HOOK3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HOOK3_MOUSE
• UniProt AC: Q8BUK6
• Protein Name: Protein Hook homolog 3
• Gene Name: Hook3
• Organism: Mus musculus (Mouse).
• Sequence Length: 718
• Subcellular Localization: Cytoplasm, cytoskeleton . Golgi apparatus . Enriched at the cis-face of the Golgi complex (By similarity). Localizes to microtubule asters in prophase (By similarity). Localizes to the manchette in elongating spermatids (PubMed:28003339).
• Protein Description: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex (By similarity). Serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. [PubMed: 12950921 Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity]
• Protein Sequence: MFNVESVERVELCESLLTWIQTFNVDAPCQTAEDLTNGVVMSQVLQKIDPVYFDDNWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGHDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQILMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARGQLETYKRQVVELQNRLSDESKKADKLDFEYKRLKEKVDGLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEDSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLRIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQRDMEEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSTRRSYPGHVQPATAR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MFNVESVE -------CCCHHHHH	5.07	-
6	Phosphorylation	--MFNVESVERVELC --CCCHHHHHHHHHH	25.62	29514104
165	Phosphorylation	MSKESPVSAGHDAYV HCCCCCCCCCCHHHH	31.73	25338131
230	Phosphorylation	LMERLNQSDSIEDPN HHHHHCCCCCCCCCC	32.05	28066266
232	Phosphorylation	ERLNQSDSIEDPNSP HHHCCCCCCCCCCCH	32.88	25619855
238	Phosphorylation	DSIEDPNSPAGRRHL CCCCCCCCHHHHHHH	22.86	25521595
410	Acetylation	VDGLQKEKDRLRTER HCHHHHHHHHHHHHH	56.00	15612595
419	Phosphorylation	RLRTERDSLKETIEE HHHHHHHHHHHHHHH	47.78	29899451
421	Ubiquitination	RTERDSLKETIEELR HHHHHHHHHHHHHHH	57.68	-
484	Phosphorylation	LKLNQEDSDNEKIAL CCCCCCCCHHHHHHH	41.40	20495213
488	Ubiquitination	QEDSDNEKIALLQSL CCCCHHHHHHHHHHH	39.26	-
604	Phosphorylation	MKQMEERYKKYLEKA HHHHHHHHHHHHHHH	18.34	29109428
646	Phosphorylation	ERDRLFHSLEKEYEK HHHHHHHHHHHHHHH	30.78	26824392
687	Phosphorylation	AAEDRLASTGSGQSF HHHHHHHHCCCCHHH	37.58	28066266
688	Phosphorylation	AEDRLASTGSGQSFL HHHHHHHCCCCHHHH	29.74	28066266
690	Phosphorylation	DRLASTGSGQSFLAR HHHHHCCCCHHHHHH	33.47	28066266
693	Phosphorylation	ASTGSGQSFLARQRQ HHCCCCHHHHHHHHH	26.25	29176673
707	Phosphorylation	QATSTRRSYPGHVQP HCCCCCCCCCCCCCC	32.18	25521595
708	Phosphorylation	ATSTRRSYPGHVQPA CCCCCCCCCCCCCCC	16.06	26239621

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HOOK3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HOOK3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HOOK3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of HOOK3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.