KIF23_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KIF23_MOUSE
• UniProt AC: E9Q5G3
• Protein Name: Kinesin-like protein KIF23
• Gene Name: Kif23
• Organism: Mus musculus (Mouse).
• Sequence Length: 953
• Subcellular Localization: Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody, Midbody ring . Localizes to the interzone of mitotic spindles (By similarity). Detected at the midbody during later stages of mitotic cytokinesis..
• Protein Description: Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro (By similarity)..
• Protein Sequence: MKSAKAKTVRKPVIKKGSQTNLKDPVGVYCRVRPLSFPDQECCVEVINSTTLQLHTPEGYRLNRNGDYKETQYSFKRVFGTHTTQKELFDVVANPLVDDLIHGKNGLLFTYGVTGSGKTYTMTGSPGSGGLLPRCLNMIFNSIGSFQAKRYVFKSNDRNSMEIQCEVDALLERQKREALPIPKTPSSKRQADPEFADMINVQEFCKAEEVDEDSVYGVFVSYIEIYNNYIYDLLEEVQFDPIKPKLPQSKTLREDKNHNMYVAGCTEVEVKSTEEAFEVFWRGQKKRRIANTHLNRESSRSHSVFSIKLVQAPLDADGDNVLQEKEQITISQLSLVDLAGSERTNRTKAEGNRLREAGNINQSLMTLRTCMEVLRENQTYGTNKMVPYRDSKLTHLFKNYFDGEGKVRMIVCVNPKAEDYEESLQVMRFAEVTQEVEVARPVDKVICGLTPGRRYRNLPRGGPVGDEPLVPEVILQSFPPLPPCKLLDINDEETLPKLADTLEKRHHLRQLMTEDLNKKCLAFKALLKEFDNSLSNKENYVQEKLNEREKVISGQKLEIERLEKKNKTLEYKIEILEKTTTIYEEDKRNLQQELESQNQKLQRQFSDKRRLEARLQGMVTETSMKWQKECERRVAATQLEMQNKLWVKDEKLKQLKAIVTEPKPEKPERPSRERDREKIIPRSVSPSPLPLSSNNIAQISNGQQLMSQPQLHRRSNSCSSISVASCISEWEQKLSPFSTPVNVTSLARHRQQEPGQSKTCIVSDRRRGMCWTEGREMVPTFSSEIGVEEDHCRRNTPIPVRHRRSRSAGSRWVDHKPASNVQTETVMQPHVPHAITVSVANEKALAKCEKYMLTHQELASDGEIQTKVIKGDVYKTRGGGQSVQFTDIETLKQELPTGSRKRRSSTLAPAQPDGTESEWTDVETRCSVAVEMRAGSQLGPGYQHHAQPKRKKP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Acetylation	VRKPVIKKGSQTNLK CCCCCCCCCCCCCCC		2393735
18	Phosphorylation	KPVIKKGSQTNLKDP CCCCCCCCCCCCCCC		29550500
20	Phosphorylation	VIKKGSQTNLKDPVG CCCCCCCCCCCCCCC		29550500
104	Ubiquitination	VDDLIHGKNGLLFTY HHHHHCCCCCEEEEE		-
125	Phosphorylation	KTYTMTGSPGSGGLL CEEEECCCCCCCCCH		22067460
149	Ubiquitination	SIGSFQAKRYVFKSN HCCHHHHEEEEEECC		-
155	Phosphorylation	AKRYVFKSNDRNSME HEEEEEECCCCCCEE		26239621
160	Phosphorylation	FKSNDRNSMEIQCEV EECCCCCCEEEEHHH		27087446
184	Phosphorylation	EALPIPKTPSSKRQA HCCCCCCCCCCCCCC		27600695
186	Phosphorylation	LPIPKTPSSKRQADP CCCCCCCCCCCCCCH		26745281
187	Phosphorylation	PIPKTPSSKRQADPE CCCCCCCCCCCCCHH		26745281
251	Phosphorylation	PKLPQSKTLREDKNH CCCCCCCCCCCCCCC		29514104
298	Phosphorylation	NTHLNRESSRSHSVF CCCCCCHHHCCCCCE		29514104
299	Phosphorylation	THLNRESSRSHSVFS CCCCCHHHCCCCCEE		25338131
382	Phosphorylation	RENQTYGTNKMVPYR HHCCCCCCCCCCCCC		29514104
450	Phosphorylation	DKVICGLTPGRRYRN CEEECCCCCCCCCCC		24453211
501	Phosphorylation	TLPKLADTLEKRHHL HHHHHHHHHHHHHHH		22067460
504	Ubiquitination	KLADTLEKRHHLRQL HHHHHHHHHHHHHHH		-
513	Phosphorylation	HHLRQLMTEDLNKKC HHHHHHHHHHHHHHH		22324799
518	Acetylation	LMTEDLNKKCLAFKA HHHHHHHHHHHHHHH		15618399
528	Ubiquitination	LAFKALLKEFDNSLS HHHHHHHHHHHHHCC		-
540	Phosphorylation	SLSNKENYVQEKLNE HCCCHHHHHHHHHHH		-
544	Acetylation	KENYVQEKLNEREKV HHHHHHHHHHHHHHH		23864654
578	Ubiquitination	YKIEILEKTTTIYEE HHHHHHHHHCCHHHH		-
583	Phosphorylation	LEKTTTIYEEDKRNL HHHHCCHHHHHHHHH		-
587	Ubiquitination	TTIYEEDKRNLQQEL CCHHHHHHHHHHHHH		-
600	Ubiquitination	ELESQNQKLQRQFSD HHHHHHHHHHHHHHH		-
