| UniProt ID | FRY_MOUSE | |
|---|---|---|
| UniProt AC | E9Q8I9 | |
| Protein Name | Protein furry homolog | |
| Gene Name | Fry | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 3020 | |
| Subcellular Localization | Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Distributed diffusely throughout the cytoplasm in interphase. Localizes to the separating centrosomes in prophase, to the spindle po | |
| Protein Description | Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.. | |
| Protein Sequence | MASQQDSGFFEISIKYLLKSWSNASPVGNGYIKPPVPPASGTHREKGPPAMLPINVDPDSKPGEYVLKSLFVNFTTQAERKIRIIMAEPLEKPLTKSLQRGEDPQFDQVISSMSSLSEYCLPSILRTLFDWYKRQNGIEDESHEYRPRTSNKSKSDEQQRDYLMERRDLAIDFIFSLVLIEVLKQIPLHPVIDSLIHDIINLAFKHFKYKEGYLGPNTGNMHIVADLYAEVIGVLAQAKFPAVKKKFMAELKELRHKEQSPYVVQSIISLIMGMKFFRIKMYPVEDFEASLQFMQECAHYFLEVKDKDIKHALAGLFVEILVPVAAAVKNEVNVPCLRNFVESLYDTTLELSSRKKHSLALYPLVTCLLCVSQKQLFLNRWHVFLNNCLSNLKNKDPKMARVALESLYRLLWVYMIRIKCESNTATQSRLITITTTLFPKGSRGVVPRDMPLNIFVKIIQFIAQERLDFAMKEIIFDFLCVGKPAKAFSLNPERMNIGLRAFLVIADSLQQKDGEPPMPVTGAVLPSGNTLRVKKTYLSKTLTEEEAKMIGMSLYYSQVRKAVGNILRHLDKEVGRCMMLTNVQMLNKEPEDMITGERKPKIDLFRTCVAAIPRLLPDGMSKLELIDLLARLSIHMDDELRHIAQNSLQGLLVDFSDWREDVLFGFTNFLLREVNDMHHTLLDSSLKLLLQLLTQWKLVIQTQGRAYEQANKIRNSELIPNGSSHRMQSERGPHCSVLHAVEGFALVLLCSFQVATRKLSVLILKEIRALFLALGQPEDDDRPMIDVMDQLSSSILESFIHVAVSDSATLPPTHNVDLQWLVEWNAVLVNSHYDVKSPSHVWIFAQSVKDPWVLCLFSFLRQENLPKHCPTALSYAWPYAFTRLQSVMPLVDPNSPVNAKKTSTASSGDNYVTLWRNYLILCFGVAKPSIMSPGHLRASTPEIMATTPDGTVSYDNKAIGTPSVGVLLKQLVPLMRLESIEITESLVLGFGRTNSLVFRELVEELHPLMKEALERRPENKKRRERRDLLRLQLLRIFELLADAGVISDSTNGALERDTLALGALFLEYVDLTRMLLEAENDKEVEILKDIRAHFSAMVANLIQCVPVHHRRFLFPQQSLRHHLFILFSQWAGPFSIMFTPLDRYSDRNHQITRYQYCALKAMSAVLCCGPVFDNVGLSPDGYLYKWLDNILACQDLRVHQLGCEVVMLLLELNPDQINLFNWAIDRCYTGSYQLASGCFKAIATVCGNRNYPFDIVTLLNLVLFKASDTNREIYEVSMQLMQILEAKLFVHSKKVAEQRPGSILYGTHGPLPPLYSVSLALLSCELARMYPELTLPLFSEVSQRFPTTHPNGRQIMLTYLLPWLHNIELVDSRLLLPGSSPSSPEDEVKDREGEVTASHGLKGNGWGSPEATSLVLNNLMYMTAKYGDEVPGAEMENAWNALANNEKWSNNLRVTLQFLISLCGVSSDTILLPYIKKVATYLCRNNTIQTMEELLFELQQTEPVNPIVQHCDNPPFYRFTASSKASAAASGTTSSSNTVVAGQDSFPDPEESKILKESDDRFSNVIRAHTRLESRYSNSSGGSYDEDKNDPISPYTGWLLSITEAKQPQPLPMPCSGGCWAPLVDYLPETITPRGPLHRCNIAVIFMTEMVVDHSVREDWALHLPLLLHAVFLGLDHYRPEVFEHSKKLLLHLLIALSCNSNFHAIASVLLQTREMGEAKTLTMQPAYQPEYLYTGGFDFLREDQSSPVPDSGLNSSSTSSSISLGGSSGNLPQMTQEVEDVEAATETDEKASKLIEFLTTRAFGPLWCHEDITPKNQNSKSAEQLSNFLRHVVSVFKDSRSGFHLEQHLSEVALQTALASSSRHYAGRSFQIFRALKQPLSAHALSDLLSRLVEVIGEHGDEIQGYVMEALLTLEAAVDNLSDCLKNSDLFTVLSRSSSPDLSSSSKLTASRKSTGQLNVNPGTPGSGGGGGGSGNTTTAERSRHQRSFSVPKKFGVVDRSSDPPRSATLDRIQACTQQGLSSKTRSNSSLKESLTDPSHVSHPTNLLATIFWVTVALMESDFEFEYLMALRLLNRLLAHMPLEKAENREKLEKLQAQLKWADFPGLQQLLLKGFTSLTTTDLTLQLFSLLTSVSKVPMVDSSQAIGFPLNVLCLLPQLIQHFENPNQFCKDIAERIAQVCLEEKNPKLSNLAHVMTLYKTHSYTRDCATWVNVVCRYLHEAYADITLNMVTYLAELLEKGLPSMQQPLLQVIYSLLSYMDLSVVPVKQFNMEVLKTIEKYVQSIHWREALNILKLVVSRSASLVLPSYQHSDLSKIELHRVWTSASKELPGKTLDFHFDISETPIIGRRYDELQNSSGRDGKPRAMAVTRSASSTSSGSNSNVLVPVSWKRPQYSQKRTKEKLVHVLSLCGQEVGLSKNPSVIFSSCGDLDLPEHQTSLVSSEDGPREQENMDDTNSEQQFRVFRDFDFLDVELEDGEGESMDNFNWGVRRRSLDSLDKCDMQILEERQLSRSTPSLNKMSHEDSDESSEEDLTASQILEHSDLIMNLSPSEEANPMELLTSACDSAPADPHSFNTRMANFEASLPDINNLQISEGSKAEAVPEEEDTTVHEDDLSSSINELPAAFECSDSFSLDMTEAEEKGNRGLDQYTLASFGEGDRGVSPPPSPFFSAILAAFQPAACDDAEEAWRSHINQLMCDSDGSCAVYTFHVFSSLFKNIQKRFCFLTCDAASYLGDNLRGIGSKFVSSSQMLTSCSECPTLFVDAETLLSCGLLDKLKFSVLELQEYLDTYNNRKEATLSWLANCKATFAGGSRDGVITCQPGDSEEKQLELCQRLYKLHFQLLLLYQSYCKLIGQVHEVSSVPELLNMSRELSDLKRNLKEATAAIATDPLYIEGAWSEPTFTSTEAAIQSMLECLKNNELGKALRQIKECRSLWPNDIFGSSSDDEVQTLLNIYFRHQTLGQTGTYALVGSNHSLTEICTKLMELNMEIRDMIRRAQNYRVLTAFLPDSSVSGTSL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 213 | Phosphorylation | HFKYKEGYLGPNTGN HCCCCCCCCCCCCCC | - | ||
| 358 | Phosphorylation | LSSRKKHSLALYPLV HHCCCCHHHHHHHHH | 25777480 | ||
| 362 | Phosphorylation | KKHSLALYPLVTCLL CCHHHHHHHHHHHHH | 25777480 | ||
| 366 | Phosphorylation | LALYPLVTCLLCVSQ HHHHHHHHHHHHHCH | 25777480 | ||
| 372 | Phosphorylation | VTCLLCVSQKQLFLN HHHHHHHCHHHHHHH | 25777480 | ||
| 432 | Phosphorylation | ATQSRLITITTTLFP CCHHEEEEEEEEECC | 28576409 | ||
| 434 | Phosphorylation | QSRLITITTTLFPKG HHEEEEEEEEECCCC | 21454597 | ||
| 435 | Phosphorylation | SRLITITTTLFPKGS HEEEEEEEEECCCCC | 28576409 | ||
| 436 | Phosphorylation | RLITITTTLFPKGSR EEEEEEEEECCCCCC | 28576409 | ||
| 489 | Phosphorylation | GKPAKAFSLNPERMN CCCCHHHCCCHHHHC | - | ||
| 895 | Phosphorylation | MPLVDPNSPVNAKKT CCCCCCCCCCCCCCC | 20415495 | ||
| 932 | Phosphorylation | VAKPSIMSPGHLRAS CCCCCCCCCCCCCCC | - | ||
| 939 | Phosphorylation | SPGHLRASTPEIMAT CCCCCCCCCCCCEEE | 24759943 | ||
| 940 | Phosphorylation | PGHLRASTPEIMATT CCCCCCCCCCCEEEC | 29899451 | ||
| 947 | Phosphorylation | TPEIMATTPDGTVSY CCCCEEECCCCCEEC | 29899451 | ||
| 951 | Phosphorylation | MATTPDGTVSYDNKA EEECCCCCEECCCCC | 29899451 | ||
| 1118 | Phosphorylation | RFLFPQQSLRHHLFI HCCCCHHHHHHHHHH | 22705319 | ||
| 1156 | Phosphorylation | HQITRYQYCALKAMS CCCCHHHHHHHHHHH | 21454597 | ||
| 1274 | Phosphorylation | SDTNREIYEVSMQLM CCCCHHHHHHHHHHH | 26643407 | ||
| 1277 | Phosphorylation | NREIYEVSMQLMQIL CHHHHHHHHHHHHHH | 26643407 | ||
| 1379 | Phosphorylation | SRLLLPGSSPSSPED CCEECCCCCCCCCCH | 23737553 | ||
| 1380 | Phosphorylation | RLLLPGSSPSSPEDE CEECCCCCCCCCCHH | 23737553 | ||
| 1382 | Phosphorylation | LLPGSSPSSPEDEVK ECCCCCCCCCCHHHC | 23737553 | ||
