KIF1B_MOUSE - dbPTM
KIF1B_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KIF1B_MOUSE
UniProt AC Q60575
Protein Name Kinesin-like protein KIF1B
Gene Name Kif1b
Organism Mus musculus (Mouse).
Sequence Length 1816
Subcellular Localization Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Mitochondrion. Colocalizes with synaptophysin at synaptic cytoplasmic transport vesicles in the neurites of hippocampal neurons..
Protein Description Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility..
Protein Sequence MSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKQDPETNLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDIDPLIDDYSGSGGKYLKDFQNNKHRYLLASENQRPGNFSTASMGSLTSSPSSCSLNSQVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCLFRSERSNTGEVIVTLEPCERSETYVNGKRVAHPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDYESKLQALQRQVETRSLAAETTEEEEEEEEVPWTQHEFELAQWAFRKWKSHQFTSLRDLLWGNAVYLKEANAISVELKKKVQFQFVLLTDTLYSPVPPELLPSEMEKTHEDRPFPRTVVAVEVQDLKNGATHYWSLDKLKQRLDLMREMYDRAGEVASSAQDDSETTMTGSDPFYDRFHWFKLVGSSPIFHGCVNERLADRTPSPTFSTADSDITELADEQQDAMEDFDDEAFVDDTGSDAGTEEGSELFSDGHDPFYDRSPWFILVGRAFVYLSNLLYPVPLIHRVAIVSEKGEVRGFLRVAVQAIAADEEAPDYGSGIRQSGTAKISFDNEYFNQSDFSSAAMTRSGLSLEELRIVEGQGQSSEVISPPEEVNRMNDLDLKSGTLLDGKMVMEGFSEEIGNHLKLGSAFTFRVTVLQASGILPEYADIFCQFNFLHRHDEAFSTEPLKNNGRGSPLGFYHVQNIAVEVTESFVDYIKTKPIVFEVFGHYQQHPLHLQGQDLNSPPQPSRRFFPPPMPLSKPVPATKLNTMNKTTLGQSMSKYDLLVWFEISELEPTGEYIPAVVDHTAGLPCQGTFLLHQGIQRRITVTIIHEKGSELHWKDVRELVVGRIRNKPEVDEAAVDAVLSLNIISAKSLKAAHSSSRTFYRFEAVWDSSLHNSLLLNRVTPYGEKIYMTLSAYLELDHCIQPAVITKDVCMVFYSRDAKISPPRSLRNLFGSGYSKSPDSNRVTGIYELSLCKMADTGSPGMQRRRRKVLDTSVAYVRGEENLAGWRPRGDSLILEHQWELEKLELLHEVEKTRHFLLLRERLGDSVPKSLSDSLSPSLSSGTLSTSTSISSQISTTTFESAITPSESSGYDSADVESLVDREKELATKCLQLLTHTFNREFSQVHGSISDCKLSDISPIGRDPSVSSFSSSTLTPSSTCPSLVDSRSSSMDQKTPEANSRASSPCQEFEQFQIVPTVETPYLARAGKNEFLNLVPDIEEVRAGSVVSKKGYLHFKEPLSSNWAKHFVVVRRPYVFIYNSDKDPVERGIINLSTAQVEYSEDQQAMVKTPNTFAVCTKHRGVLLQALNDKDMNDWLYAFNPLLAGTIRSKLSRRCPSQPKY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSGASVKVA
------CCCCCEEEE		55.13-
106PhosphorylationTGAGKSYTMMGKQEE
CCCCCCEECCCCHHH		14.0528576409
161UbiquitinationVRDLLNPKNKGNLRV
HHHHHCCCCCCCCCC		70.94-
201UbiquitinationDLMDAGNKARTVAAT
HHHHCCHHHHEEEEE		38.02-
204PhosphorylationDAGNKARTVAATNMN
HCCHHHHEEEEECCC		21.2519854140
208PhosphorylationKARTVAATNMNETSS
HHHEEEEECCCCCCC		25.8419854140
214PhosphorylationATNMNETSSRSHAVF
EECCCCCCCCCCEEE		19.9919854140
294UbiquitinationEVDNCTSKSKKKKKT
HHCCCCCCCCCCCCC		48.41-
325PhosphorylationNLGGNSRTAMVAALS
CCCCCCCHHHEEECC		20.9422942356
367UbiquitinationINEDPNAKLVRELKE
CCCCCCHHHHHHHHH		54.90-
377PhosphorylationRELKEEVTRLKDLLR
HHHHHHHHHHHHHHH		33.30-
407UbiquitinationDYSGSGGKYLKDFQN
CCCCCCCCCCHHHCC		51.43-
410UbiquitinationGSGGKYLKDFQNNKH
CCCCCCCHHHCCCCE		54.10-
466PhosphorylationSIQERIMSTPGGEEA
HHHHHHHCCCCHHHH		29.1320469934
