KLHL7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLHL7_MOUSE
• UniProt AC: Q8BUL5
• Protein Name: Kelch-like protein 7
• Gene Name: Klhl7
• Organism: Mus musculus (Mouse).
• Sequence Length: 586
• Subcellular Localization: Nucleus . Cytoplasm . Colocalizes with CUL3 in punctate structures at the perinuclear region of the cytoplasm.
• Protein Description: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination (By similarity)..
• Protein Sequence: MATSGVEKSSKKKTEKKLAAREEAKLLAGFMGVMNNMRKQRTLCDVILTVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLSQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREELAGGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLSSCEVYDPATETWTELCSMIEPRKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWRGVTVKCAAVGSVIYVLAGFQGVGRLGHILEYNTETDKWIANSKVRAFPVTSCLICVVDTCGANEETLET

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	EKSSKKKTEKKLAAR CCCCCHHHHHHHHHH	63.01	-
82	Phosphorylation	TNMLESKSFEVELKD CCCCCCCCEEEEECC	35.60	21743459
191	Phosphorylation	QLDVKRVTHLLSQDT HCCHHHHHHHHCCCE	15.73	24719451
200	Phosphorylation	LLSQDTLTVRAEDQV HHCCCEEEEEEHHHH	15.27	24719451
208	Phosphorylation	VRAEDQVYDAAVRWL EEEHHHHHHHHHHHH	8.33	24719451
239	Phosphorylation	KVRFPLISKNFLSKT HCCCCCCCCCCCCCC	29.27	25338131
244	Phosphorylation	LISKNFLSKTVQAEP CCCCCCCCCCCCCCC	23.34	25338131
293	Phosphorylation	PRRKKHDYRIALFGG CCCCCCCEEEEEECC	12.02	22871156
301	Phosphorylation	RIALFGGSQPQSCRY EEEEECCCCCCCCCC	38.78	22871156

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLHL7_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLHL7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLHL7_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KLHL7_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.