| UniProt ID | RGS6_MOUSE | |
|---|---|---|
| UniProt AC | Q9Z2H2 | |
| Protein Name | Regulator of G-protein signaling 6 | |
| Gene Name | Rgs6 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 472 | |
| Subcellular Localization |
Cytoplasm . Cytoplasm, cytosol . Membrane Peripheral membrane protein . Nucleus . Cell membrane . Interaction with GNB5 mediates translocation to the nucleus. |
|
| Protein Description | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity.. | |
| Protein Sequence | MAQGSGDQRAVGIADPEESSPNMIVYCKIEDIITKMQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTDETQSQSPVHIPSQPIRKTTKDDIRKQITFLNAQIDRHCLKMSKVAESLIAYTEQYVEYDPFITPAEPSNPWISDDITLWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLSVQDLKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDLLLAKKKGKSLAGKRLTGLMQSS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 50 | Ubiquitination | GVPIRTVKSFLSKIP CCCHHHHHHHHHCCC | 34.57 | - | |
| 51 | Phosphorylation | VPIRTVKSFLSKIPS CCHHHHHHHHHCCCC | 27.38 | 21454597 | |
| 54 | Phosphorylation | RTVKSFLSKIPSVVT HHHHHHHHCCCCCCC | 26.91 | 21454597 | |
| 232 | Phosphorylation | NPQKVKKSVYGVTDE CHHHHHHHHHCCCCC | 18.17 | 24925903 | |
| 234 | Phosphorylation | QKVKKSVYGVTDETQ HHHHHHHHCCCCCCC | 16.99 | 24925903 | |
| 237 | Phosphorylation | KKSVYGVTDETQSQS HHHHHCCCCCCCCCC | 24.61 | 24925903 | |
| 240 | Phosphorylation | VYGVTDETQSQSPVH HHCCCCCCCCCCCCC | 36.01 | 24925903 | |
| 242 | Phosphorylation | GVTDETQSQSPVHIP CCCCCCCCCCCCCCC | 39.79 | 25521595 | |
| 244 | Phosphorylation | TDETQSQSPVHIPSQ CCCCCCCCCCCCCCC | 33.85 | 25521595 | |
| 250 | Phosphorylation | QSPVHIPSQPIRKTT CCCCCCCCCCCCCCC | 48.24 | 24925903 | |
| 336 | O-linked_Glycosylation | RVKRWGFSFDEILKD HHHHHCCCHHHHHHH | 28.05 | 30059200 | |
| 336 | Phosphorylation | RVKRWGFSFDEILKD HHHHHCCCHHHHHHH | 28.05 | 29899451 | |
| 368 | Phosphorylation | ENLRFWLSVQDLKKQ CCHHHEEEHHHHHCC | 14.34 | 19060867 | |
| 466 | Phosphorylation | SLAGKRLTGLMQSS- CCCHHHHHHHHHCC- | 32.10 | 22324799 | |
| 471 | Phosphorylation | RLTGLMQSS------ HHHHHHHCC------ | 24.85 | 22324799 | |
| 472 | Phosphorylation | LTGLMQSS------- HHHHHHCC------- | 27.61 | 22324799 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RGS6_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RGS6_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RGS6_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of RGS6_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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