467PhosphorylationIQERIMSTPGGEEAI
HHHHHHCCCCHHHHH		14.4720469934
494UbiquitinationLNETWEEKLRKTEAI
HHHHHHHHHHHHHHH		41.92-
522PhosphorylationAIREDGGTLGVFSPK
EEEECCCEEEEECCC		26.3528066266
527PhosphorylationGGTLGVFSPKKTPHL
CCEEEEECCCCCCCC		33.1422817900
647PhosphorylationARAEREKTPSAETPS
HHHHHHCCCCCCCCC		20.0919060867
649PhosphorylationAEREKTPSAETPSEP
HHHHCCCCCCCCCCC		43.9221183079
652PhosphorylationEKTPSAETPSEPVDW
HCCCCCCCCCCCCCC		31.6519060867
654PhosphorylationTPSAETPSEPVDWTF
CCCCCCCCCCCCCHH		63.0519060867
663 (in isoform 3)Phosphorylation-34.8825521595
665 (in isoform 3)Phosphorylation-45.7025521595
669 (in isoform 3)Phosphorylation-54.5221743459
690AcetylationQEMEILYKKEKEEAD
HHHHHHHHHHHHHHH		51.5219858553
709PhosphorylationQQRLDYESKLQALQR
HHHCCHHHHHHHHHH		32.2229109428
722PhosphorylationQRQVETRSLAAETTE
HHHHHHHHHCCCCCC		29.7626643407
727PhosphorylationTRSLAAETTEEEEEE
HHHHCCCCCCCHHHH		34.4826745281
728PhosphorylationRSLAAETTEEEEEEE
HHHCCCCCCCHHHHC		32.6726745281
1024PhosphorylationEEAPDYGSGIRQSGT
CCCCCCCCCCCCCCE		25.4725338131
1024 (in isoform 3)Phosphorylation-25.4729550500
1033UbiquitinationIRQSGTAKISFDNEY
CCCCCEEEEEECCCC		38.43-
1048 (in isoform 3)Phosphorylation-21.7526643407
1050 (in isoform 3)Phosphorylation-11.2225521595
1054PhosphorylationSSAAMTRSGLSLEEL
CHHHHHCCCCCHHHE		34.6124925903
1057PhosphorylationAMTRSGLSLEELRIV
HHHCCCCCHHHEEEE		36.9418388127
1064 (in isoform 3)Phosphorylation-5.6726643407
1066 (in isoform 3)Phosphorylation-26.4826643407
1067 (in isoform 3)Phosphorylation-32.9926643407
1069 (in isoform 3)Phosphorylation-35.5826643407
1071PhosphorylationVEGQGQSSEVISPPE
EECCCCCCCCCCCHH		28.1728066266
1072 (in isoform 3)Phosphorylation-49.4726643407
1074 (in isoform 3)Phosphorylation-4.4926643407
1075PhosphorylationGQSSEVISPPEEVNR
CCCCCCCCCHHHHCC		39.3125521595
1089UbiquitinationRMNDLDLKSGTLLDG
CCCCCCCCCCCCCCC		46.64-
1122 (in isoform 3)Phosphorylation-15.96-
1129 (in isoform 3)Phosphorylation-5.5526643407
1138 (in isoform 3)Phosphorylation-4.6325521595
1211PhosphorylationLQGQDLNSPPQPSRR
CCCCCCCCCCCCCCC		45.3029899451
1363PhosphorylationRFEAVWDSSLHNSLL
EEEEEECCCCCCHHH		21.06-
1364PhosphorylationFEAVWDSSLHNSLLL
EEEEECCCCCCHHHH		31.04-
1416PhosphorylationYSRDAKISPPRSLRN
ECCCCCCCCCHHHHH		28.3026824392
1420PhosphorylationAKISPPRSLRNLFGS
CCCCCCHHHHHHHCC		37.1422817900
1427PhosphorylationSLRNLFGSGYSKSPD
HHHHHHCCCCCCCCC		27.50-
1429PhosphorylationRNLFGSGYSKSPDSN
HHHHCCCCCCCCCCC		18.02-
1452PhosphorylationSLCKMADTGSPGMQR
EEHHHCCCCCCHHHH		29.9825521595
1454PhosphorylationCKMADTGSPGMQRRR
HHHCCCCCCHHHHHH		22.0025521595
1467PhosphorylationRRRKVLDTSVAYVRG
HHHHHHCCEEHHHCC		22.4228066266
1468PhosphorylationRRKVLDTSVAYVRGE
HHHHHCCEEHHHCCC		12.3828066266
1487PhosphorylationGWRPRGDSLILEHQW
CCCCCCCEEEEEEEH		21.8225521595
1559PhosphorylationTTFESAITPSESSGY
