LETM1_MOUSE - dbPTM
LETM1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LETM1_MOUSE
UniProt AC Q9Z2I0
Protein Name Mitochondrial proton/calcium exchanger protein {ECO:0000305}
Gene Name Letm1 {ECO:0000312|MGI:MGI:1932557}
Organism Mus musculus (Mouse).
Sequence Length 738
Subcellular Localization Mitochondrion inner membrane
Single-pass membrane protein .
Protein Description Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion. [PubMed: 27669901 Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity Required for the maintenance of the tubular shape and cristae organization (By similarity In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (By similarity]
Protein Sequence MASILLRSCRGRGPARLAPPRAASPRGSLRDRACLSCTRTLGLTSRESVLSRCCTPAHPVYLCFKGEPLSCWTQRPECQGTAARTTWTPASARLVVTGPQYLPVRGWHSSSPLGEDSVIEKSLKSLKDKNKKLEEGGPVYSPPAQVVVRKSLGQKVLDELRHYYHGFRLLWIDTKIAARMLWRILNGHTLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVVVKLFPNMLPSTFETQSIKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGNATKDFSAFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLISEEGVDSLTVKELQAACRARGMRALGVTEDRLKGQLKQWLDLHLHHEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEKVDNKAKLEATLQEEAAIQQEHLEELKRASEAVKDIQPEVAEATLPGRPGPEPQPPVDDVILPSEVLTDTAPVLEGLKGEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYIEESAASKRLSKRVQQMIGQIDGLITQLETTQQDGKLGPSQSTPTGESVISITELISAMKQIKHIPEHKLISLTSALDDNKDGNINIDDLVKVIDLVNKEDVQISTTQVAEIVATLEKEEKIEEKEKAKEKAEKEAAEVKN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MASILLRSCR
-----CCHHHHHHCC		16.6921183079
36PhosphorylationLRDRACLSCTRTLGL
HHHHHHHHCCCCCCC		17.2122817900
44PhosphorylationCTRTLGLTSRESVLS
CCCCCCCCCHHHHHH		24.7622817900
125PhosphorylationVIEKSLKSLKDKNKK
HHHHHHHHHHHHCCC		46.0429176673
189PhosphorylationWRILNGHTLTRRERR
HHHHCCCCCCHHHHH		31.09-
283AcetylationAAKGNATKDFSAFFQ
HHCCCCCHHHHHHHH		55.1323201123
291UbiquitinationDFSAFFQKIRETGER
HHHHHHHHHHHHCCC		38.2822790023
291AcetylationDFSAFFQKIRETGER
HHHHHHHHHHHHCCC		38.2823201123
329S-nitrosocysteineRPQLVALCKLLELQS
HHHHHHHHHHHHHHH		1.79-
329S-palmitoylationRPQLVALCKLLELQS
HHHHHHHHHHHHHHH		1.7928680068
329S-nitrosylationRPQLVALCKLLELQS
HHHHHHHHHHHHHHH		1.7921278135
329GlutathionylationRPQLVALCKLLELQS
HHHHHHHHHHHHHHH		1.7924333276
458AcetylationVAEVEGEKVDNKAKL
EEEEECCCCCCHHHH		66.7923576753
484AcetylationQEHLEELKRASEAVK
HHHHHHHHHHHHHHH		49.552395467
548PhosphorylationKEEIDILSDACSKLQ
HHHHHHHHHHHHHHH		24.4026525534
563AcetylationEQKKSLTKEKEELEL
HHHHHCHHHHHHHHH		72.5719856841
565AcetylationKKSLTKEKEELELLK
HHHCHHHHHHHHHHH		59.0323954790
586AcetylationSEDLQEIKKELSKTG
HHHHHHHHHHHHHHC		39.1723864654
596AcetylationLSKTGEEKYIEESAA
HHHHCCHHHHHHHHH		47.4223201123
605AcetylationIEESAASKRLSKRVQ
HHHHHHHHHHHHHHH		53.2723576753
639PhosphorylationGKLGPSQSTPTGESV
CCCCCCCCCCCCCCH		40.4623140645
640PhosphorylationKLGPSQSTPTGESVI
CCCCCCCCCCCCCHH		19.7523140645
642PhosphorylationGPSQSTPTGESVISI
CCCCCCCCCCCHHCH		54.3823140645
645PhosphorylationQSTPTGESVISITEL
CCCCCCCCHHCHHHH		26.5423140645
648PhosphorylationPTGESVISITELISA
CCCCCHHCHHHHHHH		22.6923140645
650PhosphorylationGESVISITELISAMK
CCCHHCHHHHHHHHH		20.2523140645
660AcetylationISAMKQIKHIPEHKL
HHHHHHCCCCCHHHE		32.7523201123
678AcetylationTSALDDNKDGNINID
HHCCCCCCCCCCCHH		74.2023954790
715UbiquitinationEIVATLEKEEKIEEK
HHHHHHHHHHHHHHH		74.43-
722AcetylationKEEKIEEKEKAKEKA
HHHHHHHHHHHHHHH		52.2923201123
737AcetylationEKEAAEVKN------
HHHHHHHCC------		48.742395483
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LETM1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LETM1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LETM1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of LETM1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LETM1_MOUSE

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Related Literatures of Post-Translational Modification

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