dbPTM

PHLB2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PHLB2_MOUSE
UniProt AC	Q8K1N2
Protein Name	Pleckstrin homology-like domain family B member 2
Gene Name	Phldb2
Organism	Mus musculus (Mouse).
Sequence Length	1249
Subcellular Localization	Cytoplasm. Membrane Peripheral membrane protein. Translocates to the plasma membrane at high levels of PtdIns(3,4,5)P3. At low levels of PtdIns(3,4,5)P3 is translocated to vesicular compartments (By similarity)..
Protein Description	Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane..
Protein Sequence	MAEDSHMQKQLEFQNGSLEEGFVVRSLENEPQNMMESLSPRKYSSSLKFKANGDYSGSYLTLSQPVSAKRSPSPMGTSVRSSPSLAKIQGSKQFCDGIDKNISMKPPISFLSSAASLGGYPLGKADLDHYTGRDSERSTRLSEKPPYSRYSSRNKSHDSVYFLGGLEGRKTSGSLLTMWNGNSLSCTGSSPISRSGAASMPSSPKQVRKMNLQDHSTLQPRLSRHKEPASENVSVRTRKYSGSSLSNMGAYSRSLPRLYKATDNQMSPLSLPPRSSLGNSRRGQLGEKDLPHSLVDSDNYLNFSSLSSGASPYKTCLSEGNPYVSSALSVPASPRVARKMLLASTSSDDFDRASYSGTSPSHSFISGEPDRVLVARRNFSCGSMELDDSDLESLRQSSETPQPVLRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPEGRRLSAGTTVADVQKINKELEKLQLSDEESVFEDALVCPDARYRCHRKGSLQDVDVAGFGNLGHSASFLAPRGSRSDELLGDLTRTPPSSSAAFLKATNESSYLSILPKTPEDIGEEQRTQELAAMEDARMVILNNLEELEQKIKDINDQMDESSRELDMECALLDGEQKSETAELMKEKEILDHLNRKITELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVARKEKISALKKQASHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLTGGKGFPINPNTLKEGYISVNEINESCGNSTNLSPSTQFPADADAAVTEPALAVPVSQPQSSEHFRSLEERKKQHKEGLYLSDTLPRKKTTPSLSPHFSSATMGRSTTPKAHLPLGQSNSCGSVLPHSLATMTKDSESRRMLRGYNHQQMSEGQRQKPEFYSRTASESNVYLNSFHYPDRSYKDQAYDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIREKQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCFHVSITEKTCRGYLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHEAKLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	QLEFQNGSLEEGFVV HHHHCCCCCCCCEEE	39.91	29514104
37	Phosphorylation	EPQNMMESLSPRKYS CCCHHHHHCCCCCCC	19.09	25777480
39	Phosphorylation	QNMMESLSPRKYSSS CHHHHHCCCCCCCCC	31.75	26239621
44	Phosphorylation	SLSPRKYSSSLKFKA HCCCCCCCCCCEEEE	19.24	18779572
45	Phosphorylation	LSPRKYSSSLKFKAN CCCCCCCCCCEEEEC	36.28	18779572
46	Phosphorylation	SPRKYSSSLKFKANG CCCCCCCCCEEEECC	29.64	20450229
55	Phosphorylation	KFKANGDYSGSYLTL EEEECCCCCCCEEEE	19.14	29514104
59	Phosphorylation	NGDYSGSYLTLSQPV CCCCCCCEEEECCCC	13.77	29514104
71	Phosphorylation	QPVSAKRSPSPMGTS CCCCCCCCCCCCCCC	29.08	21659605
73	Phosphorylation	VSAKRSPSPMGTSVR CCCCCCCCCCCCCCC	28.85	27087446
77	Phosphorylation	RSPSPMGTSVRSSPS CCCCCCCCCCCCCCH	20.14	29472430
78	Phosphorylation	SPSPMGTSVRSSPSL CCCCCCCCCCCCCHH	15.14	26643407
