RABE2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RABE2_MOUSE
• UniProt AC: Q91WG2
• Protein Name: Rab GTPase-binding effector protein 2
• Gene Name: Rabep2
• Organism: Mus musculus (Mouse).
• Sequence Length: 554
• Subcellular Localization: Cytoplasm. Early endosome.
• Protein Description: Plays a role in membrane trafficking and in homotypic early endosome fusion..
• Protein Sequence: MAAAPATLALDPQPQEKQKDASESSELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYETQIAALKQERQQQQQDFEEKDRELGHLKQLLARAHPLDSLEKQMEKAHEDSEKLREIVLPMEQEITELKGKLQRAEELIQEIQRRPRQPASLHGSTELLPLSRNPSPPLEPLEEPSGDAGPAAEAFAHNCDDSASISSFSLGGAAGSASLRGPQGLSPEQEETASLVSTGTLVPEGIFLPPPGYQLVPDSQWEQLQVEGRQLQKELESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELATSHKCLSQEVKRLNEENQGLRAEQLPSSALQGSEQREDQDEALPSSIQELHLLVQNTRQQARARQQAQEHEAERLRIEIVKLREALDEETAAKASLERQLRVQREETDVLEASLCSLRIETERVQQEQRKAQLTDLLSEQRAKTLRLQAELETSEQVQRDFVRLSQALQVRLERIRQAETLQQVRSILDEAPLRDIRDIKDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	GALAEMETMKAVAEV HHHHHHHHHHHHHHH	23.74	28066266
51	Phosphorylation	MKAVAEVSESTKAEA HHHHHHHCHHHHHHH	19.82	28066266
53	Phosphorylation	AVAEVSESTKAEAVA HHHHHCHHHHHHHHH	27.92	28066266
54	Phosphorylation	VAEVSESTKAEAVAA HHHHCHHHHHHHHHH	30.17	28066266
92	Ubiquitination	ETQIAALKQERQQQQ HHHHHHHHHHHHHHH	45.44	27667366
176	Phosphorylation	RRPRQPASLHGSTEL HCCCCCCCCCCCCCC	27.81	27087446
180	Phosphorylation	QPASLHGSTELLPLS CCCCCCCCCCCEECC	14.15	27087446
181	Phosphorylation	PASLHGSTELLPLSR CCCCCCCCCCEECCC	34.93	27087446
187	Phosphorylation	STELLPLSRNPSPPL CCCCEECCCCCCCCC	28.24	20469934
191	Phosphorylation	LPLSRNPSPPLEPLE EECCCCCCCCCCCCC	42.57	23649490
201	Phosphorylation	LEPLEEPSGDAGPAA CCCCCCCCCCCCHHH	53.22	25293948
218	Phosphorylation	FAHNCDDSASISSFS HHHCCCCCCCCCCEE	15.63	25293948
220	Phosphorylation	HNCDDSASISSFSLG HCCCCCCCCCCEECC	27.27	25293948
222	Phosphorylation	CDDSASISSFSLGGA CCCCCCCCCEECCCC	23.88	25293948
223	Phosphorylation	DDSASISSFSLGGAA CCCCCCCCEECCCCC	19.72	25293948
225	Phosphorylation	SASISSFSLGGAAGS CCCCCCEECCCCCCC	28.22	25293948
232	Phosphorylation	SLGGAAGSASLRGPQ ECCCCCCCHHHCCCC	15.23	25293948
234	Phosphorylation	GGAAGSASLRGPQGL CCCCCCHHHCCCCCC	21.94	25293948
248	Phosphorylation	LSPEQEETASLVSTG CCHHHHHHHHHHCCC	22.31	23649490
359	Phosphorylation	ATSHKCLSQEVKRLN HHHHHHHHHHHHHHH	33.49	18779572

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RABE2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RABE2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RABE2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MRCKA_HUMAN	CDC42BPA	physical	26496610
ELMO3_HUMAN	ELMO3	physical	26496610
KCTD7_HUMAN	KCTD7	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.