TAXB1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAXB1_MOUSE
• UniProt AC: Q3UKC1
• Protein Name: Tax1-binding protein 1 homolog
• Gene Name: Tax1bp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 814
• Protein Description: Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity)..
• Protein Sequence: MTSFQEVQLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHSKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRAASPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTLKEKEELLKLIAVLEKETAQLREQVGRMERELSQEKGRCEQLQAEQKGLLEVSQSLRVENEEFMKRYSDATAKVQQLEEDIVSVTHKAIEKETDLDSLKDKLRKAQHEREQLECQLQTEKDEKELYKVHLKNTEIENTKLVSEIQTLKNLDGNKESMITHFKEEISKLQSCLADKENLYRALLLTTSNKEDTLFLKEQLRKAEEQVQATRQELIFLTKELSDAVNVRDKTMADLHTARLENERVKKQLADTLAELQLHAVKKDQEKTDTLEHELRREVEDLKLRLQMAADHYREKFKECQRLQKQINKLSDQAASTNSVFTKKMGSQQKVNDASINTDPAASTSASAVDVKPAASCAETGFDMSTKDHVCEMTKEIAEKIEKYNKCKQLLQDEKTKCNKYAEELAKMELKWKEQVKIAENVKLELAEVEDNYKVQLAEKEKEINGLASYLENLSREKELTKSLEDQKGRKLEGQSPQQVSRCLNTCSEQNGLLPPLSSAQPVLQYGNPYSAQETRDGADGAFYPDEIQRPPVRVPSWEDNVVCSQPARNLSRPDGLEDPEDSREDENVPIPPDPANQHLRSHGAGFCFDSSFDVHKKCPLCELMFPPNYDQTKFEEHVESHWKVCPMCSEQFPPDYDQQGFERHVQTHFDQNVLNFD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTSFQEVQL ------CCCCCEEEE	37.94	26643407
3	Phosphorylation	-----MTSFQEVQLQ -----CCCCCEEEEH	24.51	26643407
11	Phosphorylation	FQEVQLQTSNFAHVI CCEEEEHHCCCHHHH	33.94	26745281
12	Phosphorylation	QEVQLQTSNFAHVIF CEEEEHHCCCHHHHH	19.59	26745281
124	Phosphorylation	PFQFRAASPVEELLT CCEEEECCCHHHHCC	28.61	21082442
131	Phosphorylation	SPVEELLTMEDEGNS CCHHHHCCCCCCCCC	31.01	23140645
138	Phosphorylation	TMEDEGNSDMLVVTT CCCCCCCCCEEEEEE	34.94	26745281
173	Ubiquitination	KLIAVLEKETAQLRE HHHHHHHHHHHHHHH	57.09	22790023
210	Phosphorylation	QKGLLEVSQSLRVEN HCCHHHHHHHHHCCC	12.50	28066266
212	Phosphorylation	GLLEVSQSLRVENEE CHHHHHHHHHCCCHH	15.61	28066266
222	Acetylation	VENEEFMKRYSDATA CCCHHHHHHHHHHHH	54.21	7614197
225	Phosphorylation	EEFMKRYSDATAKVQ HHHHHHHHHHHHHHH	25.46	28066266
230	Acetylation	RYSDATAKVQQLEED HHHHHHHHHHHHHHH	35.90	7614209
240	Phosphorylation	QLEEDIVSVTHKAIE HHHHHHHHHHHHHHH	22.95	25521595
242	Phosphorylation	EEDIVSVTHKAIEKE HHHHHHHHHHHHHHC	15.34	26745281
244	Ubiquitination	DIVSVTHKAIEKETD HHHHHHHHHHHHCCC	41.51	22790023
254	Phosphorylation	EKETDLDSLKDKLRK HHCCCHHHHHHHHHH	44.61	27742792
288	Ubiquitination	ELYKVHLKNTEIENT HHHHHCCCCCCCCCC	47.12	22790023
305	Ubiquitination	VSEIQTLKNLDGNKE HHHHHHHHCCCCCHH	59.87	22790023
313	Phosphorylation	NLDGNKESMITHFKE CCCCCHHHHHHHHHH	19.66	28066266
316	Phosphorylation	GNKESMITHFKEEIS CCHHHHHHHHHHHHH	16.78	28066266
323	Phosphorylation	THFKEEISKLQSCLA HHHHHHHHHHHHHHC	30.50	15378723
342	Phosphorylation	LYRALLLTTSNKEDT HHHHHHHCCCCHHHC	28.31	30482847
343	Phosphorylation	YRALLLTTSNKEDTL HHHHHHCCCCHHHCH	30.21	30482847
