CAMP1_MOUSE - dbPTM
CAMP1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CAMP1_MOUSE
UniProt AC A2AHC3
Protein Name Calmodulin-regulated spectrin-associated protein 1
Gene Name Camsap1
Organism Mus musculus (Mouse).
Sequence Length 1581
Subcellular Localization Cytoplasm, cytoskeleton . Associates with the minus-end of microtubules. In contrast to CAMSAP2 and CAMSAP3, does not form stretches of decorated microtubule minus-ends.
Protein Description Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus-ends and stabilizes microtubules. Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization. In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation. Through interaction with spectrin may regulate neurite outgrowth..
Protein Sequence MVDAGGRCAAEGWRRMEAPPEGADLVPLDRYDAARAKIAANLQWICAKAYGLDNIPEDLRDPFYIDQYEQEHIKPPVIKLLLSSELYCRVCSLILKGDQVATLQGHQSVIQALSRKGIYVMESDDTPVTDADLSQAPIKMSGHMAMVDALMMAYTVEMISIEKVVASVKRFSTFSASKELPYDLEDAMVFWINKVNLKMREITEKEVKLKQQPLESPAHQKVRYRREHLSARQSPYFPLLEDLMRDGSDGAALLAVVHYYCPEQMKLDDICLKEVPSMADSLYNIRLLREFSNEHLNKCFYLTLEDMLYAPLVLKPNVMVFIAELFWWFENVKPDFVQPRDIQELKDAKTVLQQKSSRPPVPISNATKRSFLGSPAAMSPADQPPSTQPLAEGSHRYHLHSEEPECLGKGASTFSPSHPLLPLRQKQQKVSQTEEIPDQRHRSNSLTRVDGQPRGAIGAWPDKKNRPVSQPTSFALHHAASCDVDPSSGDSVSLARSISKDSLASNIIHLTPQNQPHPSAGKSNGKSLLSNVNIEDEDEELVAIIRTDVSPPSPQMPRTSPQAPGLVASIRSPQRQADTLESKPDSFYLEPLMPAVLRPAKEKQITTKEDERGEGRPRTIMAKRPSEGSQPMVRKKVSGGHGSRDLNRTFTPIPCSEFAASIDLAEVGPQSAEATGEGQPLALGRFDTLPQGQAADGFFLHVGRAEEDEGRWYVGSQSPSSHDSEPWTILRQDSDSDVVDVEDTEQDFIGEDHPVVIPRYAGEEESAKLQEDMKVKEHEDKDDASGRSSPCLSTTSQLSSMSMASGSVKMTSFAERKLQRLNSCETKSSTSSSQKTTPDASESCPAPLTTWRQKREQSPGRHSKDPASLLASELVQLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAFLHVVKKGKADGAPQPLRPEHFTKEFTQHNGEDLDDGTCKTEGFLVKEEQRDLSDAQDVAFVQLHKPRDPAALHDGEKHRMISTALLEDSVGEVDVNECDLSIEKLNETISTLQQAILKISQQQEQLLMKSPTVPTPGTKNNCQDQKIKAPVHFVEPLSPTGVPGHRKPPRLGQGRNSRSGRPAELKVPKDRQQGCSRSKTPTPSVETLPQSRSLPPSTHPRSPSDPGGELPEKCLFDSYRLHDESNHRTFVLSSCKDANIVSEQVNFKEGLDTSVKEAGLSSSTITGKEHTPVEEPLRSKASLIEVDLSDLKAPDEDGEVVGHESSVELGGDSDQKPGVGFFFKDEQKAEDELAKKRAAFLLKQQRKAEEARARKQQLEAEVELKRDEARRKAEEDRLRKEEEKARRELIKQEYLRRKQQQALEEQGLGKPKSKPKKPRPKSVHREESYSDSGTKCSSTHNLSQTHSGSSLSLASAATTEPESVYSGGTPSHRVESLEALPILSRNPSRSTDRDWETASAASSLASVAEYTGPKLFKEPSSKSNKPIIHNAISHCCLAGKVNEPHKNSILELEKCDANHYIILFRDAGCQFRALYCYQPDTEEIYKLTGTGPKSITKKMIDKLYKYSSDRKQFNLIPAKTMSVSVDALTIHNHLWQPKRPTVPKKTQTRK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