81	Phosphorylation	PMGTSVRSSPSLAKI CCCCCCCCCCHHHHH	44.43	26643407
82	Phosphorylation	MGTSVRSSPSLAKIQ CCCCCCCCCHHHHHC	14.14	27149854
84	Phosphorylation	TSVRSSPSLAKIQGS CCCCCCCHHHHHCCC	42.79	27149854
103	Phosphorylation	DGIDKNISMKPPISF CCCCCCCCCCCCHHH	30.10	26239621
109	Phosphorylation	ISMKPPISFLSSAAS CCCCCCHHHHHCCHH	26.38	26239621
112	Phosphorylation	KPPISFLSSAASLGG CCCHHHHHCCHHHCC	18.87	26239621
113	Phosphorylation	PPISFLSSAASLGGY CCHHHHHCCHHHCCC	29.96	26239621
116	Phosphorylation	SFLSSAASLGGYPLG HHHHCCHHHCCCCCC	27.54	26239621
130	Phosphorylation	GKADLDHYTGRDSER CCCCHHCCCCCCCHH	15.57	18563927
147	Phosphorylation	RLSEKPPYSRYSSRN CCCCCCCCCCCCCCC	17.82	29514104
148	Phosphorylation	LSEKPPYSRYSSRNK CCCCCCCCCCCCCCC	30.43	26643407
150	Phosphorylation	EKPPYSRYSSRNKSH CCCCCCCCCCCCCCC	12.69	26643407
151	Phosphorylation	KPPYSRYSSRNKSHD CCCCCCCCCCCCCCC	23.01	26643407
152	Phosphorylation	PPYSRYSSRNKSHDS CCCCCCCCCCCCCCE	30.82	26643407
156	Phosphorylation	RYSSRNKSHDSVYFL CCCCCCCCCCEEEEE	35.76	27087446
159	Phosphorylation	SRNKSHDSVYFLGGL CCCCCCCEEEEECCC	17.19	26824392
161	Phosphorylation	NKSHDSVYFLGGLEG CCCCCEEEEECCCCC	9.31	26239621
171	Phosphorylation	GGLEGRKTSGSLLTM CCCCCCCCCCCEEEE	36.64	26643407
172	Phosphorylation	GLEGRKTSGSLLTMW CCCCCCCCCCEEEEE	29.44	26643407
174	Phosphorylation	EGRKTSGSLLTMWNG CCCCCCCCEEEEECC	21.70	26643407
189	Phosphorylation	NSLSCTGSSPISRSG CCCEEECCCCCCCCC	18.13	26643407
190	Phosphorylation	SLSCTGSSPISRSGA CCEEECCCCCCCCCC	27.83	26643407
193	Phosphorylation	CTGSSPISRSGAASM EECCCCCCCCCCCCC	24.63	26643407
195	Phosphorylation	GSSPISRSGAASMPS CCCCCCCCCCCCCCC	26.45	26160508
199	Phosphorylation	ISRSGAASMPSSPKQ CCCCCCCCCCCCHHH	30.60	27087446
202	Phosphorylation	SGAASMPSSPKQVRK CCCCCCCCCHHHHHH	51.10	27087446
203	Phosphorylation	GAASMPSSPKQVRKM CCCCCCCCHHHHHHC	30.19	25521595
216	Phosphorylation	KMNLQDHSTLQPRLS HCCCCCCCCCCHHHH	38.82	24719451
217	Phosphorylation	MNLQDHSTLQPRLSR CCCCCCCCCCHHHHC	26.45	26824392
223	Phosphorylation	STLQPRLSRHKEPAS CCCCHHHHCCCCCCC	33.35	26643407
234	Phosphorylation	EPASENVSVRTRKYS CCCCCCCEEEEEECC	19.91	26824392
237	Phosphorylation	SENVSVRTRKYSGSS CCCCEEEEEECCCCC	29.38	26643407
240	Phosphorylation	VSVRTRKYSGSSLSN CEEEEEECCCCCHHH	18.25	26239621
241	Phosphorylation	SVRTRKYSGSSLSNM EEEEEECCCCCHHHH	34.92	25521595
243	Phosphorylation	RTRKYSGSSLSNMGA EEEECCCCCHHHHCC	23.36	27087446
244	Phosphorylation	TRKYSGSSLSNMGAY EEECCCCCHHHHCCC	39.07	21082442
246	Phosphorylation	KYSGSSLSNMGAYSR ECCCCCHHHHCCCCC	27.07	26239621
251	Phosphorylation	SLSNMGAYSRSLPRL CHHHHCCCCCCCCCE	10.01	23984901
252	Phosphorylation	LSNMGAYSRSLPRLY HHHHCCCCCCCCCEE	18.17	25159016