| 1383 | Phosphorylation | LPGSSPSSPEDEVKD CCCCCCCCCCHHHCC | 25521595 | ||
| 1396 | Phosphorylation | KDREGEVTASHGLKG CCCCCCEEECCCCCC | 29899451 | ||
| 1538 | Phosphorylation | GTTSSSNTVVAGQDS CCCCCCCEEECCCCC | 28576409 | ||
| 1576 | Phosphorylation | HTRLESRYSNSSGGS HHHHHHCCCCCCCCC | 29899451 | ||
| 1577 | Phosphorylation | TRLESRYSNSSGGSY HHHHHCCCCCCCCCC | 27841257 | ||
| 1580 | Phosphorylation | ESRYSNSSGGSYDED HHCCCCCCCCCCCCC | 29899451 | ||
| 1583 | Phosphorylation | YSNSSGGSYDEDKND CCCCCCCCCCCCCCC | 25521595 | ||
| 1593 | Phosphorylation | EDKNDPISPYTGWLL CCCCCCCCCCCHHHH | - | ||
| 1728 | Phosphorylation | TLTMQPAYQPEYLYT EEECCCCCCCHHEEC | - | ||
| 1821 | Ubiquitination | TPKNQNSKSAEQLSN CCCCCCCCCHHHHHH | 22790023 | ||
| 1878 | Ubiquitination | FQIFRALKQPLSAHA HHHHHHHCCCCCHHH | 22790023 | ||
| 1933 | Phosphorylation | LKNSDLFTVLSRSSS HHCCCHHHHHCCCCC | 27742792 | ||
| 1936 | Phosphorylation | SDLFTVLSRSSSPDL CCHHHHHCCCCCCCC | 25521595 | ||
| 1938 | Phosphorylation | LFTVLSRSSSPDLSS HHHHHCCCCCCCCCC | 29899451 | ||
| 1939 | Phosphorylation | FTVLSRSSSPDLSSS HHHHCCCCCCCCCCC | 25521595 | ||
| 1940 | Phosphorylation | TVLSRSSSPDLSSSS HHHCCCCCCCCCCCC | 25521595 | ||
| 1944 | Phosphorylation | RSSSPDLSSSSKLTA CCCCCCCCCCCCCCC | 27742792 | ||
| 1945 | Phosphorylation | SSSPDLSSSSKLTAS CCCCCCCCCCCCCCC | 26643407 | ||
| 1946 | Phosphorylation | SSPDLSSSSKLTASR CCCCCCCCCCCCCCC | 26643407 | ||
| 1947 | Phosphorylation | SPDLSSSSKLTASRK CCCCCCCCCCCCCCC | 26643407 | ||
| 1955 | Phosphorylation | KLTASRKSTGQLNVN CCCCCCCCCCCCCCC | 23737553 | ||
| 1956 | Phosphorylation | LTASRKSTGQLNVNP CCCCCCCCCCCCCCC | 25521595 | ||
| 1968 | Phosphorylation | VNPGTPGSGGGGGGS CCCCCCCCCCCCCCC | - | ||
| 1989 | Phosphorylation | ERSRHQRSFSVPKKF CCCCHHCCCCCCCCC | 29472430 | ||
| 1991 | Phosphorylation | SRHQRSFSVPKKFGV CCHHCCCCCCCCCCC | 29472430 | ||
| 2003 | Phosphorylation | FGVVDRSSDPPRSAT CCCCCCCCCCCCCCC | 21454597 | ||
| 2010 | Phosphorylation | SDPPRSATLDRIQAC CCCCCCCCHHHHHHH | 25521595 | ||
| 2023 | Phosphorylation | ACTQQGLSSKTRSNS HHHHCCCCCCCCCCC | 29899451 | ||
| 2219 | Phosphorylation | WVNVVCRYLHEAYAD HHHHHHHHHHHHHHH | 26745281 | ||
| 2224 | Phosphorylation | CRYLHEAYADITLNM HHHHHHHHHHCHHHH | 26745281 | ||
| 2228 | Phosphorylation | HEAYADITLNMVTYL HHHHHHCHHHHHHHH | 26745281 | ||
| 2233 | Phosphorylation | DITLNMVTYLAELLE HCHHHHHHHHHHHHH | 26745281 | ||
| 2234 | Phosphorylation | ITLNMVTYLAELLEK CHHHHHHHHHHHHHC | 26745281 | ||
| 2302 | Phosphorylation | LKLVVSRSASLVLPS HHHHHHCCCCCCCCC | 29899451 | ||
| 2304 | Phosphorylation | LVVSRSASLVLPSYQ HHHHCCCCCCCCCCC | 29899451 | ||
