC	45.41	26745281
1066	Acetylation	TTPTPPDKLGGKQRA CCCCCCHHCCCCCHH	55.60	22826441
1070	Acetylation	PPDKLGGKQRAAFKS CCHHCCCCCHHHHHC	34.51	22826441
1076	Acetylation	GKQRAAFKSGKRVGK CCCHHHHHCCCCCCC	54.28	24431385
1077	Phosphorylation	KQRAAFKSGKRVGKP CCHHHHHCCCCCCCC	42.99	-
1079	Acetylation	RAAFKSGKRVGKPSP HHHHHCCCCCCCCCC	51.51	24431393
1085	Phosphorylation	GKRVGKPSPKAASSP CCCCCCCCCCCCCCC	42.38	22817900
1090	Phosphorylation	KPSPKAASSPSNPAA CCCCCCCCCCCCCCC	47.87	21082442
1091	Phosphorylation	PSPKAASSPSNPAAL CCCCCCCCCCCCCCC	27.85	23527152
1093	Phosphorylation	PKAASSPSNPAALPV CCCCCCCCCCCCCCC	58.35	25521595
1102	Phosphorylation	PAALPVASDSSPMGS CCCCCCCCCCCCCCC	37.95	25619855
1104	Phosphorylation	ALPVASDSSPMGSKT CCCCCCCCCCCCCCC	33.57	27087446
1105	Phosphorylation	LPVASDSSPMGSKTK CCCCCCCCCCCCCCC	24.72	23527152
1109	Phosphorylation	SDSSPMGSKTKEPDS CCCCCCCCCCCCCCC	30.79	21082442
1111	Phosphorylation	SSPMGSKTKEPDSPS CCCCCCCCCCCCCCC	42.19	25159016
1116	Phosphorylation	SKTKEPDSPSMPGKD CCCCCCCCCCCCCCC	29.59	25521595
1118	Phosphorylation	TKEPDSPSMPGKDQR CCCCCCCCCCCCCHH	41.37	25159016
1122	Acetylation	DSPSMPGKDQRSMVL CCCCCCCCCHHHHHH	44.83	23806337
1134	Acetylation	MVLRSRTKPQQVFHA HHHHCCCCHHHHHHC	39.45	15607545
1142	Acetylation	PQQVFHAKRRRPSES HHHHHHCCCCCCCHH	37.56	15607553
1209	Phosphorylation	LHTLKRKSAFMAPVP CCHHCCCCCCCCCCC	30.67	28066266
1230	Phosphorylation	ILRSNNGSGGDGREE EEECCCCCCCCCHHH	41.55	21183079
1241	Phosphorylation	GREERAESSPGLLRR CHHHHHHCCCCHHHH	40.63	28066266
1242	Phosphorylation	REERAESSPGLLRRM HHHHHHCCCCHHHHH	17.94	23608596
1312	Phosphorylation	AIVQKITSPGLKKLA HHHHHHCCCCHHHHH	22.05	28066266
1329	Phosphorylation	VAGAPPGTPRSPALP HHCCCCCCCCCCCCC	22.69	26824392
1332	Phosphorylation	APPGTPRSPALPERR CCCCCCCCCCCCCCC	18.74	26824392
1343	Phosphorylation	PERRPGGSPAGAEEG CCCCCCCCCCCCCCC	19.93	26824392
1362	Phosphorylation	GQMLPAASGADPLCR HHCCCCCCCCCCCCC	36.30	25777480
1383	Phosphorylation	LKGKLLNSKKLSSAA HCCHHHCCCCCCCCC	31.01	25619855
1387	Phosphorylation	LLNSKKLSSAADCPK HHCCCCCCCCCCCCH	27.15	27600695
1400	Phosphorylation	PKAEAFMSPETLPSL CHHHHHCCCCCCCCC	17.09	28066266
1403	Phosphorylation	EAFMSPETLPSLGTA HHHCCCCCCCCCCCC	47.56	28066266
1424	Phosphorylation	SRKGRTGTLGPSKGP CCCCCCCCCCCCCCC	28.12	24719451
1428	Phosphorylation	RTGTLGPSKGPLEKR CCCCCCCCCCCCCCC	48.74	24719451
1451	Phosphorylation	LAPHDRASSTQGGGE ECCCCCCCCCCCCCC	34.51	23737553
1452	Phosphorylation	APHDRASSTQGGGED CCCCCCCCCCCCCCC	24.62	23737553
1453	Phosphorylation	PHDRASSTQGGGEDN CCCCCCCCCCCCCCC	28.83	23737553
1461	Phosphorylation	QGGGEDNSSGGGKKP CCCCCCCCCCCCCCC	42.56	23737553
1462	Phosphorylation	GGGEDNSSGGGKKPK CCCCCCCCCCCCCCC	47.95	23737553
1516	Phosphorylation	LSRGRGKTAHASPCK HHCCCCCCCCCCCCC	26.88	27087446
1520	Phosphorylation	RGKTAHASPCKGRAT CCCCCCCCCCCCCHH	22.44	27087446
1559	Phosphorylation	CKRLRADSRTPAFSP CCCCCCCCCCCCCCC	36.75	26824392
1561	Phosphorylation	RLRADSRTPAFSPFV CCCCCCCCCCCCCCE	23.95	21082442
1754	Phosphorylation	KQGPLRTSARGLSRR HCCCCHHCHHHHHHH	14.99	-
1764	Phosphorylation	GLSRRLQSCYCCDGQ HHHHHCCCCEECCCC	16.20	29899451
1766	Phosphorylation	SRRLQSCYCCDGQGD HHHCCCCEECCCCCC	11.02	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1051	T	Phosphorylation	Kinase	MAPK1	P63085	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAI1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAI1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RAI1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.