254	Phosphorylation	NMGAYSRSLPRLYKA HHCCCCCCCCCEEEC	36.46	25159016
280	Phosphorylation	PRSSLGNSRRGQLGE CCHHCCCCCCCCCCC	22.89	28059163
293	Phosphorylation	GEKDLPHSLVDSDNY CCCCCCCCCCCCCCC	28.31	26643407
297	Phosphorylation	LPHSLVDSDNYLNFS CCCCCCCCCCCCCHH	21.92	26239621
300	Phosphorylation	SLVDSDNYLNFSSLS CCCCCCCCCCHHHCC	14.17	26643407
304	Phosphorylation	SDNYLNFSSLSSGAS CCCCCCHHHCCCCCC	29.33	26239621
305	Phosphorylation	DNYLNFSSLSSGASP CCCCCHHHCCCCCCC	28.29	26643407
307	Phosphorylation	YLNFSSLSSGASPYK CCCHHHCCCCCCCCC	28.77	26239621
308	Phosphorylation	LNFSSLSSGASPYKT CCHHHCCCCCCCCCC	43.61	26239621
311	Phosphorylation	SSLSSGASPYKTCLS HHCCCCCCCCCCCCC	32.08	26239621
313	Phosphorylation	LSSGASPYKTCLSEG CCCCCCCCCCCCCCC	19.21	23984901
315	Phosphorylation	SGASPYKTCLSEGNP CCCCCCCCCCCCCCC	16.91	25619855
318	Phosphorylation	SPYKTCLSEGNPYVS CCCCCCCCCCCCCCC	45.67	25619855
323	Phosphorylation	CLSEGNPYVSSALSV CCCCCCCCCCCCCCC	19.57	25619855
325	Phosphorylation	SEGNPYVSSALSVPA CCCCCCCCCCCCCCC	12.21	25619855
326	Phosphorylation	EGNPYVSSALSVPAS CCCCCCCCCCCCCCC	24.16	25619855
329	Phosphorylation	PYVSSALSVPASPRV CCCCCCCCCCCCHHH	26.27	27087446
333	Phosphorylation	SALSVPASPRVARKM CCCCCCCCHHHHHHH	13.73	25521595
344	Phosphorylation	ARKMLLASTSSDDFD HHHHHHHCCCCCCCC	28.88	26824392
345	Phosphorylation	RKMLLASTSSDDFDR HHHHHHCCCCCCCCC	27.00	25168779
346	Phosphorylation	KMLLASTSSDDFDRA HHHHHCCCCCCCCCH	29.31	25521595
347	Phosphorylation	MLLASTSSDDFDRAS HHHHCCCCCCCCCHH	41.09	25521595
354	Phosphorylation	SDDFDRASYSGTSPS CCCCCCHHCCCCCCC	22.26	26239621
355	Phosphorylation	DDFDRASYSGTSPSH CCCCCHHCCCCCCCC	15.33	25619855
356	Phosphorylation	DFDRASYSGTSPSHS CCCCHHCCCCCCCCC	32.85	25619855
358	Phosphorylation	DRASYSGTSPSHSFI CCHHCCCCCCCCCCC	31.37	26824392
359	Phosphorylation	RASYSGTSPSHSFIS CHHCCCCCCCCCCCC	28.12	26824392
361	Phosphorylation	SYSGTSPSHSFISGE HCCCCCCCCCCCCCC	31.37	23684622
363	Phosphorylation	SGTSPSHSFISGEPD CCCCCCCCCCCCCCC	28.72	23684622
366	Phosphorylation	SPSHSFISGEPDRVL CCCCCCCCCCCCEEE	34.78	25619855
380	Phosphorylation	LVARRNFSCGSMELD EEEECCCCCCCCCCC	22.55	25521595
383	Phosphorylation	RRNFSCGSMELDDSD ECCCCCCCCCCCHHH	17.26	27087446
389	Phosphorylation	GSMELDDSDLESLRQ CCCCCCHHHHHHHHH	43.70	26824392
393	Phosphorylation	LDDSDLESLRQSSET CCHHHHHHHHHCCCC	35.83	25619855
397	Phosphorylation	DLESLRQSSETPQPV HHHHHHHCCCCCCHH	24.57	26643407
398	Phosphorylation	LESLRQSSETPQPVL HHHHHHCCCCCCHHH	36.83	26643407
400	Phosphorylation	SLRQSSETPQPVLRE HHHHCCCCCCHHHHH	29.22	25521595
410	Phosphorylation	PVLRERKSSISSISG HHHHHCHHHCHHCCC	38.84	21082442
