DAPLE_MOUSE - dbPTM
DAPLE_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DAPLE_MOUSE
UniProt AC Q6VGS5
Protein Name Protein Daple
Gene Name Ccdc88c
Organism Mus musculus (Mouse).
Sequence Length 2009
Subcellular Localization Cytoplasm .
Protein Description Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization. [PubMed: 14750955 May also activate the JNK signaling pathway (By similarity]
Protein Sequence MDVTVSQLVELFLQSPLVTWVKTFGSFGSGHQDNLTLYMDLVDGIFLNQIMLQIDPRPSNQRINKHVNNDVNLRIQNLSILVRNIKTYYQEVLQQLIVMNLPNVLMIGKDPLSGKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLDLPDVAPEELEALSRNMVFHLRRLIDERDECTELIVDLTQERDYLQTQQPPSPGKFSSPDSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARAYRDELDSLREKANRVERLEMDLVRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTASRARSDKVHELEKENLQLKSKLHDLELDRDADKKQIEKLLEEYMVLEMAQKQSMKESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDTSLALEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQIKDLEQEKGHLHQAVWSLRERPQVNSTKDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEKGEQAEALEKELHRLEKENEQLTKEVTSLKAATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLEGLERDKQQLGQENLELRKMVEAMRFTSAKMAQIETENRQLEREKEELRRDVELLKTLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAAEKESRALDKELARCRDVGSKLKELEKDNRDLTKQVTMHTRTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLSKDLLLQEDDGHGDGKGKTESALKTTLAMKEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRQTQEGGDKAQNALKRPPGKVTSHQEKEAWEPSHKEATMELLRVKDRAIELERSNAALQAERQLLKEQLQHLETQNVSFSSQILTLQKQSAFLQEHTTTLQTQTAKLQVENSTLSSQNAALSAQYTVLQSQQAAKEAEHEGLQQQQEQLAAVYEALLQDHKHLGTLYECQSSEYEALIRQHSCLKTLHRNLELEHKELGERHGDLQQRKAELEELEKVLSTEREALEREQKTNAIATSENQRLRGELDRISFLHQQLKGEYEELHAHTKELKTSLNNSQLELSRWQVRFDELKEQHQSMDISLTKMDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMESKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKFYDPAPKKKNHWIGAKALVKLIKPKKEGSRERLKSTTDSPPWQLEPSDPASPSPSQALRSQTENPDNPPSGPNCVEERDTHNGPVGKGPGDLKPKRGSPRGGSVDRTDTSTDPAVKSWPSEPGSRTFSTSATTAALSSSTPIPKHLGRTKGCNSDDNLCEPSSEPDGPYHRQQASRPNSLESSRNASSNSSPLSLKGSSDHLHSRCESFSSADLIPSRDPATLSRDGNTSGRGLLGRHEYPPPRNGPVSQETIQKKGAASTHTGVRPHSASPSSEMVTLEEFLEESNRGGSPTHDTPSCRDDLLSDYFRKAHDPPALGGQPGPPARKDGAKMPTSFVAPTIKMSINTSEGQQLKPGHYVKPNLRPSEAEALAGMPSRQVQPPQSLSLGRPRQTTMTQNCHMPVSRSASLSRAFSLASADLLRASGPEACRPESPQKPGGHEAAGARETSTHSLQGSHILARERTPIVGKADSPSPGQGTRGRPLDTRRFSLAPPKEERLAPLQQSATAPALATGCSSGSNPQIQHFSPTVAPAVRTKSKVPQHSGEVATVAPVRPGLGTSEGDGGPGHGYSEGLLTKSPGRSSDLPPHVKRGPDDFSQGSSSKSTPASPEPGGDPQTVWYEYGCV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
219PhosphorylationDLTQERDYLQTQQPP
HHHHHHHHHHCCCCC		13.6128285833
222PhosphorylationQERDYLQTQQPPSPG
HHHHHHHCCCCCCCC		26.9529472430
227PhosphorylationLQTQQPPSPGKFSSP
HHCCCCCCCCCCCCC		53.6324899341
233PhosphorylationPSPGKFSSPDSTPSP
CCCCCCCCCCCCCCC		35.5428973931
237PhosphorylationKFSSPDSTPSPTSSL
CCCCCCCCCCCCCCC		34.8625521595
