PTPR2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTPR2_MOUSE
• UniProt AC: P80560
• Protein Name: Receptor-type tyrosine-protein phosphatase N2
• Gene Name: Ptprn2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1001
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type I membrane protein . Predominantly found on dense-core secretory granules. So
• Protein Description: Plays a role in vesicle-mediated secretory processes. [PubMed: 21732083 Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation]
• Protein Sequence: MGPPLPLLLLLLLPPPLPRALPAPASARGRQLPGRLGCLFEDGLCGSLETCVNDGVFGRCQKVPVMDTYRYEVPPGALLHLKVTLQKLSRTGFTWQDDYTQRVIAQELANLPKAYLWHGEASGPARSLQQNADNEKWFSLEREVALAKTLRRYLPYLELLSQTPTANAHSRIDHETRPAKGEDSSPENILTYVAHTSALTYPPATRAKYPDNLLRPFSRLQPDELSPKVDGDIDKQKLIAALGAYTAQRLPGENDPEPRYLVHGSARAPRPFSATALSQRWPPPPGDAKDSPSMDDDTLLQSLLKDLQQNSEVDRLGPLKEEKADSVAGAIQSDPAEGSQESHGRGAEGQPREQTDAPETMLQDHRLSEVDDPVYKEVNRLSFQLGDLLKDYGSPLLPEGPLLEKSSREEIKKSEQPEEVLSSEEETAGVEHVRSRTYSKDLFERKPNSEPQPRRLEDQFQNRAPELWEDEESLKLAAQGPPSGGLQLEVQPSEEQQGYILTGNNPLSPEKGKQLMDQVAHILRVPSSFFADIKVLGPAVTFKVSANIQNMTTADVIKAAADNKDQLEKATGLTILQSGIRPKGKLKLLPHQEEQEDSTKFILLTFLSIACILGVLLASSLAYCLRHNSHYKLKDKLSGLGADPSADATEAYQELCRQRMAIRPQDRSEGPHTSRINSVSSQFSDGPMPSPSARSSTSSWSEEPVQSNMDISTGHMILAYMEDHLKNKNRLEKEWEALCAYQAEPNSSLVAQREENAPKNRSLAVLTYDHSRILLKSQNSHGSSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCAVIVMLTPLSENGVRQCHHYWPDEGSNLYHVYEVNLVSEHIWCQDFLVRSFYLKNLQTNETRTVTQFHFLSWYDQGVPSSTRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILKALPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
139	Phosphorylation	ADNEKWFSLEREVAL CCCCCCHHHHHHHHH	28.36	22324799
184	Phosphorylation	RPAKGEDSSPENILT CCCCCCCCCHHHHHH	43.41	29899451
185	Phosphorylation	PAKGEDSSPENILTY CCCCCCCCHHHHHHH	48.86	22817900
259	Methylation	GENDPEPRYLVHGSA CCCCCCCCEEEECCC	35.44	24129315
302	Phosphorylation	DDDTLLQSLLKDLQQ CHHHHHHHHHHHHHH	35.32	23140645
326	Phosphorylation	LKEEKADSVAGAIQS CCHHHHHHHCHHCCC	20.80	30372032
333	Phosphorylation	SVAGAIQSDPAEGSQ HHCHHCCCCCCCCCC	39.17	22817900
339	Phosphorylation	QSDPAEGSQESHGRG CCCCCCCCCCCCCCC	23.45	25521595
342	Phosphorylation	PAEGSQESHGRGAEG CCCCCCCCCCCCCCC	24.49	24925903
406	Phosphorylation	EGPLLEKSSREEIKK CCCCCCCCCHHHHHC	25.83	29899451
414	Phosphorylation	SREEIKKSEQPEEVL CHHHHHCCCCCHHHH	36.14	25521595
422	Phosphorylation	EQPEEVLSSEEETAG CCCHHHHCCHHHHHC	40.66	25521595
423	Phosphorylation	QPEEVLSSEEETAGV CCHHHHCCHHHHHCC	44.88	25521595
427	Phosphorylation	VLSSEEETAGVEHVR HHCCHHHHHCCHHHH	31.80	22324799
438	Phosphorylation	EHVRSRTYSKDLFER HHHHHCCCCHHHHHC	16.77	28059163
439	Phosphorylation	HVRSRTYSKDLFERK HHHHCCCCHHHHHCC	21.05	28059163
449	Phosphorylation	LFERKPNSEPQPRRL HHHCCCCCCCCCCHH	60.21	28059163
550	N-linked_Glycosylation	KVSANIQNMTTADVI EEECCCCCCCHHHHH	26.43	-
605	Phosphorylation	STKFILLTFLSIACI HHHHHHHHHHHHHHH	21.05	25521595
620	Phosphorylation	LGVLLASSLAYCLRH HHHHHHHHHHHHHHC	16.06	25521595
636	Ubiquitination	SHYKLKDKLSGLGAD CCCCHHHHHCCCCCC	42.86	-
638	Phosphorylation	YKLKDKLSGLGADPS CCHHHHHCCCCCCCC	37.40	29899451
673	Phosphorylation	DRSEGPHTSRINSVS CCCCCCCCHHCCCCC	23.88	27841257
674	Phosphorylation	RSEGPHTSRINSVSS CCCCCCCHHCCCCCC	28.29	27841257
678	Phosphorylation	PHTSRINSVSSQFSD CCCHHCCCCCCCCCC	22.47	21082442
680	Phosphorylation	TSRINSVSSQFSDGP CHHCCCCCCCCCCCC	20.45	22817900
681	Phosphorylation	SRINSVSSQFSDGPM HHCCCCCCCCCCCCC	32.84	21183079
684	Phosphorylation	NSVSSQFSDGPMPSP CCCCCCCCCCCCCCC	33.74	25521595
690	Phosphorylation	FSDGPMPSPSARSST CCCCCCCCCCCCCCC	25.82	25521595
692	Phosphorylation	DGPMPSPSARSSTSS CCCCCCCCCCCCCCC	40.42	21183079
697	Phosphorylation	SPSARSSTSSWSEEP CCCCCCCCCCCCCCC	28.20	-
713	Phosphorylation	QSNMDISTGHMILAY CCCCCCCCCHHHHHH	31.29	28576409
733	Ubiquitination	KNKNRLEKEWEALCA HCCCHHHHHHHHHHH	73.12	-
762	Phosphorylation	ENAPKNRSLAVLTYD HCCCCCCCEEEEEEC	30.03	-
941	Phosphorylation	GAGRSGTYVLIDMVL CCCCCCCHHHHHHHH	9.22	-
956	Acetylation	NKMAKGAKEIDIAAT HHHHCCCCCCCHHHH	64.96	-
963	Phosphorylation	KEIDIAATLEHLRDQ CCCCHHHHHHHHHHC	24.53	28285833

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTPR2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTPR2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTPR2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PTPR2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-678, AND MASSSPECTROMETRY.
PubMed: 17114649