UniProt ID | ELAV4_MOUSE | |
---|---|---|
UniProt AC | Q61701 | |
Protein Name | ELAV-like protein 4 | |
Gene Name | Elavl4 | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 385 | |
Subcellular Localization | ||
Protein Description | May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR. Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA (By similarity).. | |
Protein Sequence | MEWNGLKMIISTMEPQVSNGPTSNTSNGPSSNNRNCPSPMQTGAATDDSKTNLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSGATEPITVKFANNPSQKSSQALLSQLYQSPNRRYPGPLHHQAQRFRLDNLLNMAYGVKRLMSGPVPPSACPPRFSPITIDGMTSLVGMNIPGHTGTGWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKAHKS | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
11 | Phosphorylation | NGLKMIISTMEPQVS CCEEEEHHCCCCCCC | 15.69 | 25293948 | |
12 | Phosphorylation | GLKMIISTMEPQVSN CEEEEHHCCCCCCCC | 18.36 | 25293948 | |
18 | Phosphorylation | STMEPQVSNGPTSNT HCCCCCCCCCCCCCC | 30.71 | 25293948 | |
22 | Phosphorylation | PQVSNGPTSNTSNGP CCCCCCCCCCCCCCC | 35.69 | 25293948 | |
23 | Phosphorylation | QVSNGPTSNTSNGPS CCCCCCCCCCCCCCC | 41.04 | 25293948 | |
25 | Phosphorylation | SNGPTSNTSNGPSSN CCCCCCCCCCCCCCC | 24.28 | 25293948 | |
26 | Phosphorylation | NGPTSNTSNGPSSNN CCCCCCCCCCCCCCC | 44.00 | 25293948 | |
30 | Phosphorylation | SNTSNGPSSNNRNCP CCCCCCCCCCCCCCC | 47.28 | 25293948 | |
31 | Phosphorylation | NTSNGPSSNNRNCPS CCCCCCCCCCCCCCC | 41.06 | 25293948 | |
38 | Phosphorylation | SNNRNCPSPMQTGAA CCCCCCCCCCCCCCC | 34.89 | 25521595 | |
42 | Phosphorylation | NCPSPMQTGAATDDS CCCCCCCCCCCCCCC | 23.65 | 22324799 | |
46 | Phosphorylation | PMQTGAATDDSKTNL CCCCCCCCCCCCCCE | 39.54 | 25159016 | |
49 | Phosphorylation | TGAATDDSKTNLIVN CCCCCCCCCCCEEEE | 44.16 | 25159016 | |
63 | Phosphorylation | NYLPQNMTQEEFRSL ECCCCCCCHHHHHHH | 40.14 | 30635358 | |
86 | Ubiquitination | SCKLVRDKITGQSLG HCEEECCCCCCCCCC | 31.44 | - | |
103 | Ubiquitination | FVNYIDPKDAEKAIN ECEECCHHHHHHHHH | 66.86 | - | |
107 | Ubiquitination | IDPKDAEKAINTLNG CCHHHHHHHHHHHHC | 57.18 | - | |
125 | Phosphorylation | QTKTIKVSYARPSSA EEEEEEEEEECCCCC | 14.20 | 19737024 | |
126 | Phosphorylation | TKTIKVSYARPSSAS EEEEEEEEECCCCCC | 15.04 | 19737024 | |
130 | Phosphorylation | KVSYARPSSASIRDA EEEEECCCCCCCCCC | 32.74 | 28066266 | |
131 | Phosphorylation | VSYARPSSASIRDAN EEEECCCCCCCCCCC | 28.81 | 22817900 | |
133 | Phosphorylation | YARPSSASIRDANLY EECCCCCCCCCCCEE | 21.80 | 28066266 | |
146 | Ubiquitination | LYVSGLPKTMTQKEL EEECCCCCCCCHHHH | 56.84 | - | |
146 | Ubiquitination | LYVSGLPKTMTQKEL EEECCCCCCCCHHHH | 56.84 | - | |
149 | Phosphorylation | SGLPKTMTQKELEQL CCCCCCCCHHHHHHH | 41.54 | - | |
151 | Ubiquitination | LPKTMTQKELEQLFS CCCCCCHHHHHHHHH | 55.91 | - | |
151 | Ubiquitination | LPKTMTQKELEQLFS CCCCCCHHHHHHHHH | 55.91 | - | |
165 | Phosphorylation | SQYGRIITSRILVDQ HHHHHHHHHHHHHHH | 15.02 | - | |
211 | Phosphorylation | SGATEPITVKFANNP CCCCCCEEEEECCCC | 28.49 | - | |
221 | Ubiquitination | FANNPSQKSSQALLS ECCCCCHHHHHHHHH | 57.31 | - | |
221 | Ubiquitination | FANNPSQKSSQALLS ECCCCCHHHHHHHHH | 57.31 | - | |
222 | Phosphorylation | ANNPSQKSSQALLSQ CCCCCHHHHHHHHHH | 21.75 | 23527152 | |
223 | Phosphorylation | NNPSQKSSQALLSQL CCCCHHHHHHHHHHH | 26.89 | 20415495 | |
228 | Phosphorylation | KSSQALLSQLYQSPN HHHHHHHHHHHCCCC | 20.99 | 24759943 | |
231 | Phosphorylation | QALLSQLYQSPNRRY HHHHHHHHCCCCCCC | 10.17 | 25521595 | |
233 | Phosphorylation | LLSQLYQSPNRRYPG HHHHHHCCCCCCCCC | 15.58 | 25521595 | |
237 | Dimethylation | LYQSPNRRYPGPLHH HHCCCCCCCCCCCCH | 48.95 | - | |
248 | Methylation | PLHHQAQRFRLDNLL CCCHHHHHHHHHHHH | 22.97 | - | |
250 | Dimethylation | HHQAQRFRLDNLLNM CHHHHHHHHHHHHHH | 43.23 | - | |
262 | Ubiquitination | LNMAYGVKRLMSGPV HHHHHHHHHHHCCCC | 35.14 | - | |
262 | Ubiquitination | LNMAYGVKRLMSGPV HHHHHHHHHHHCCCC | 35.14 | - | |
327 | Ubiquitination | QLFGPFGAVNNVKVI HHHCCCCCCCCEEEE | 10.97 | - | |
341 | Ubiquitination | IRDFNTNKCKGFGFV EEECCCCCCCCEEEE | 34.97 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ELAV4_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference |
---|---|---|---|---|
248 | R | Methylation |
| - |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ELAV4_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
G3BP1_MOUSE | G3bp1 | physical | 15086518 |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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