JKIP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: JKIP1_MOUSE
• UniProt AC: Q8BVL9
• Protein Name: Janus kinase and microtubule-interacting protein 1
• Gene Name: Jakmip1
• Organism: Mus musculus (Mouse).
• Sequence Length: 626
• Subcellular Localization: Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Colocalizes with the microtubule network. Localizes to the cell body and neurites of hippocampal neurons where it accumulates in granules. Localizes to the tail and to a lower extent to
• Protein Description: Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements..
• Protein Sequence: MSKKGRSKGDKPEAETDSVQMANEELRAKLTNIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREALIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLADAREEARRTFDGERQRLQQEILELKAARKQAEEALSNCMQADKAKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKERVILALEKELGVQTGQTQRLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMAELMGGQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEELLHSIQRMEEKLKSLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDETTTREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDAAWVEEKQVLMRTNQDLLEKIYRLEMEENQLKSEMQDAKDQNELLEFRVLELEVRDSICCKLSNGADILFEPKLKFM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
370	Acetylation	ENVEMKEKLSAQASL HCHHHHHHHHHHHHH	42.07	6568717
378	Acetylation	LSAQASLKRHTSLND HHHHHHHHHCCCCHH	39.37	6569227
381	Phosphorylation	QASLKRHTSLNDLSL HHHHHHCCCCHHHCC	38.65	28833060
382	Phosphorylation	ASLKRHTSLNDLSLT HHHHHCCCCHHHCCC	21.03	21082442
387	Phosphorylation	HTSLNDLSLTRDEQE CCCCHHHCCCCCHHH	30.47	28833060
389	Phosphorylation	SLNDLSLTRDEQEIE CCHHHCCCCCHHHHH	32.47	28833060
464	Phosphorylation	TSYNTDRTDRTPATP CCCCCCCCCCCCCCC	32.42	25293948
467	Phosphorylation	NTDRTDRTPATPEED CCCCCCCCCCCCHHH	21.78	25293948
470	Phosphorylation	RTDRTPATPEEDLDE CCCCCCCCCHHHCCC	32.22	24704852
478	Phosphorylation	PEEDLDETTTREEAD CHHHCCCCCCHHHHH	32.89	25521595
479	Phosphorylation	EEDLDETTTREEADL HHHCCCCCCHHHHHH	23.08	21183079
480	Phosphorylation	EDLDETTTREEADLR HHCCCCCCHHHHHHH	43.43	21183079

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of JKIP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of JKIP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of JKIP1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KIF1B_MOUSE	Kif1b	physical	17532644
GABR1_MOUSE	Gabbr1	physical	17532644
GABR2_MOUSE	Gabbr2	physical	17532644

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.