ZEB1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZEB1_MOUSE
• UniProt AC: Q64318
• Protein Name: Zinc finger E-box-binding homeobox 1
• Gene Name: Zeb1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1117
• Subcellular Localization: Nucleus .
• Protein Description: Acts as a transcriptional repressor. Binds to E-box sequences in the immunoglobulin heavy chain enhancer as well as in the regulatory regions of many other tissue-specific genes. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1 (By similarity). Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs..
• Protein Sequence: MADGPRCKRRKQANPRRNNVTNYNTVVEANSDSDDEDKLHIVEEESITDAADCEGGMPDDELPADQTVLPGGSDRGGGAKNCWQDNVKDNECDSDAENEQNHDPNVEEFLQQQDTAVIYPEAPEEDQRQGTPEASSHDENGTPDAFSQLLTCPYCDRGYKRFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGREQRHVTQSGGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLMPVNGRPRSGLKTSQCSSPSLSTSPGSPTRPQIRQKIENKPLQEPLSVNQIKTEPVDYEFKPIVVASGINCSTPLQNGVFSSGGQLQATSSPQGVVQAVVLPTVGLVSPISINLSDIQNVLKVAVDGNVIRQVLETNQASLASKEQEAVSASPIQQGGHSVISAISLPLVDQDGTTKIIINYSLEQPSQLQVVPQNLKKEIPAPTNSCKSEKLPEDLTVKSETDKSFEGARDDSTCLLCEDCPGDLNALPELKHYDPECPAQPPPPAPATEKPESSASSAGNGDLSPSQPPLKNLLSLLKAYYALNAQPSTEELSKIADSVNLPLDGVKKWFEKMQAGQIPGQSPDPPSPGTGSVNIPTKTDEQPQPADGNEPQEDSTRGQSPVKIRSSPVLPVGSAMNGSRSCTSSPSPLNLCSARNPQGYSCVAEGAQEEPQVEPLDLSLPKQQGELLERSTVSSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVTDSEPVVNVVPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQVAYTYSATVSPAVQEPPVKVIQPNGNQDERQDTSSEGVSTVEDQNDSDSTPPKKKTRKTENGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICRKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKRGAEDRDAMEQEDAGPEVLPEVLATEHVGARASPSQADSDERESLTREEDEDSEKEEEEEDKEMEELQEGKECENPQGEEEEEEEEEEEEEEEEEEEVEADEAEHEAAAKTDGTVEVGAAQQAGSLEQKASESEMESESESEQLSEEKTNEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	NNVTNYNTVVEANSD CCCCCCCCEEECCCC	18.63	28285833
31	Phosphorylation	NTVVEANSDSDDEDK CCEEECCCCCCCCCC	45.60	27087446
33	Phosphorylation	VVEANSDSDDEDKLH EEECCCCCCCCCCEE	46.94	27087446
94	Phosphorylation	VKDNECDSDAENEQN CCCCCCCCHHHHHHC	50.83	25338131
164	Phosphorylation	RGYKRFTSLKEHIKY CCCHHHHHHHHHHHH	34.43	29176673
200	Phosphorylation	TQLERHMTSHKSGRE HHHHHHHHCCCCCCC	22.89	24759943
201	Phosphorylation	QLERHMTSHKSGREQ HHHHHHHCCCCCCCC	22.73	24759943
204	Phosphorylation	RHMTSHKSGREQRHV HHHHCCCCCCCCEEE	37.34	24759943
212	Phosphorylation	GREQRHVTQSGGNRK CCCCEEEECCCCCCE	15.76	23737553
214	Phosphorylation	EQRHVTQSGGNRKFK CCEEEECCCCCCEEE	39.02	23737553
262	Phosphorylation	KRFSHSGSYSSHISS CCCCCCCCCCCCCCC	25.51	22871156
263	Phosphorylation	RFSHSGSYSSHISSK CCCCCCCCCCCCCCC	20.09	22871156
264	Phosphorylation	FSHSGSYSSHISSKK CCCCCCCCCCCCCCC	19.69	22871156
284	Phosphorylation	PVNGRPRSGLKTSQC ECCCCCCCCCCCCCC	51.68	26160508
288	Phosphorylation	RPRSGLKTSQCSSPS CCCCCCCCCCCCCCC	29.13	25619855
289	Phosphorylation	PRSGLKTSQCSSPSL CCCCCCCCCCCCCCC	27.83	25619855
292	Phosphorylation	GLKTSQCSSPSLSTS CCCCCCCCCCCCCCC	37.33	25619855
293	Phosphorylation	LKTSQCSSPSLSTSP CCCCCCCCCCCCCCC	26.57	26824392
295	Phosphorylation	TSQCSSPSLSTSPGS CCCCCCCCCCCCCCC	36.58	25619855
297	Phosphorylation	QCSSPSLSTSPGSPT CCCCCCCCCCCCCCC	31.04	25619855
298	Phosphorylation	CSSPSLSTSPGSPTR CCCCCCCCCCCCCCC	44.21	25619855
299	Phosphorylation	SSPSLSTSPGSPTRP CCCCCCCCCCCCCCH	24.72	21082442
302	Phosphorylation	SLSTSPGSPTRPQIR CCCCCCCCCCCHHHH	26.87	27087446
