ELAV4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ELAV4_MOUSE
• UniProt AC: Q61701
• Protein Name: ELAV-like protein 4
• Gene Name: Elavl4
• Organism: Mus musculus (Mouse).
• Sequence Length: 385
• Protein Description: May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR. Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA (By similarity)..
• Protein Sequence: MEWNGLKMIISTMEPQVSNGPTSNTSNGPSSNNRNCPSPMQTGAATDDSKTNLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSGATEPITVKFANNPSQKSSQALLSQLYQSPNRRYPGPLHHQAQRFRLDNLLNMAYGVKRLMSGPVPPSACPPRFSPITIDGMTSLVGMNIPGHTGTGWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKAHKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	NGLKMIISTMEPQVS CCEEEEHHCCCCCCC	15.69	25293948
12	Phosphorylation	GLKMIISTMEPQVSN CEEEEHHCCCCCCCC	18.36	25293948
18	Phosphorylation	STMEPQVSNGPTSNT HCCCCCCCCCCCCCC	30.71	25293948
22	Phosphorylation	PQVSNGPTSNTSNGP CCCCCCCCCCCCCCC	35.69	25293948
23	Phosphorylation	QVSNGPTSNTSNGPS CCCCCCCCCCCCCCC	41.04	25293948
25	Phosphorylation	SNGPTSNTSNGPSSN CCCCCCCCCCCCCCC	24.28	25293948
26	Phosphorylation	NGPTSNTSNGPSSNN CCCCCCCCCCCCCCC	44.00	25293948
30	Phosphorylation	SNTSNGPSSNNRNCP CCCCCCCCCCCCCCC	47.28	25293948
31	Phosphorylation	NTSNGPSSNNRNCPS CCCCCCCCCCCCCCC	41.06	25293948
38	Phosphorylation	SNNRNCPSPMQTGAA CCCCCCCCCCCCCCC	34.89	25521595
42	Phosphorylation	NCPSPMQTGAATDDS CCCCCCCCCCCCCCC	23.65	22324799
46	Phosphorylation	PMQTGAATDDSKTNL CCCCCCCCCCCCCCE	39.54	25159016
49	Phosphorylation	TGAATDDSKTNLIVN CCCCCCCCCCCEEEE	44.16	25159016
63	Phosphorylation	NYLPQNMTQEEFRSL ECCCCCCCHHHHHHH	40.14	30635358
86	Ubiquitination	SCKLVRDKITGQSLG HCEEECCCCCCCCCC	31.44	-
103	Ubiquitination	FVNYIDPKDAEKAIN ECEECCHHHHHHHHH	66.86	-
107	Ubiquitination	IDPKDAEKAINTLNG CCHHHHHHHHHHHHC	57.18	-
125	Phosphorylation	QTKTIKVSYARPSSA EEEEEEEEEECCCCC	14.20	19737024
126	Phosphorylation	TKTIKVSYARPSSAS EEEEEEEEECCCCCC	15.04	19737024
130	Phosphorylation	KVSYARPSSASIRDA EEEEECCCCCCCCCC	32.74	28066266
131	Phosphorylation	VSYARPSSASIRDAN EEEECCCCCCCCCCC	28.81	22817900
133	Phosphorylation	YARPSSASIRDANLY EECCCCCCCCCCCEE	21.80	28066266
146	Ubiquitination	LYVSGLPKTMTQKEL EEECCCCCCCCHHHH	56.84	-
146	Ubiquitination	LYVSGLPKTMTQKEL EEECCCCCCCCHHHH	56.84	-
149	Phosphorylation	SGLPKTMTQKELEQL CCCCCCCCHHHHHHH	41.54	-
151	Ubiquitination	LPKTMTQKELEQLFS CCCCCCHHHHHHHHH	55.91	-
151	Ubiquitination	LPKTMTQKELEQLFS CCCCCCHHHHHHHHH	55.91	-
165	Phosphorylation	SQYGRIITSRILVDQ HHHHHHHHHHHHHHH	15.02	-
211	Phosphorylation	SGATEPITVKFANNP CCCCCCEEEEECCCC	28.49	-
221	Ubiquitination	FANNPSQKSSQALLS ECCCCCHHHHHHHHH	57.31	-
221	Ubiquitination	FANNPSQKSSQALLS ECCCCCHHHHHHHHH	57.31	-
222	Phosphorylation	ANNPSQKSSQALLSQ CCCCCHHHHHHHHHH	21.75	23527152
223	Phosphorylation	NNPSQKSSQALLSQL CCCCHHHHHHHHHHH	26.89	20415495
228	Phosphorylation	KSSQALLSQLYQSPN HHHHHHHHHHHCCCC	20.99	24759943
231	Phosphorylation	QALLSQLYQSPNRRY HHHHHHHHCCCCCCC	10.17	25521595
233	Phosphorylation	LLSQLYQSPNRRYPG HHHHHHCCCCCCCCC	15.58	25521595
237	Dimethylation	LYQSPNRRYPGPLHH HHCCCCCCCCCCCCH	48.95	-
248	Methylation	PLHHQAQRFRLDNLL CCCHHHHHHHHHHHH	22.97	-
250	Dimethylation	HHQAQRFRLDNLLNM CHHHHHHHHHHHHHH	43.23	-
262	Ubiquitination	LNMAYGVKRLMSGPV HHHHHHHHHHHCCCC	35.14	-
262	Ubiquitination	LNMAYGVKRLMSGPV HHHHHHHHHHHCCCC	35.14	-
327	Ubiquitination	QLFGPFGAVNNVKVI HHHCCCCCCCCEEEE	10.97	-
341	Ubiquitination	IRDFNTNKCKGFGFV EEECCCCCCCCEEEE	34.97	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ELAV4_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
248	R	Methylation	Methylation at Arg-248 by CARM1 weakens protective binding to the 3'UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state (By similarity).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ELAV4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
G3BP1_MOUSE	G3bp1	physical	15086518

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.