RHG44_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RHG44_MOUSE
• UniProt AC: Q5SSM3
• Protein Name: Rho GTPase-activating protein 44
• Gene Name: Arhgap44
• Organism: Mus musculus (Mouse).
• Sequence Length: 814
• Subcellular Localization: Cell projection, dendritic spine . Recycling endosome . Cell junction, synapse. In CA1 hippocampal synapses, detected at both presynaptic and postsynaptic sites..
• Protein Description: GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. May act as a GAP for CDC42 and RAC1. Endosomal recycling protein which, in association with SHANK3, is involved in synaptic plasticity. Promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation..
• Protein Sequence: MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEADKRSKKLPLTTLAQCLVEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPSFGKPLEEHLMISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNIQEQDKRLQALWNACEKLPKANHNNIKYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQSEGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNLTGSYGSPVHVNHNANYSSMPSPDMDPADRRQPEQARRPLSVATDNMMLEFYKKDGLRKIQSMGVRVMDTSWVARRGSSAGRKASCAPPSMQPPAPPSELAAPLPSPLPEQVPDSPATPAPALSPSGASLQPTPERPSVSKSKELSPGSGQKGSPGSIQGTPCPGTQLGPQPAASPSQLPADQSPHTLRKVSKKVAPIPPKVPFVQPGTVSDQPVGQPSPVSLSPTPPSTPSPYGLSYPPGYSMASGQLSPASAPPLASPSVFTSTLAKSRPTPKPRQRPTLPPPQPPSVSLSASSPQSTEHPMLDGMSPGESMSTDLVHFDVPSIHIELGSTLRLSPLEHARRHSATDKRDSEEESESTAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
168	Phosphorylation	KSSGLSSSLQPAGAK HHCCCCCCCCCCCHH	27.87	29899451
229	Phosphorylation	QAEYHRKSLTLLQAV HHHHHHHHHHHHHHH	26.92	29899451
309	S-palmitoylation	LKAALDCCVVDVQEY HHHHHCCEEEEHHHH	3.14	28680068
379	Ubiquitination	KANHNNIKYLIKFLS CCCCCCHHHHHHHHH	35.81	22790023
493	Phosphorylation	EQARRPLSVATDNMM HHHCCCCCHHCCCHH	16.64	22817900
496	Phosphorylation	RRPLSVATDNMMLEF CCCCCHHCCCHHEEH	26.25	20415495
514	Phosphorylation	DGLRKIQSMGVRVMD HCHHHHHHCCEEEEE	22.45	22324799
590	Phosphorylation	QPTPERPSVSKSKEL CCCCCCCCCCCCCCC	45.29	23737553
592	Phosphorylation	TPERPSVSKSKELSP CCCCCCCCCCCCCCC	35.23	23737553
598	Phosphorylation	VSKSKELSPGSGQKG CCCCCCCCCCCCCCC	28.45	22324799
601	Phosphorylation	SKELSPGSGQKGSPG CCCCCCCCCCCCCCC	41.24	22817900
606	Phosphorylation	PGSGQKGSPGSIQGT CCCCCCCCCCCCCCC	32.88	19060867
609	Phosphorylation	GQKGSPGSIQGTPCP CCCCCCCCCCCCCCC	18.34	29899451
613	Phosphorylation	SPGSIQGTPCPGTQL CCCCCCCCCCCCCCC	12.82	20415495
627	Phosphorylation	LGPQPAASPSQLPAD CCCCCCCCHHHCCCC	27.47	21659605
629	Phosphorylation	PQPAASPSQLPADQS CCCCCCHHHCCCCCC	41.68	25293948
636	Phosphorylation	SQLPADQSPHTLRKV HHCCCCCCHHHHHHH	21.13	21659605
639	Phosphorylation	PADQSPHTLRKVSKK CCCCCHHHHHHHHHC	31.48	19060867
798	Phosphorylation	LEHARRHSATDKRDS HHHHHHHCCCCCCCC	30.93	29899451
805	Phosphorylation	SATDKRDSEEESEST CCCCCCCCHHHHHHH	51.44	25521595
809	Phosphorylation	KRDSEEESESTAL-- CCCCHHHHHHHCC--	39.88	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RHG44_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RHG44_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RHG44_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RHG44_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.