304	Phosphorylation	STSPGSPTRPQIRQK CCCCCCCCCHHHHHH	57.59	22942356
425	Phosphorylation	SKEQEAVSASPIQQG HHCHHHHCCCCCCCC	30.03	23984901
427	Phosphorylation	EQEAVSASPIQQGGH CHHHHCCCCCCCCCC	18.28	25777480
435	Phosphorylation	PIQQGGHSVISAISL CCCCCCCEEEEEEEC	25.15	23984901
438	Phosphorylation	QGGHSVISAISLPLV CCCCEEEEEEECEEE	19.86	23984901
441	Phosphorylation	HSVISAISLPLVDQD CEEEEEEECEEECCC	24.53	23984901
450	Phosphorylation	PLVDQDGTTKIIINY EEECCCCCEEEEEEE	32.95	25777480
451	Phosphorylation	LVDQDGTTKIIINYS EECCCCCEEEEEEEE	26.27	25777480
501	Phosphorylation	VKSETDKSFEGARDD ECCCCCCCCCCCCCC	31.19	27149854
561	Phosphorylation	SAGNGDLSPSQPPLK CCCCCCCCCCCCCHH	27.52	25266776
619	Phosphorylation	AGQIPGQSPDPPSPG CCCCCCCCCCCCCCC	36.87	27087446
624	Phosphorylation	GQSPDPPSPGTGSVN CCCCCCCCCCCCCCC	41.15	25521595
627	Phosphorylation	PDPPSPGTGSVNIPT CCCCCCCCCCCCCCC	29.66	25619855
629	Phosphorylation	PPSPGTGSVNIPTKT CCCCCCCCCCCCCCC	16.30	25619855
634	Phosphorylation	TGSVNIPTKTDEQPQ CCCCCCCCCCCCCCC	42.66	25619855
636	Phosphorylation	SVNIPTKTDEQPQPA CCCCCCCCCCCCCCC	47.44	27087446
652	Phosphorylation	GNEPQEDSTRGQSPV CCCCCCCCCCCCCCC	21.17	26643407
653	Phosphorylation	NEPQEDSTRGQSPVK CCCCCCCCCCCCCCE	51.66	26643407
657	Phosphorylation	EDSTRGQSPVKIRSS CCCCCCCCCCEECCC	34.19	27087446
663	Phosphorylation	QSPVKIRSSPVLPVG CCCCEECCCCEECCC	42.33	21082442
664	Phosphorylation	SPVKIRSSPVLPVGS CCCEECCCCEECCCC	14.80	21082442
671	Phosphorylation	SPVLPVGSAMNGSRS CCEECCCCCCCCCCC	25.28	26745281
676	Phosphorylation	VGSAMNGSRSCTSSP CCCCCCCCCCCCCCC	18.93	26160508
678	Phosphorylation	SAMNGSRSCTSSPSP CCCCCCCCCCCCCCC	24.36	25521595
680	Phosphorylation	MNGSRSCTSSPSPLN CCCCCCCCCCCCCCC	33.22	21082442
681	Phosphorylation	NGSRSCTSSPSPLNL CCCCCCCCCCCCCCC	44.58	27149854
682	Phosphorylation	GSRSCTSSPSPLNLC CCCCCCCCCCCCCCC	15.96	25521595
684	Phosphorylation	RSCTSSPSPLNLCSA CCCCCCCCCCCCCCC	43.92	22942356
690	Phosphorylation	PSPLNLCSARNPQGY CCCCCCCCCCCCCCC	33.17	25619855
865	Phosphorylation	TVEDQNDSDSTPPKK CCCCCCCCCCCCCCC	40.80	25619855
867	Phosphorylation	EDQNDSDSTPPKKKT CCCCCCCCCCCCCCC	46.92	25619855
868	Phosphorylation	DQNDSDSTPPKKKTR CCCCCCCCCCCCCCC	48.91	25619855
895	Phosphorylation	DKIFQKSSSLLRHKY HHHHHHCHHHHHHHC	31.85	24719451
896	Phosphorylation	KIFQKSSSLLRHKYE HHHHHCHHHHHHHCC	38.21	27149854
933	Phosphorylation	IEHMRLHSGEKPYQC HHHHHCCCCCCCCCC	53.92	28066266
938	Phosphorylation	LHSGEKPYQCDKCGK CCCCCCCCCCCCCCC	32.61	28066266
998	Phosphorylation	EHVGARASPSQADSD CCCCCCCCHHHCCHH	21.38	25263469
1000	Phosphorylation	VGARASPSQADSDER CCCCCCHHHCCHHHH	35.19	24899341
1004	Phosphorylation	ASPSQADSDERESLT CCHHHCCHHHHHCCC	44.37	25195567
1009	Phosphorylation	ADSDERESLTREEDE CCHHHHHCCCHHCCC	41.06	24899341
1018	Phosphorylation	TREEDEDSEKEEEEE CHHCCCCHHHHHHHH	48.82	23737553
1090	Phosphorylation	GAAQQAGSLEQKASE CHHHHHCCHHHHHCH	31.58	27841257
1096	Phosphorylation	GSLEQKASESEMESE CCHHHHHCHHHHHCH	49.00	25338131
1098	Phosphorylation	LEQKASESEMESESE HHHHHCHHHHHCHHH	39.48	25338131
1102	Phosphorylation	ASESEMESESESEQL HCHHHHHCHHHHHHH	45.15	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZEB1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZEB1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZEB1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTBP1_MOUSE	Ctbp1	physical	10567582
CTBP2_MOUSE	Ctbp2	physical	10567582
CTBP2_MOUSE	Ctbp2	physical	12714599

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.