411	Phosphorylation	VLRERKSSISSISGR HHHHCHHHCHHCCCC	29.53	27087446
413	Phosphorylation	RERKSSISSISGRDD HHCHHHCHHCCCCHH	24.46	26824392
414	Phosphorylation	ERKSSISSISGRDDL HCHHHCHHCCCCHHH	21.07	27087446
416	Phosphorylation	KSSISSISGRDDLMD HHHCHHCCCCHHHHH	29.71	27087446
465	Phosphorylation	KPEGRRLSAGTTVAD CCCCCCCCCCCCHHH	23.88	25521595
468	Phosphorylation	GRRLSAGTTVADVQK CCCCCCCCCHHHHHH	20.15	25619855
469	Phosphorylation	RRLSAGTTVADVQKI CCCCCCCCHHHHHHH	16.87	25619855
486	Phosphorylation	ELEKLQLSDEESVFE HHHHCCCCCCCCHHC	29.98	27087446
490	Phosphorylation	LQLSDEESVFEDALV CCCCCCCCHHCCCCC	30.02	27087446
510	Phosphorylation	YRCHRKGSLQDVDVA HHHCCCCCCCCEEEC	26.37	25521595
525	Phosphorylation	GFGNLGHSASFLAPR CCCCCCCCHHCCCCC	24.66	26824392
527	Phosphorylation	GNLGHSASFLAPRGS CCCCCCHHCCCCCCC	24.65	26824392
534	Phosphorylation	SFLAPRGSRSDELLG HCCCCCCCCCHHHCC	29.86	25521595
536	Phosphorylation	LAPRGSRSDELLGDL CCCCCCCCHHHCCCC	36.81	25521595
544	Phosphorylation	DELLGDLTRTPPSSS HHHCCCCCCCCCCCH	36.92	25619855
546	Phosphorylation	LLGDLTRTPPSSSAA HCCCCCCCCCCCHHH	34.02	25521595
549	Phosphorylation	DLTRTPPSSSAAFLK CCCCCCCCCHHHHHH	37.82	25619855
550	Phosphorylation	LTRTPPSSSAAFLKA CCCCCCCCHHHHHHH	29.75	25619855
551	Phosphorylation	TRTPPSSSAAFLKAT CCCCCCCHHHHHHHC	28.14	25619855
558	Phosphorylation	SAAFLKATNESSYLS HHHHHHHCCCCCCEE	37.62	23984901
561	Phosphorylation	FLKATNESSYLSILP HHHHCCCCCCEECCC	26.76	23984901
562	Phosphorylation	LKATNESSYLSILPK HHHCCCCCCEECCCC	24.74	23984901
563	Phosphorylation	KATNESSYLSILPKT HHCCCCCCEECCCCC	17.47	25777480
565	Phosphorylation	TNESSYLSILPKTPE CCCCCCEECCCCCHH	17.53	23984901
570	Phosphorylation	YLSILPKTPEDIGEE CEECCCCCHHHCCHH	29.94	26824392
580	Phosphorylation	DIGEEQRTQELAAME HCCHHHHHHHHHHHH	26.53	23984901
655	Ubiquitination	RKITELEKNIVGEKT HHHHHHHHHCCCHHH	65.68	22790023
655 (in isoform 2)	Ubiquitination	-	65.68	22790023
686	Ubiquitination	QELYSEQKTQLDNCP HHHHHHHHHHHHCCC	33.90	22790023
686 (in isoform 2)	Ubiquitination	-	33.90	22790023
715	Phosphorylation	ADLLDVESKHFEDLE HHHHCHHHHHHHCHH	31.14	29514104
716	Ubiquitination	DLLDVESKHFEDLEF HHHCHHHHHHHCHHH	38.52	22790023
716 (in isoform 2)	Ubiquitination	-	38.52	22790023
736	Ubiquitination	ESRLDEEKENLTQQL HHHHHHHHHHHHHHH	50.26	22790023
736 (in isoform 2)	Ubiquitination	-	50.26	22790023
769	Phosphorylation	SALKKQASHIVQQAQ HHHHHHHHHHHHHHH	15.97	25338131
808	Phosphorylation	CNLEKKYSSLTGGKG CCHHHHHHHCCCCCC	27.96	25338131
809	Phosphorylation	NLEKKYSSLTGGKGF CHHHHHHHCCCCCCC	27.19	26824392
890	Phosphorylation	KQHKEGLYLSDTLPR HHHHCCCCCCCCCCC	18.28	29514104