606	Phosphorylation	QKLQRQFSDKRRLEA HHHHHHHHHHHHHHH		29550500
623	Phosphorylation	QGMVTETSMKWQKEC HHHHHHHHHHHHHHH		29514104
671	Phosphorylation	PEKPERPSRERDREK CCCCCCCCCCCHHHH		28066266
683	Phosphorylation	REKIIPRSVSPSPLP HHHCCCCCCCCCCCC		25159016
685	Phosphorylation	KIIPRSVSPSPLPLS HCCCCCCCCCCCCCC		24453211
687	Phosphorylation	IPRSVSPSPLPLSSN CCCCCCCCCCCCCCC		24453211
692	Phosphorylation	SPSPLPLSSNNIAQI CCCCCCCCCCCEEEC		25159016
693	Phosphorylation	PSPLPLSSNNIAQIS CCCCCCCCCCEEECC		25293948
715	Phosphorylation	QPQLHRRSNSCSSIS HHCHHCCCCCCCCCC		26745281
717	Phosphorylation	QLHRRSNSCSSISVA CHHCCCCCCCCCCHH		26745281
719	Phosphorylation	HRRSNSCSSISVASC HCCCCCCCCCCHHHH		26745281
720	O-linked_Glycosylation	RRSNSCSSISVASCI CCCCCCCCCCHHHHH		28528544
720	Phosphorylation	RRSNSCSSISVASCI CCCCCCCCCCHHHHH		26643407
722	Phosphorylation	SNSCSSISVASCISE CCCCCCCCHHHHHHH		25293948
733	Ubiquitination	CISEWEQKLSPFSTP HHHHHHHHHCCCCCC		-
735	Phosphorylation	SEWEQKLSPFSTPVN HHHHHHHCCCCCCCC		23608596
738	Phosphorylation	EQKLSPFSTPVNVTS HHHHCCCCCCCCHHH		28066266
739	Phosphorylation	QKLSPFSTPVNVTSL HHHCCCCCCCCHHHH		-
745	Phosphorylation	STPVNVTSLARHRQQ CCCCCHHHHHHHCCC		29514104
763	Phosphorylation	QSKTCIVSDRRRGMC CCCEEEEECCCCCCC		-
780	Phosphorylation	EGREMVPTFSSEIGV CCCCCCCCCCCCCCC		25293948
782	Phosphorylation	REMVPTFSSEIGVEE CCCCCCCCCCCCCCC		25293948
783	Phosphorylation	EMVPTFSSEIGVEED CCCCCCCCCCCCCCH		25293948
796	Phosphorylation	EDHCRRNTPIPVRHR CHHHCCCCCCCCCCC		22817900
805	Phosphorylation	IPVRHRRSRSAGSRW CCCCCCCCCCCCCCC		-
807	Phosphorylation	VRHRRSRSAGSRWVD CCCCCCCCCCCCCCC		-
860	Phosphorylation	LTHQELASDGEIQTK HHHHHHCCCCCEEEE		26824392
866	Phosphorylation	ASDGEIQTKVIKGDV CCCCCEEEEEEECCE		25159016
882	Phosphorylation	KTRGGGQSVQFTDIE EECCCCCEEEEECHH		28066266
892	Ubiquitination	FTDIETLKQELPTGS EECHHHHHHHCCCCC		-
904	Phosphorylation	TGSRKRRSSTLAPAQ CCCCCCCCCCCCCCC		25168779
905	Phosphorylation	GSRKRRSSTLAPAQP CCCCCCCCCCCCCCC		27087446
906	Phosphorylation	SRKRRSSTLAPAQPD CCCCCCCCCCCCCCC		23429704
915	Phosphorylation	APAQPDGTESEWTDV CCCCCCCCCCCCCCC		21149613
917	Phosphorylation	AQPDGTESEWTDVET CCCCCCCCCCCCCCH		21149613
920	Phosphorylation	DGTESEWTDVETRCS CCCCCCCCCCCHHHE		21149613
924	Phosphorylation	SEWTDVETRCSVAVE CCCCCCCHHHEEEEE		25293948
936	Phosphorylation	AVEMRAGSQLGPGYQ EEEECCCCCCCCCCC		28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
904	S	Phosphorylation	Kinase	PLK1	P53350	PSP
905	S	Phosphorylation	Kinase	PLK1	P53350	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KIF23_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KIF23_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAWR_HUMAN	PAWR	physical	20360068
MIPT3_HUMAN	TRAF3IP1	physical	20360068
SHCBP_HUMAN	SHCBP1	physical	20360068
CD2AP_HUMAN	CD2AP	physical	20360068
IFT20_HUMAN	IFT20	physical	20360068
KIF23_HUMAN	KIF23	physical	20360068
CCAR1_HUMAN	CCAR1	physical	20360068
PHB2_HUMAN	PHB2	physical	20360068
MICA3_HUMAN	MICAL3	physical	20360068
RGAP1_HUMAN	RACGAP1	physical	20360068
RGAP1_HUMAN	RACGAP1	physical	26496610
MICA3_HUMAN	MICAL3	physical	26496610
SHCBP_HUMAN	SHCBP1	physical	26496610
PR14L_HUMAN	PRR14L	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.