CEECCCCCCCCCCCC		22.0722807455
1573PhosphorylationYDSADVESLVDREKE
CCCCCHHHHHHHHHH		33.28-
1584UbiquitinationREKELATKCLQLLTH
HHHHHHHHHHHHHHH		27.60-
1598PhosphorylationHTFNREFSQVHGSIS
HHHCHHHHHHCCCHH		26.9223984901
1603PhosphorylationEFSQVHGSISDCKLS
HHHHHCCCHHCCCHH		12.2123684622
1605PhosphorylationSQVHGSISDCKLSDI
HHHCCCHHCCCHHHC		38.3626824392
1610PhosphorylationSISDCKLSDISPIGR
CHHCCCHHHCCCCCC		20.5623984901
1613PhosphorylationDCKLSDISPIGRDPS
CCCHHHCCCCCCCCC		18.5626824392
1620PhosphorylationSPIGRDPSVSSFSSS
CCCCCCCCCCCCCCC		38.6323984901
1622PhosphorylationIGRDPSVSSFSSSTL
CCCCCCCCCCCCCCC		29.9723984901
1623PhosphorylationGRDPSVSSFSSSTLT
CCCCCCCCCCCCCCC		27.3023984901
1625PhosphorylationDPSVSSFSSSTLTPS
CCCCCCCCCCCCCCC		25.9023984901
1626PhosphorylationPSVSSFSSSTLTPSS
CCCCCCCCCCCCCCC		25.9023984901
1627PhosphorylationSVSSFSSSTLTPSST
CCCCCCCCCCCCCCC		26.6623984901
1628PhosphorylationVSSFSSSTLTPSSTC
CCCCCCCCCCCCCCC		36.2823984901
1630PhosphorylationSFSSSTLTPSSTCPS
CCCCCCCCCCCCCCH		22.6323984901
1632PhosphorylationSSSTLTPSSTCPSLV
CCCCCCCCCCCCHHH		32.8023984901
1633PhosphorylationSSTLTPSSTCPSLVD
CCCCCCCCCCCHHHC		34.9223984901
1634PhosphorylationSTLTPSSTCPSLVDS
CCCCCCCCCCHHHCC		32.5423984901
1637PhosphorylationTPSSTCPSLVDSRSS
CCCCCCCHHHCCCCC		43.0823984901
1643PhosphorylationPSLVDSRSSSMDQKT
CHHHCCCCCCCCCCC		30.62-
1644PhosphorylationSLVDSRSSSMDQKTP
HHHCCCCCCCCCCCH		28.68-
1645PhosphorylationLVDSRSSSMDQKTPE
HHCCCCCCCCCCCHH		27.8530635358
1650PhosphorylationSSSMDQKTPEANSRA
CCCCCCCCHHHHHCC		22.2626643407
1655PhosphorylationQKTPEANSRASSPCQ
CCCHHHHHCCCCCCH		35.9529899451
1658PhosphorylationPEANSRASSPCQEFE
HHHHHCCCCCCHHHH		33.4327818261
1659PhosphorylationEANSRASSPCQEFEQ
HHHHCCCCCCHHHHC		28.8027087446
1672PhosphorylationEQFQIVPTVETPYLA
HCCCEECCCCCCCHH		21.7823984901
1675PhosphorylationQIVPTVETPYLARAG
CEECCCCCCCHHCCC		16.9423984901
1677PhosphorylationVPTVETPYLARAGKN
ECCCCCCCHHCCCCC		22.0323984901
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KIF1B_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KIF1B_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KIF1B_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CLK1_HUMANCLK1physical
26496610
FANCG_HUMANFANCGphysical
26496610
NCOA4_HUMANNCOA4physical
26496610
DYSF_HUMANDYSFphysical
26496610
RAD50_HUMANRAD50physical
26496610
NAV1_HUMANNAV1physical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KIF1B_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1487, AND MASSSPECTROMETRY.
"Specific phosphopeptide enrichment with immobilized titanium ionaffinity chromatography adsorbent for phosphoproteome analysis.";
Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.;
J. Proteome Res. 7:3957-3967(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1454, AND MASSSPECTROMETRY.

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