216PhosphorylationLKQQPLESPAHQKVR
HCCCCCCCHHHHHHH		34.7629899451
234PhosphorylationEHLSARQSPYFPLLE
HHHHHHCCCCHHHHH		18.9325338131
370PhosphorylationISNATKRSFLGSPAA
CCHHCCCHHCCCCCC		26.7826643407
374PhosphorylationTKRSFLGSPAAMSPA
CCCHHCCCCCCCCCC		17.3226643407
379PhosphorylationLGSPAAMSPADQPPS
CCCCCCCCCCCCCCC		16.5326643407
412PhosphorylationECLGKGASTFSPSHP
CCCCCCCCCCCCCCC		38.3628066266
413PhosphorylationCLGKGASTFSPSHPL
CCCCCCCCCCCCCCC		27.8328066266
415PhosphorylationGKGASTFSPSHPLLP
CCCCCCCCCCCCCCC		26.1128066266
417PhosphorylationGASTFSPSHPLLPLR
CCCCCCCCCCCCCHH		36.2228066266
443PhosphorylationIPDQRHRSNSLTRVD
CCCHHHHCCCCEEEC		25.3325266776
445PhosphorylationDQRHRSNSLTRVDGQ
CHHHHCCCCEEECCC		32.1526824392
447PhosphorylationRHRSNSLTRVDGQPR
HHHCCCCEEECCCCC		28.5929550500
469PhosphorylationDKKNRPVSQPTSFAL
CCCCCCCCCCCCHHH		32.8828507225
472PhosphorylationNRPVSQPTSFALHHA
CCCCCCCCCHHHHHH		28.9225266776
473PhosphorylationRPVSQPTSFALHHAA
CCCCCCCCHHHHHHH		18.4023984901
481PhosphorylationFALHHAASCDVDPSS
HHHHHHHHCCCCCCC		16.1926160508
487PhosphorylationASCDVDPSSGDSVSL
HHCCCCCCCCCHHHH		42.3526160508
488PhosphorylationSCDVDPSSGDSVSLA
HCCCCCCCCCHHHHH		52.5926160508
491PhosphorylationVDPSSGDSVSLARSI
CCCCCCCHHHHHHHC		19.6826643407
493PhosphorylationPSSGDSVSLARSISK
CCCCCHHHHHHHCCH		21.9126643407
497PhosphorylationDSVSLARSISKDSLA
CHHHHHHHCCHHHHH		26.1325159016
499PhosphorylationVSLARSISKDSLASN
HHHHHHCCHHHHHHC		31.4927742792
502PhosphorylationARSISKDSLASNIIH
HHHCCHHHHHHCEEE		29.5825159016
505PhosphorylationISKDSLASNIIHLTP
CCHHHHHHCEEEECC		33.5825159016
511PhosphorylationASNIIHLTPQNQPHP
HHCEEEECCCCCCCC		14.5225293948
547PhosphorylationELVAIIRTDVSPPSP
CEEEEEEECCCCCCC		30.2825619855
550PhosphorylationAIIRTDVSPPSPQMP
EEEEECCCCCCCCCC		33.6225521595
553PhosphorylationRTDVSPPSPQMPRTS
EECCCCCCCCCCCCC		31.0225521595
559PhosphorylationPSPQMPRTSPQAPGL
CCCCCCCCCCCCCCH		38.6027087446
560PhosphorylationSPQMPRTSPQAPGLV
CCCCCCCCCCCCCHH		19.1225521595
569PhosphorylationQAPGLVASIRSPQRQ
CCCCHHHCCCCCCHH		15.8527087446
572PhosphorylationGLVASIRSPQRQADT
CHHHCCCCCCHHHHC		24.5819060867
586PhosphorylationTLESKPDSFYLEPLM
CCCCCCCCCCCCCCC		25.07-
626PhosphorylationTIMAKRPSEGSQPMV
