RABX5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RABX5_MOUSE
• UniProt AC: Q9JM13
• Protein Name: Rab5 GDP/GTP exchange factor
• Gene Name: Rabgef1
• Organism: Mus musculus (Mouse).
• Sequence Length: 491
• Subcellular Localization: Cytoplasm. Early endosome. Recycling endosome.
• Protein Description: Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A (By similarity). Can act as a ubiquitin ligase (By similarity)..
• Protein Sequence: MSLKSERRGIHVDQSELLCKKGCGYYGNPAWQGFCSKCWREEYHKARQRQIQEDWELAERLQREEEEAFASSQSSQGAQSLTFSKFEEKKTNEKTRKVTTVKKFFSASSRAGSKKEIQEAKAPSPSINRQTSIETDRVTKEFIDFLKTFHKTGQEVYKQTKMFLEAMPYKRDLSIEEQSECTQDFYQNVAERMQTRGKVPPEKVEKIMDQIEKHIMTRLYKFVFCPETTDDEKKDLAIQKRIRALHWVTPQMLCVPVNEEIPEVSDMVVKAITDIIEMDSKRVPRDKLACITRCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGNPPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQTSPRKQESESWPPEACLGVKQMYKNLDLLSQLNERQERIMNEAKKLEKDLIDWTDGIAKEVQDIVEKYPLEIKPPNQPLAAIDSENVENDKLPPPLQPQVYAG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Acetylation	----MSLKSERRGIH ----CCCCCCCCCCC	42.85	19850049
85	Ubiquitination	AQSLTFSKFEEKKTN CHHCCCHHHCHHHCC	53.24	22790023
89	Ubiquitination	TFSKFEEKKTNEKTR CCHHHCHHHCCCCCC	58.67	-
103	Ubiquitination	RKVTTVKKFFSASSR CCCHHHHHHHCCCCC	47.51	22790023
106	Phosphorylation	TTVKKFFSASSRAGS HHHHHHHCCCCCCCC	30.30	21454597
108	Phosphorylation	VKKFFSASSRAGSKK HHHHHCCCCCCCCHH	21.11	23375375
109	Phosphorylation	KKFFSASSRAGSKKE HHHHCCCCCCCCHHH	26.35	23375375
113	Phosphorylation	SASSRAGSKKEIQEA CCCCCCCCHHHHHHC	39.30	26824392
121	Ubiquitination	KKEIQEAKAPSPSIN HHHHHHCCCCCCCCC	61.14	27667366
124	Phosphorylation	IQEAKAPSPSINRQT HHHCCCCCCCCCCCC	35.82	27087446
126	Phosphorylation	EAKAPSPSINRQTSI HCCCCCCCCCCCCCC	36.51	25266776
131	Phosphorylation	SPSINRQTSIETDRV CCCCCCCCCCCCHHH	28.56	25521595
132	Phosphorylation	PSINRQTSIETDRVT CCCCCCCCCCCHHHH	15.30	25521595
135	Phosphorylation	NRQTSIETDRVTKEF CCCCCCCCHHHHHHH	27.69	23375375
139	Phosphorylation	SIETDRVTKEFIDFL CCCCHHHHHHHHHHH	26.25	26643407
151	Acetylation	DFLKTFHKTGQEVYK HHHHHHHHHHHHHHH	50.59	-
158	Ubiquitination	KTGQEVYKQTKMFLE HHHHHHHHHHHHHHH	57.58	27667366
159	Ubiquitination	TGQEVYKQTKMFLEA HHHHHHHHHHHHHHH	28.77	27667366
170	Ubiquitination	FLEAMPYKRDLSIEE HHHHCCCCCCCCHHH	33.30	22790023
170	Acetylation	FLEAMPYKRDLSIEE HHHHCCCCCCCCHHH	33.30	-
176	Ubiquitination	YKRDLSIEEQSECTQ CCCCCCHHHHHHHHH	46.75	27667366
177	Ubiquitination	KRDLSIEEQSECTQD CCCCCHHHHHHHHHH	58.71	27667366
206	Acetylation	VPPEKVEKIMDQIEK CCHHHHHHHHHHHHH	46.44	23954790
303	Ubiquitination	KHIFNAIKITKNEPA HHHHHHHHCCCCCCC	41.74	22790023
373	Phosphorylation	IEKLDAQSLNLSQED HHHHCHHHCCCCHHH	22.42	25619855
377	Phosphorylation	DAQSLNLSQEDFDRY CHHHCCCCHHHHHHH	30.37	25619855
384	Phosphorylation	SQEDFDRYMSGQTSP CHHHHHHHHCCCCCC	9.47	25619855
386	Phosphorylation	EDFDRYMSGQTSPRK HHHHHHHCCCCCCCC	20.86	25619855
389	Phosphorylation	DRYMSGQTSPRKQES HHHHCCCCCCCCCCC	44.20	25521595
390	Phosphorylation	RYMSGQTSPRKQESE HHHCCCCCCCCCCCC	18.15	25521595
442	Phosphorylation	EKDLIDWTDGIAKEV HHHHHHHCHHHHHHH	22.17	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RABX5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RABX5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RABX5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RABE1_MOUSE	Rabep1	physical	9524116
GDIB_HUMAN	GDI2	physical	7782346

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.