UBS3B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBS3B_MOUSE
• UniProt AC: Q8BGG7
• Protein Name: Ubiquitin-associated and SH3 domain-containing protein B
• Gene Name: Ubash3b
• Organism: Mus musculus (Mouse).
• Sequence Length: 638
• Subcellular Localization: Cytoplasm. Nucleus .
• Protein Description: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination..
• Protein Sequence: MAAREELYSKVTPRRDRLQRPGTVKHGSALDVLLSMGFPRARAQKALASTGGRSVQAACDWLFSHVGDPFLDDPLPREYVLYLRPTGPLAQKLSDFWQQSKQICGKNKAHNIFPHITLCQFFMCEDSKVDALGEALQTTVSRWKCKFSAPLPLELYTSSNFIGLFVKEDSAEVLKKFAADFAAEAASKTEVHVEPHKKQLHVTLAYHFQASHLPTLEKLAQNIDVKLGCDWVATIFSRDIRFANHETLQVIYPYSPQNDDELELVPGDFIFMSPMEQTSTSEGWIYGTSLTTGCSGLLPENYITKADECSTWIFHGSYSILNTVSSSSLAFGDGALERRQYEDQGLGETTPLTIICQPMQPLRVNSQPGPQKRCLFVCRHGERMDVVFGKYWLSQCFDAKGRYIRTNLNMPHSLPQRSGGFRDYEKDAPITVFGCMQARLVGEALLESNTVIDHVYCSPSLRCVQTAHNILKGLQQDNHLKIRVEPGLFEWTKWVAGSTLPAWIPPSELAAANLSVDTTYRPHIPVSKLAISESYDTYINRSFQVTKEIISECKSKGNNILIVAHASSLEACTCQLQGLSPQNSKDFVQMVRKIPYLGFCSCEELGETGIWQLTDPPILPLTHGPTGGFNWRETLLQE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAAREELYSKVTPRR CCHHHHHHHHCCCCC	15.10	25266776
9	Phosphorylation	AAREELYSKVTPRRD CHHHHHHHHCCCCCH	33.02	25266776
10	Ubiquitination	AREELYSKVTPRRDR HHHHHHHHCCCCCHH	36.25	-
12	Phosphorylation	EELYSKVTPRRDRLQ HHHHHHCCCCCHHCC	18.14	22345495
23	Phosphorylation	DRLQRPGTVKHGSAL HHCCCCCCCCCCCHH	29.12	29176673
341	Phosphorylation	GALERRQYEDQGLGE CHHHHCCCCCCCCCC	21.47	25367039
350	Phosphorylation	DQGLGETTPLTIICQ CCCCCCCCCEEEEEE	16.40	26745281
353	Phosphorylation	LGETTPLTIICQPMQ CCCCCCEEEEEEECC	14.97	26745281
366	Phosphorylation	MQPLRVNSQPGPQKR CCCCCCCCCCCCCCE	34.59	26745281
400	Ubiquitination	LSQCFDAKGRYIRTN HHHHHCCCCCEEEEC	45.85	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBS3B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBS3B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBS3B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JAK2_MOUSE	Jak2	physical	12370296

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.