EEEECCCCCCCCCCE		59.6329899451
638PhosphorylationPMVRKKVSGGHGSRD
CCEEEECCCCCCCCC		48.19-
643PhosphorylationKVSGGHGSRDLNRTF
ECCCCCCCCCCCCCC		19.5628059163
649PhosphorylationGSRDLNRTFTPIPCS
CCCCCCCCCCCCCHH		30.6826643407
651PhosphorylationRDLNRTFTPIPCSEF
CCCCCCCCCCCHHHH		21.5026643407
656PhosphorylationTFTPIPCSEFAASID
CCCCCCHHHHHEECC		30.3226643407
661PhosphorylationPCSEFAASIDLAEVG
CHHHHHEECCHHHHC		17.1326643407
713PhosphorylationEEDEGRWYVGSQSPS
ECCCCCEEECCCCCC		8.1225293948
716PhosphorylationEGRWYVGSQSPSSHD
CCCEEECCCCCCCCC		19.9026643407
718PhosphorylationRWYVGSQSPSSHDSE
CEEECCCCCCCCCCC		28.5721082442
720PhosphorylationYVGSQSPSSHDSEPW
EECCCCCCCCCCCCC		45.6226643407
721PhosphorylationVGSQSPSSHDSEPWT
ECCCCCCCCCCCCCE		34.4026643407
724PhosphorylationQSPSSHDSEPWTILR
CCCCCCCCCCCEEEE		39.8926643407
728PhosphorylationSHDSEPWTILRQDSD
CCCCCCCEEEECCCC		22.3529472430
734PhosphorylationWTILRQDSDSDVVDV
CEEEECCCCCCCCCC		30.5818388127
736PhosphorylationILRQDSDSDVVDVED
EEECCCCCCCCCCCC		35.9425521595
744PhosphorylationDVVDVEDTEQDFIGE
CCCCCCCCCCCCCCC		23.2625619855
785PhosphorylationHEDKDDASGRSSPCL
CCCCCCCCCCCCCCC		41.5629899451
788PhosphorylationKDDASGRSSPCLSTT
CCCCCCCCCCCCCCH		42.0025293948
789PhosphorylationDDASGRSSPCLSTTS
CCCCCCCCCCCCCHH		20.4725521595
793PhosphorylationGRSSPCLSTTSQLSS
CCCCCCCCCHHHHHH		36.0326643407
823PhosphorylationRKLQRLNSCETKSST
HHHHHHHHCCCCCCC		20.2327087446
826PhosphorylationQRLNSCETKSSTSSS
HHHHHCCCCCCCCCC		40.3226745281
858PhosphorylationWRQKREQSPGRHSKD
HHHHHHCCCCCCCCC		25.2722324799
863PhosphorylationEQSPGRHSKDPASLL
HCCCCCCCCCHHHHH		37.0826745281
868PhosphorylationRHSKDPASLLASELV
CCCCCHHHHHHHHHH		29.3326745281
872PhosphorylationDPASLLASELVQLHM
CHHHHHHHHHHHHHH		31.2822871156
1019PhosphorylationSIEKLNETISTLQQA
CHHHHHHHHHHHHHH		21.1028066266
1021PhosphorylationEKLNETISTLQQAIL
HHHHHHHHHHHHHHH		30.4128066266
1022PhosphorylationKLNETISTLQQAILK
HHHHHHHHHHHHHHH		25.4128066266
1041PhosphorylationQEQLLMKSPTVPTPG
HHHHHHCCCCCCCCC		16.3129514104
1069PhosphorylationVHFVEPLSPTGVPGH
EEEECCCCCCCCCCC		31.0026824392
1071PhosphorylationFVEPLSPTGVPGHRK
EECCCCCCCCCCCCC		47.6528833060
1109PhosphorylationRQQGCSRSKTPTPSV
CCCCCCCCCCCCCCC		25.2925619855
1111PhosphorylationQGCSRSKTPTPSVET
CCCCCCCCCCCCCCC		33.3726824392
1113PhosphorylationCSRSKTPTPSVETLP
