EXOG_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EXOG_MOUSE
• UniProt AC: Q8C163
• Protein Name: Nuclease EXOG, mitochondrial
• Gene Name: Exog
• Organism: Mus musculus (Mouse).
• Sequence Length: 368
• Subcellular Localization: Mitochondrion inner membrane.
• Protein Description: Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity..
• Protein Sequence: MAAKSFASRLRDSRRFLNGFLAGAVVGAAGAGLTALQFFRRPDAESAKLARQPHESAEEAVLEQFGFPLAGTETRRYTNHALSYDQAKRVPRWVLEHISKDKIIGDADRKHCKFKPDPSVPSAFSALNEDYIGSGWSRGHMAPAGNNKFSSEAMAETFYLSNIVPQNFDNNSGYWNRIEMYCRELTERFEDVWIVSGPLTLPHTRNDGTKTVSYQVIGEDNVAVPSHLYKVILARRSPESTEPLALGAFVVPNKAIGFQSQLSEFQVSLHDLEKMSGLVFFPRLDRSRDIRNICSVDTCKLLGFQEFTLYLSTRKIDGARSVARLEKVLEALKSSGVEPDDYFLSRYEKKLEELKAKEQKDAQLEKQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
288	Methylation	FPRLDRSRDIRNICS ECCCCCCCCHHHHCC	44.24	-
295	Phosphorylation	RDIRNICSVDTCKLL CCHHHHCCHHHHHHC	21.16	29899451
315	Acetylation	TLYLSTRKIDGARSV EEEEEECCCCCHHHH	45.28	8277187
327	Malonylation	RSVARLEKVLEALKS HHHHHHHHHHHHHHH	57.63	26320211
342	Phosphorylation	SGVEPDDYFLSRYEK CCCCCCHHHHHHHHH	17.50	17242355

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EXOG_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EXOG_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EXOG_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of EXOG_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.