239PhosphorylationSSPDSTPSPTSSLSS
CCCCCCCCCCCCCCH		40.6826239621
246PhosphorylationSPTSSLSSEDKQHLA
CCCCCCCHHHHHHHH		55.9225521595
440PhosphorylationGWELEQLSKNADLSD
HHHHHHHHCCCCCCH		24.4526239621
486PhosphorylationIQGLRDTSLALEESS
HHHHHHHHHHHHHHH		18.88-
665PhosphorylationVEALEHQSQGLELEN
HHHHHHHHHHHHHCC		28.2921454597
787PhosphorylationQALQRELSQLEAERQ
HHHHHHHHHHHHHHH		28.1521743459
866PhosphorylationLSAAEKESRALDKEL
HHHHHHHHHHHHHHH		33.6422324799
922PhosphorylationKLKSQQLSSELDKLS
HHHHHHHHHHHHHHH		19.8926824392
1017UbiquitinationDKAQNALKRPPGKVT
HHHHHHHCCCCCCCC		61.52-
1022UbiquitinationALKRPPGKVTSHQEK
HHCCCCCCCCCHHHH		48.38-
1108AcetylationTLQTQTAKLQVENST
HHHHHHEEEEEECCC		42.722390229
1419PhosphorylationGSRERLKSTTDSPPW
CCHHHHHCCCCCCCC		40.9225266776
1420PhosphorylationSRERLKSTTDSPPWQ
CHHHHHCCCCCCCCC		32.7925266776
1421PhosphorylationRERLKSTTDSPPWQL
HHHHHCCCCCCCCCC		41.3825266776
1435PhosphorylationLEPSDPASPSPSQAL
CCCCCCCCCCHHHHH		31.16-
1482PhosphorylationDLKPKRGSPRGGSVD
CCCCCCCCCCCCCCC		18.5623375375
1487PhosphorylationRGSPRGGSVDRTDTS
CCCCCCCCCCCCCCC		24.5423375375
1491PhosphorylationRGGSVDRTDTSTDPA
CCCCCCCCCCCCCCC		38.8829899451
1538PhosphorylationGRTKGCNSDDNLCEP
CCCCCCCCCCCCCCC		50.8729899451
1575PhosphorylationRNASSNSSPLSLKGS
CCCCCCCCCCCCCCC		33.8322006019
1582PhosphorylationSPLSLKGSSDHLHSR
CCCCCCCCCHHHHHC		30.8828507225
1592PhosphorylationHLHSRCESFSSADLI
HHHHCCCCCCCCCCC		33.77-
1675PhosphorylationEESNRGGSPTHDTPS
HHHCCCCCCCCCCCC		29.4628066266
1677PhosphorylationSNRGGSPTHDTPSCR
HCCCCCCCCCCCCHH		33.8028066266
1680PhosphorylationGGSPTHDTPSCRDDL
CCCCCCCCCCHHHHH		14.9728066266
1790PhosphorylationCHMPVSRSASLSRAF
CCCCCCCCHHHHHHH		18.0721930439
1794PhosphorylationVSRSASLSRAFSLAS
CCCCHHHHHHHHHHH		21.0421930439
1798PhosphorylationASLSRAFSLASADLL
HHHHHHHHHHHHHHH		23.2626239621
1801PhosphorylationSRAFSLASADLLRAS
HHHHHHHHHHHHHHH		27.8421930439
1808PhosphorylationSADLLRASGPEACRP
HHHHHHHHCCCCCCC		48.7421930439
1817PhosphorylationPEACRPESPQKPGGH
CCCCCCCCCCCCCCC		35.0029899451
1848PhosphorylationHILARERTPIVGKAD
EEEEECCCCCCCCCC		16.7723737553
1856PhosphorylationPIVGKADSPSPGQGT
CCCCCCCCCCCCCCC		31.9423737553
1858PhosphorylationVGKADSPSPGQGTRG
CCCCCCCCCCCCCCC		45.6923737553
1863PhosphorylationSPSPGQGTRGRPLDT
CCCCCCCCCCCCCCC		23.2823737553
1874PhosphorylationPLDTRRFSLAPPKEE
CCCCCCCCCCCCHHH		23.0829899451
1992PhosphorylationSSKSTPASPEPGGDP
CCCCCCCCCCCCCCC		30.8823384938
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DAPLE_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DAPLE_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DAPLE_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of DAPLE_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DAPLE_MOUSE

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Related Literatures of Post-Translational Modification

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