DZIP3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DZIP3_MOUSE
• UniProt AC: Q7TPV2
• Protein Name: E3 ubiquitin-protein ligase DZIP3
• Gene Name: Dzip3
• Organism: Mus musculus (Mouse).
• Sequence Length: 1204
• Subcellular Localization: Cytoplasm .
• Protein Description: E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA..
• Protein Sequence: MDSLAEEFFVSGNPDVEEQTKEETEIIAEKPVTQLDKQKMDISADPEPVNALLEIKKVLNPISALPKGVFPNIEKFIQEDFSFQTMQREVTTHSQTGEEIVPALTLHFLITQLEMALRNIQASNYTAQQINVGYYLTLLFLYGVALTERAKKEDCIEAENKFLVMKMVIQESEICENFMCLVYFGRGLLRCAQKRYNGALLEFYKSLQEIGDTDDNWFEVDPTDDEDLPTTFKDSLNNFIKTTESNIMKETICSYLDCERSCEADILKNTNYKGFFQLMCSKSCCIYFHKICWKKFKNLKYPGESDQSFSGQKCLKEGCPGDMVRMLQCDVPGIVKILFEVVRKDEYITIENLGASYKNLMSLELTDTDIRPKFNLKPNTKDEVPIFKLDYNYFYHLLHIIIISGTDMVRQIFDEAMPPTLLKKELLIHKNVLEPYYNHLWTNHPLGGSWHLLYPPNKELPQSKQFDLCLLLALIKHLNVFPAPRKGWDMEPPSSDLSKSADILRLCKYRDILLSEILMNGLTELQFNSIWKKVSDILLRLGMKQDDLDKVKENPIENISLDYHQLSIYLGIPVPEIIQRMLSCYQQGITLQSITGSQRLDVEEFQNDEEDLSPPVMEYNIDVKSNTEIQLAEINKDVASIPSESSTESVKDLQEVKSKTKKKKRTKSNKKDKDSEDEQVSYMVEKDDQLETEQVDVNTLSTYMKTDTSDAQEDSAAEDKFCSLDELHILDMVEQGSSGKESTDFKETEKERLAHQHQLYKLQYECEDYKRQLKTVTFRWQENQMLIKKKEKIIVSLNQQVAFGINKMSKLQRQIHAKDDEIKNLKDQLSLKRSQWEMEKHNLESTVKTYLNKLNAETSRALTAEVYFLQCRRDFGLLHLEQTEKECLNQLARVTHMAASNLESLQLKAAVDSWNAIVADVRNKIAFLRTQYNEQINKVKQGFALSTLPPVQLPPPPPSPEILIQQFLGRPLVKESFFRPILTVPQMPAVCPGVISAAVQPRPPLMPGITWAMPTPIGDTVSPSASLCSEPLMINWERITDRLKTAFPQQTRKELTDFLQQLKDSHGKSVSRLTFDEIVYKISQMIEPKKSESEEKSAQDGNNASPSHTASQPNAPQDPKSAQGSATWEGDKDMDNEEEEEEPCVICHENLSPENLSVLPCAHKFHSQCIRPWLMQQGTCPTCRLHVLQPEEFPGHPNGQLPKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
347	Phosphorylation	EVVRKDEYITIENLG HHHCCCCCEEEEECC	17.31	-
613	Phosphorylation	QNDEEDLSPPVMEYN CCCCCCCCCCCEEEE	39.21	22817900
619	Phosphorylation	LSPPVMEYNIDVKSN CCCCCEEEEEECCCC	10.18	30635358
640	Phosphorylation	EINKDVASIPSESST EECCCHHHCCCCCCC	34.58	26643407
643	Phosphorylation	KDVASIPSESSTESV CCHHHCCCCCCCCHH	48.73	25521595
645	Phosphorylation	VASIPSESSTESVKD HHHCCCCCCCCHHHH	47.07	21149613
646	Phosphorylation	ASIPSESSTESVKDL HHCCCCCCCCHHHHH	31.94	25521595
647	Phosphorylation	SIPSESSTESVKDLQ HCCCCCCCCHHHHHH	41.37	26643407
649	Phosphorylation	PSESSTESVKDLQEV CCCCCCCHHHHHHHH	34.26	21149613
675	Phosphorylation	SNKKDKDSEDEQVSY CCCCCCCCHHHHHHH	53.33	25521595
681	Phosphorylation	DSEDEQVSYMVEKDD CCHHHHHHHEEECCC	13.75	23140645
715	Phosphorylation	TSDAQEDSAAEDKFC CCCHHCCCHHHHCCC	28.73	23684622
796	Phosphorylation	KKEKIIVSLNQQVAF CCCEEEEECHHHHHH	15.93	20139300
809	Phosphorylation	AFGINKMSKLQRQIH HHCHHHHHHHHHHHH	31.65	20139300
858	Phosphorylation	LNKLNAETSRALTAE HHHHCHHHHHHHHHE	22.54	24759943
1097	Phosphorylation	KSESEEKSAQDGNNA CCCCHHHHCCCCCCC	34.15	20415495
1105	Phosphorylation	AQDGNNASPSHTASQ CCCCCCCCCCCCCCC	29.11	23684622
1107	Phosphorylation	DGNNASPSHTASQPN CCCCCCCCCCCCCCC	30.86	25521595
1109	Phosphorylation	NNASPSHTASQPNAP CCCCCCCCCCCCCCC	32.13	20415495
1111	Phosphorylation	ASPSHTASQPNAPQD CCCCCCCCCCCCCCC	47.53	23684622

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DZIP3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DZIP3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DZIP3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDAC1_MOUSE	Hdac1	physical	18206970

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.