WDR26_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR26_MOUSE
• UniProt AC: Q8C6G8
• Protein Name: WD repeat-containing protein 26
• Gene Name: Wdr26
• Organism: Mus musculus (Mouse).
• Sequence Length: 641
• Subcellular Localization: Cytoplasm . Mitochondrion .
• Protein Description: G-beta-like protein involved in cell signal transduction (By similarity). Acts as a negative regulator in MAPK signaling pathway (By similarity). Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes (By similarity). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation (By similarity). Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration (By similarity). Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (By similarity). Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity)..
• Protein Sequence: MQANGAGGGGGGGGGGQGQTPELACLSAQNGESSPSATSAGDLAHANGLLPAAPSAAGNNSNSLSVNNGVPGGAAAASATAAAAQATPELGSSLKKKKRLSQSDEDVIRLIGQHLNGLGLNQTVDLLMQESGCRLEHPSATKFRNHVMEGDWDKAENDLNELKPLVHSPHAIVVRGALEISQTLLGIIVRMKFLLLQQKYLEYLEDGKVLEALQVLRCELTPLKYNTERIHVLSGYLMCSHAEDLRAKAEWEGKGTASRSKLLDKLQTYLPPSVMLPPRRLQTLLRQAVELQRDRCLYHNTKLDNNLDSVSLLIDHVCSRRQFPCYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDDSYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRVRGYNFEDLTDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIWGPAPFIDHQNIEEECSSMDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
101	Phosphorylation	LKKKKRLSQSDEDVI HHHCHHCCCCHHHHH	31.50	27087446
103	Phosphorylation	KKKRLSQSDEDVIRL HCHHCCCCHHHHHHH	39.32	27087446
181	Phosphorylation	VRGALEISQTLLGII EECHHHHHHHHHHHH	14.03	26745281
183	Phosphorylation	GALEISQTLLGIIVR CHHHHHHHHHHHHHH	19.70	26745281
192	Ubiquitination	LGIIVRMKFLLLQQK HHHHHHHHHHHHHHH	23.46	22790023
221	Phosphorylation	QVLRCELTPLKYNTE HHHHCCCCCCCCCHH	12.32	19367708
318	Glutathionylation	SLLIDHVCSRRQFPC HHHHHHHHHHCCCCC	2.05	24333276
318	S-palmitoylation	SLLIDHVCSRRQFPC HHHHHHHHHHCCCCC	2.05	28680068
349	Ubiquitination	KFSNDGTKLATGSKD EECCCCCEECCCCCC	41.47	22790023
439	Ubiquitination	VAWNPDGKRFVTGGQ EEECCCCCCCCCCCC	50.47	22790023
516	Ubiquitination	IMSFTISKNGRLALL EEEEEECCCCEEEEE	60.62	22790023
638	Phosphorylation	NIEEECSSMDS---- CHHHHHHCCCC----	37.96	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR26_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR26_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR26_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of WDR26_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101, AND MASSSPECTROMETRY.
PubMed: 19131326