| 2309 | Phosphorylation | SASLVLPSYQHSDLS CCCCCCCCCCCCCCC | 29899451 | ||
| 2358 | Phosphorylation | RYDELQNSSGRDGKP CHHHHHCCCCCCCCC | 27841257 | ||
| 2375 | Phosphorylation | MAVTRSASSTSSGSN EEEEECCCCCCCCCC | 29899451 | ||
| 2377 | Phosphorylation | VTRSASSTSSGSNSN EEECCCCCCCCCCCC | 29899451 | ||
| 2378 | Phosphorylation | TRSASSTSSGSNSNV EECCCCCCCCCCCCE | 25521595 | ||
| 2379 | Phosphorylation | RSASSTSSGSNSNVL ECCCCCCCCCCCCEE | 21183079 | ||
| 2381 | Phosphorylation | ASSTSSGSNSNVLVP CCCCCCCCCCCEEEE | 29899451 | ||
| 2383 | Phosphorylation | STSSGSNSNVLVPVS CCCCCCCCCEEEECC | 22807455 | ||
| 2410 | Phosphorylation | EKLVHVLSLCGQEVG HHHHHHHHHHCCHHC | 21183079 | ||
| 2419 | Phosphorylation | CGQEVGLSKNPSVIF HCCHHCCCCCCCEEE | 22324799 | ||
| 2427 | Phosphorylation | KNPSVIFSSCGDLDL CCCCEEECCCCCCCC | 21183079 | ||
| 2428 | Phosphorylation | NPSVIFSSCGDLDLP CCCEEECCCCCCCCC | 21183079 | ||
| 2457 | Phosphorylation | EQENMDDTNSEQQFR CCCCCCCCCHHHHHH | 27742792 | ||
| 2459 | Phosphorylation | ENMDDTNSEQQFRVF CCCCCCCHHHHHHHE | 25521595 | ||
| 2495 | Phosphorylation | NWGVRRRSLDSLDKC CHHHHHCCHHHHCCC | 27742792 | ||
| 2498 | Phosphorylation | VRRRSLDSLDKCDMQ HHHCCHHHHCCCCHH | 22324799 | ||
| 2516 | Phosphorylation | ERQLSRSTPSLNKMS HHHHHCCCCCHHHCC | 22753416 | ||
| 2518 | Phosphorylation | QLSRSTPSLNKMSHE HHHCCCCCHHHCCCC | 29899451 | ||
| 2653 | Phosphorylation | NRGLDQYTLASFGEG CCCCCHHHHCCCCCC | 20415495 | ||
| 2656 | Phosphorylation | LDQYTLASFGEGDRG CCHHHHCCCCCCCCC | 28066266 | ||
| 2665 | Phosphorylation | GEGDRGVSPPPSPFF CCCCCCCCCCCCHHH | 20415495 | ||
| 2669 | Phosphorylation | RGVSPPPSPFFSAIL CCCCCCCCHHHHHHH | 20415495 | ||
| 2673 | Phosphorylation | PPPSPFFSAILAAFQ CCCCHHHHHHHHHHC | 20415495 | ||
| 2810 | Phosphorylation | WLANCKATFAGGSRD HHHHCCCEECCCCCC | 20415495 | ||
| 2815 | Phosphorylation | KATFAGGSRDGVITC CCEECCCCCCCEEEE | 22753416 | ||
| 2983 | S-palmitoylation | NHSLTEICTKLMELN CCHHHHHHHHHHHHC | 28680068 | ||
| 3014 | Phosphorylation | TAFLPDSSVSGTSL- EEECCCCCCCCCCC- | 29899451 | ||
| 3016 | Phosphorylation | FLPDSSVSGTSL--- ECCCCCCCCCCC--- | 25293948 | ||
| 3018 | Phosphorylation | PDSSVSGTSL----- CCCCCCCCCC----- | 25293948 | ||
| 3019 | Phosphorylation | DSSVSGTSL------ CCCCCCCCC------ | 20415495 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 2516 | T | Phosphorylation | Kinase | CDK1 | P11440 | Uniprot |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FRY_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FRY_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of FRY_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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