892	Phosphorylation	HKEGLYLSDTLPRKK HHCCCCCCCCCCCCC	18.26	26824392
894	Phosphorylation	EGLYLSDTLPRKKTT CCCCCCCCCCCCCCC	34.97	26824392
900	Phosphorylation	DTLPRKKTTPSLSPH CCCCCCCCCCCCCCC	47.15	25168779
901	Phosphorylation	TLPRKKTTPSLSPHF CCCCCCCCCCCCCCC	21.54	26643407
903	Phosphorylation	PRKKTTPSLSPHFSS CCCCCCCCCCCCCCC	39.11	24899341
905	Phosphorylation	KKTTPSLSPHFSSAT CCCCCCCCCCCCCCC	22.21	26824392
909	Phosphorylation	PSLSPHFSSATMGRS CCCCCCCCCCCCCCC	18.94	24899341
910	Phosphorylation	SLSPHFSSATMGRST CCCCCCCCCCCCCCC	27.15	26643407
912	Phosphorylation	SPHFSSATMGRSTTP CCCCCCCCCCCCCCC	23.31	26824392
928	Phosphorylation	AHLPLGQSNSCGSVL CCCCCCCCCCCCCCC	28.98	25521595
930	Phosphorylation	LPLGQSNSCGSVLPH CCCCCCCCCCCCCCH	25.71	27087446
933	Phosphorylation	GQSNSCGSVLPHSLA CCCCCCCCCCCHHHH	25.47	27087446
938	Phosphorylation	CGSVLPHSLATMTKD CCCCCCHHHHHCCCC	20.12	21743459
941	Phosphorylation	VLPHSLATMTKDSES CCCHHHHHCCCCHHH	30.57	21743459
943	Phosphorylation	PHSLATMTKDSESRR CHHHHHCCCCHHHHH	27.61	21743459
955	Phosphorylation	SRRMLRGYNHQQMSE HHHHHHCCCHHHCCC	11.75	29514104
972	Phosphorylation	RQKPEFYSRTASESN CCCCHHHHCCCCCCC	28.60	29514104
974	Phosphorylation	KPEFYSRTASESNVY CCHHHHCCCCCCCEE	28.70	27087446
976	Phosphorylation	EFYSRTASESNVYLN HHHHCCCCCCCEEEC	40.73	25521595
978	Phosphorylation	YSRTASESNVYLNSF HHCCCCCCCEEECCC	29.15	21082442
981	Phosphorylation	TASESNVYLNSFHYP CCCCCCEEECCCCCC	12.38	26239621
984	Phosphorylation	ESNVYLNSFHYPDRS CCCEEECCCCCCCCC	15.71	26239621
987	Phosphorylation	VYLNSFHYPDRSYKD EEECCCCCCCCCCCC	12.57	25777480
1106	Phosphorylation	RAQARPLTRYLPVRK HHHHCCCHHCCCCCH	21.68	24719451
1108	Phosphorylation	QARPLTRYLPVRKED HHCCCHHCCCCCHHH	15.32	29514104
1136	Phosphorylation	IDTCFHVSITEKTCR CCCEEEEEECCHHHH	18.41	28542873
1152	Acetylation	YLIKMGGKIKTWKKR EEEECCCEECEEECE	34.99	7616809
1154	Acetylation	IKMGGKIKTWKKRWF EECCCEECEEECEEE	52.39	7616821

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
17	S	Phosphorylation	Kinase	MTOR	Q9JLN9	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PHLB2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PHLB2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PHLB2_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PHLB2_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-465 AND SER-510, ANDMASS SPECTROMETRY.	19131326 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-465 AND SER-510, ANDMASS SPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-894 AND SER-976, ANDMASS SPECTROMETRY.	17242355 [Abstract]
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-389, AND MASSSPECTROMETRY.	17203969 [Abstract]