CCCCCCCCCCCCCCC		33.1725619855
1115PhosphorylationRSKTPTPSVETLPQS
CCCCCCCCCCCCCCC		34.7525619855
1124PhosphorylationETLPQSRSLPPSTHP
CCCCCCCCCCCCCCC		50.9425777480
1128PhosphorylationQSRSLPPSTHPRSPS
CCCCCCCCCCCCCCC		37.0923984901
1129PhosphorylationSRSLPPSTHPRSPSD
CCCCCCCCCCCCCCC		41.4925266776
1133PhosphorylationPPSTHPRSPSDPGGE
CCCCCCCCCCCCCCC		32.9525521595
1135PhosphorylationSTHPRSPSDPGGELP
CCCCCCCCCCCCCCC		58.6525521595
1165PhosphorylationHRTFVLSSCKDANIV
CCEEEEECCCCCCCC		22.4827357545
1193PhosphorylationVKEAGLSSSTITGKE
HHHCCCCCCCCCCCC		36.2222871156
1194PhosphorylationKEAGLSSSTITGKEH
HHCCCCCCCCCCCCC		22.0622871156
1202PhosphorylationTITGKEHTPVEEPLR
CCCCCCCCCCCCCCC		30.0725521595
1210PhosphorylationPVEEPLRSKASLIEV
CCCCCCCCCCCEEEE		40.0129899451
1213PhosphorylationEPLRSKASLIEVDLS
CCCCCCCCEEEEEHH		33.3529899451
1220PhosphorylationSLIEVDLSDLKAPDE
CEEEEEHHHCCCCCC		36.1128066266
1353PhosphorylationPKKPRPKSVHREESY
CCCCCCCCCCCCCCC		26.3226824392
1359PhosphorylationKSVHREESYSDSGTK
CCCCCCCCCCCCCCC		25.7830635358
1360PhosphorylationSVHREESYSDSGTKC
CCCCCCCCCCCCCCC		21.5630635358
1361PhosphorylationVHREESYSDSGTKCS
CCCCCCCCCCCCCCC		34.2823608596
1363PhosphorylationREESYSDSGTKCSST
CCCCCCCCCCCCCCC		42.2823608596
1365PhosphorylationESYSDSGTKCSSTHN
CCCCCCCCCCCCCCC		32.5929550500
1378PhosphorylationHNLSQTHSGSSLSLA
CCCCCCCCCCCEEHH		43.70-
1407PhosphorylationTPSHRVESLEALPIL
CCCHHEECHHHCCHH		28.7526824392
1428PhosphorylationSTDRDWETASAASSL
CCCCCHHHHHHHHHH		22.9729899451
1430PhosphorylationDRDWETASAASSLAS
CCCHHHHHHHHHHHH		31.6129899451
1433PhosphorylationWETASAASSLASVAE
HHHHHHHHHHHHHHH		26.1229899451
1434PhosphorylationETASAASSLASVAEY
HHHHHHHHHHHHHHH		24.1929899451
1508PhosphorylationQFRALYCYQPDTEEI
EEEEEEEECCCHHHH		14.99-
1516PhosphorylationQPDTEEIYKLTGTGP
CCCHHHHHHHHCCCC		11.83-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CAMP1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CAMP1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CAMP1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CAMP1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CAMP1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-553, AND MASSSPECTROMETRY.
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-550, AND MASSSPECTROMETRY.

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