344	Phosphorylation	RALLLTTSNKEDTLF HHHHHCCCCHHHCHH	40.44	30482847
424	Phosphorylation	VKKDQEKTDTLEHEL HHCCHHHHHHHHHHH	33.20	28066266
426	Phosphorylation	KDQEKTDTLEHELRR CCHHHHHHHHHHHHH	39.00	28066266
472	Phosphorylation	KLSDQAASTNSVFTK HHHHHHHHCCHHHHH	31.01	28066266
473	Phosphorylation	LSDQAASTNSVFTKK HHHHHHHCCHHHHHH	27.13	28066266
475	Phosphorylation	DQAASTNSVFTKKMG HHHHHCCHHHHHHCC	20.78	28066266
478	Phosphorylation	ASTNSVFTKKMGSQQ HHCCHHHHHHCCCCC	27.83	28066266
491	Phosphorylation	QQKVNDASINTDPAA CCCCCCCCCCCCCCC	21.16	25619855
494	Phosphorylation	VNDASINTDPAASTS CCCCCCCCCCCCCCC	41.51	25619855
499	Phosphorylation	INTDPAASTSASAVD CCCCCCCCCCCCCCC	25.63	25619855
500	Phosphorylation	NTDPAASTSASAVDV CCCCCCCCCCCCCCC	24.48	25619855
501	Phosphorylation	TDPAASTSASAVDVK CCCCCCCCCCCCCCC	20.10	25619855
503	Phosphorylation	PAASTSASAVDVKPA CCCCCCCCCCCCCCC	28.70	25619855
511	Ubiquitination	AVDVKPAASCAETGF CCCCCCCCHHHHCCC	17.42	27667366
524	Ubiquitination	GFDMSTKDHVCEMTK CCCCCCHHHHHHHHH	39.27	27667366
563	Ubiquitination	KYAEELAKMELKWKE HHHHHHHHCCCCHHH	45.60	22790023
573	Ubiquitination	LKWKEQVKIAENVKL CCHHHHHHHHHHCEE	35.57	27667366
598	Ubiquitination	VQLAEKEKEINGLAS EEHHHHHHHHHHHHH	74.98	22790023
605	Phosphorylation	KEINGLASYLENLSR HHHHHHHHHHHHHHH	34.98	26745281
606	Phosphorylation	EINGLASYLENLSRE HHHHHHHHHHHHHHH	16.66	27717184
617	Phosphorylation	LSREKELTKSLEDQK HHHHHHHHHHHHHHH	21.48	28066266
618	Ubiquitination	SREKELTKSLEDQKG HHHHHHHHHHHHHHC	66.71	22790023
619	Phosphorylation	REKELTKSLEDQKGR HHHHHHHHHHHHHCC	31.58	26824392
627	Ubiquitination	LEDQKGRKLEGQSPQ HHHHHCCCCCCCCHH	60.60	22790023
632	Phosphorylation	GRKLEGQSPQQVSRC CCCCCCCCHHHHHHH	35.22	25521595
637	Phosphorylation	GQSPQQVSRCLNTCS CCCHHHHHHHHHHHH	16.97	26745281
680	Phosphorylation	DGADGAFYPDEIQRP CCCCCCCCCCCCCCC	14.83	23984901
693	Phosphorylation	RPPVRVPSWEDNVVC CCCCCCCCCCCCEEC	39.99	25521595
701	Phosphorylation	WEDNVVCSQPARNLS CCCCEECCCCCCCCC	27.82	26643407
708	Phosphorylation	SQPARNLSRPDGLED CCCCCCCCCCCCCCC	45.37	25266776
719	Phosphorylation	GLEDPEDSREDENVP CCCCCCCCCCCCCCC	35.59	23140645
748	Phosphorylation	AGFCFDSSFDVHKKC CCCCCCCCCCCCCCC	27.58	30482847

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
619	S	Phosphorylation	Kinase	IKKA	Q60680	Uniprot
693	S	Phosphorylation	Kinase	IKKA	Q60680	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAXB1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAXB1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBE2N_MOUSE	Ube2n	physical	20185725
UB2D3_MOUSE	Ube2d3	physical	20185725
TNAP3_MOUSE	Tnfaip3	physical	20185725
IKKA_MOUSE	Chuk	physical	21765415
ITCH_MOUSE	Itch	physical	21765415
TRAF6_MOUSE	Traf6	physical	18239685
RIPK1_MOUSE	Ripk1	physical	18239685

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.